Hypothermic Posted March 14, 2012 Share Posted March 14, 2012 Hello, I was given an Invega Sustenna injection for my paranoid schizophrenia, and have become concerned with the long-term effects such from decreased neuro-transmitter communications and decreased electrical activity after the injection. My mind is notably slower, and has troubles processing information, understanding speech, and forming new thoughts, something that was not a trouble before the injection. This is my first injection, and I'm suffering from catatonia, and other movement disorders such as rigid body movements, along with a lack of my synesthesia. If I were to experience visual or audio hallucinations, is it likely that if I were to stop this medications, that they would return as normal? "Additional pharmacological studies (primary, secondary, safety) were not submitted. Previously evaluated studies have indicated that paliperidone binds to 5-HT2A and dopamine D2 receptors, with the (+) and (-) enantiomers showing similar affinities." Personal Notes: I would experience colors, sounds, and other effects when presented with visual stimulus. I'm concerned about permanent receptor down-regulation and hard caused from this new anti-psychotic. Link to comment Share on other sites More sharing options...
tryp Posted March 14, 2012 Share Posted March 14, 2012 Please do not post your topic more than once. Link to comment Share on other sites More sharing options...
Guest Posted March 14, 2012 Share Posted March 14, 2012 The standard start dose is 234mg followed by 156mg a week later. So 22mg over isn't really that much in the scheme of things. Was it from a vial, or was it a prepackaged syringe? Edit: On second thought, are you sure you had a 256mg dose? 156mg does line up in terms of numbers better. It would be a low dose for a first dose though. Something I havn't figured out is if you were taking the medication before you got the injection? In tablet form? Link to comment Share on other sites More sharing options...
Hypothermic Posted March 14, 2012 Author Share Posted March 14, 2012 The standard start dose is 234mg followed by 156mg a week later. So 22mg over isn't really that much in the scheme of things. Was it from a vial, or was it a prepackaged syringe? Edit: On second thought, are you sure you had a 256mg dose? 156mg does line up in terms of numbers better. It would be a low dose for a first dose though. Something I havn't figured out is if you were taking the medication before you got the injection? In tablet form? No, I was given no previous injection. I was reading the pharmacodynamics of paliperidone and it indicated that it takes atound 49 days for the compound to be removed from the human body. I won't be taking another injection of this compound for it's series of negative effects on my person and cognition. Link to comment Share on other sites More sharing options...
Guest Posted March 14, 2012 Share Posted March 14, 2012 The main reason I asked is because it doesn't come in a vial. It comes in prepackaged syringes. Infact, to get a 256mg dose... you would have to use a fraction of a second syringe. Only 39 mg, 78 mg, 117 mg, 156 mg, and 234 mg doses are available. Dosing aside, Welcome to antipsychotics, Almost every drug has startup sedation, and a lot have it on a continued basis that doesn't wear off. As I said in chat earlier most of the sedation should wear off in a few days. Just wait it out. Link to comment Share on other sites More sharing options...
Hypothermic Posted March 14, 2012 Author Share Posted March 14, 2012 The main reason I asked is because it doesn't come in a vial. It comes in prepackaged syringes. Infact, to get a 256mg dose... you would have to use a fraction of a second syringe. Only 39 mg, 78 mg, 117 mg, 156 mg, and 234 mg doses are available. Dosing aside, Welcome to antipsychotics, Almost every drug has startup sedation, and a lot have it on a continued basis that doesn't wear off. As I said in chat earlier most of the sedation should wear off in a few days. Just wait it out. It came in a pre-packaged syringes. The does was 234mg of Invega Sustenna, and have become concerned with the effects of receptor down-regulation and damage from the interference of neurotransmitter communication in the varying pathways of the brain. I seeking to find out of the effects of Invega Sustenna have any permanent effect on the brain, as I've been unable to find proper information on the compound on the internet as it's now a new medication for the treatment or schizophrenia. Link to comment Share on other sites More sharing options...
Guest Posted March 15, 2012 Share Posted March 15, 2012 I seeking to find out of the effects of Invega Sustenna have any permanent effect on the brain, as I've been unable to find proper information on the compound on the internet as it's now a new medication for the treatment or schizophrenia. Look up risperidone, Invega is the main active metabolite of it, And thus has similar effects. Generally theres nothing perminant though, You will have to look at quack sites for a someone to say there is, because no one else has a definitive answer. Link to comment Share on other sites More sharing options...
Guest Vapourware Posted March 15, 2012 Share Posted March 15, 2012 I have absolutely no idea what you are trying to ask anymore. Are you looking for justification to come off Invega? No-one can make you take a drug, unless you're on an involuntary treatment order. Link to comment Share on other sites More sharing options...
Hypothermic Posted March 15, 2012 Author Share Posted March 15, 2012 I have absolutely no idea what you are trying to ask anymore. Are you looking for justification to come off Invega? No-one can make you take a drug, unless you're on an involuntary treatment order. I'm asking of this medication can cause permanent receptor down-regulation and if the effects of this compound will ware off if I were to stop taking the medication. I had a question about my gift - colors, sounds, and waves were seen whenever I would experience a stimulus, and now that I've taken this injection, reality has been dulled quite drastically. Link to comment Share on other sites More sharing options...
dedoubt Posted March 15, 2012 Share Posted March 15, 2012 I don't know for sure, but I do not think the effects of an antipsychotic are permanent. I had a question about my gift - colors, sounds, and waves were seen whenever I would experience a stimulus, and now that I've taken this injection, reality has been dulled quite drastically. The way you viewed reality may have been seen as hallucinations by doctors, which is why you were given an antipsychotic. My antipsychotic takes away my hallucinations and delusions, which I am grateful for, because they were scary and bad. I might feel differently if my hallucinations were more like what you describe. Try to find something you can enjoy doing that will take your mind off of how different everything is. You will get used to the changes. Link to comment Share on other sites More sharing options...
Cetkat Posted March 17, 2012 Share Posted March 17, 2012 My answer would be no, the removal of the synesthesia is probably temporary. If you have true synesthesia, and your experiences are not a form of psychosis.. like you've had it since you were a kid and it's always been normal, then it should come back just fine as you're dealing with a physical state. If their lack was your only symptom, I'd wonder, but you're experiencing other issues like the cognitive dulling and movement problems - both of which would normally resolve. I'd bet you're looking at the same sort of process. The synesthesia connections are just as permanent as thought and movement. I'm not familiar with the injection. One thing you should know is that some resolutions of symptoms don't occur until a certain period of time after the active part of the medication abates. If the injection maintains effectiveness for those 49 days, you're looking at maybe 20-30 more before all is said and done - just as a personal estimate from AAP's in pill form. Just something to keep in mind so you don't worry prematurely if that's the case. Link to comment Share on other sites More sharing options...
Hypothermic Posted March 19, 2012 Author Share Posted March 19, 2012 Thank you for your comments. I've noted drastic decreases in memory and thinking performance after given this injection in terms of short and long term memory problems. I've even located articles on the sustained memory problems caused from the use of neuroleptics, as found here: http://lib.bioinfo.pl/paper:22311531. Link to comment Share on other sites More sharing options...
Guest Posted March 19, 2012 Share Posted March 19, 2012 Thank you for your comments. I've noted drastic decreases in memory and thinking performance after given this injection in terms of short and long term memory problems. I've even located articles on the sustained memory problems caused from the use of neuroleptics, as found here: http://lib.bioinfo.pl/paper:22311531. That paper is looking at a drug called Cerebrolysin. While the drug is given with an antipsychotic, It is not aimed at improving the side effects of the medication. OBJECTIVE: Cerebrolysin is a nootropic drug with unique neurotrophic activities directly affecting cerebral neurons. This study evaluated the efficacy and safety of cerebrolysin added to risperidone in patients with schizophrenia dominated by negative symptoms. The trial was actually aimed at the negative symptoms of schizophrena. Is that what you were after? Link to comment Share on other sites More sharing options...
Guest Vapourware Posted March 19, 2012 Share Posted March 19, 2012 Just a note... I have synaesthesia [i'm Australian and I'm sticking to UK spelling )- I perceive words and sounds in colours. I've taken a heap of antipsychotics - Abilify, Invega [topic of discussion here], ziprasidone, Solian, Seroquel, and Clozapine. None of them affected my synaesthesia in any way, although some of them gave me very obvious side effects like Parkinsonian symptoms. Medication can induce synasthesia in some people, but from what I've read, medication rarely impacts on synaesthesia. So I guess I wonder if what you are discussing is, in fact, synaesthesia or is more related to psychosis. I know that psychosis can cause changes in the perception of the senses. Link to comment Share on other sites More sharing options...
Cetkat Posted March 19, 2012 Share Posted March 19, 2012 I have synaesthesia [i'm Australian and I'm sticking to UK spelling ) Ah! I wondered why half my research for my project was using that form. Now I can switch back to typing "synaesthesia" without worrying that it's somehow wrong. None of them affected my synaesthesia in any way Good to know... it didn't strike me as something that would be common, whether that's what's going on here or not. Link to comment Share on other sites More sharing options...
WinterRosie Posted March 19, 2012 Share Posted March 19, 2012 My understanding of synaesthesia is that it is a physical difference in the brain. That we're all born that way and then as we go through toddlerhood a membrane forms in our brains dividing up the senses into being more strictly what most people experience (smell as smell, sounds as sounds, etc). However, in some people this membrane either doesn't form or is incomplete and so smell is touch, or sound is colour, etc. If synaesthesia has a physical root like this, how could an AP make it go away? I guess what I'm asking is, short of an MRI how could you know if your synaesthesia is psychosis-based? The answer being by how it's affected by an AP. In this case Invega. Link to comment Share on other sites More sharing options...
Hypothermic Posted March 25, 2012 Author Share Posted March 25, 2012 Do you have any comments about the long term of effects of Invega/Risperidone in terms of cognition, and if recovery is possible after the medication is stopped? Link to comment Share on other sites More sharing options...
Guest Posted March 25, 2012 Share Posted March 25, 2012 People have been on Risperidone for very long periods without any negative cognitive effects, After the drug is discontinued you should return to your previous state in time. Link to comment Share on other sites More sharing options...
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