tomtyger Posted October 25, 2005 Share Posted October 25, 2005 I've been taking Effexor XR for years and years with good results and no problems, although the really great effect started when i went to 300mg/day a few years ago. Been talking to the pdoc about continuing lack of motivation & pleasure/satisfaction/reward. Apparently it's at the higher doses that Effexor starts working on dopamine. He felt it'd be OK to increase the dose (to 375 then to 450) as long as my blood pressure was all right. The higher dose has helped a lot So, here's the thing: I've had high blood pressure problems since I was a teenager, and nothig would keep it down very well. But after my mother died 14 years ago, my blood pressure went down and stayed down. (Interesting connection, no?!) For mqny years now, with some diovanhct to help, it's been steady at 120-130/60-70. I started on the 450 mg/day in March of this year, and my blood pressure stayed just where it had been. No increase at all. I checked it often, and it never varied more than about +/- 10 mmHg. Then in August we went to England (where my son is studying) for a month. (The whole trip was glorious.) I didn't bring the blood-pressure-checking-thingy with, and when I got home I really didn't give the blood pressure a thought. But three weeks ago when I did check it, it was 170/98. WTF!! I've been checking it serveral times a day since, and here's the really weird thing: the bp is now wildly unsteady, 110/55 one day, 140/88 another. One day I took it first thing in the morning, and it was 153/89; two hours later it was 126/58. And, it's highest in the morning and goes down with exercise!! I'm not so awfully worried about the increase itself; significant, maybe, but not frighteningly high. If it were steady, I'd guess it's due to the increase in effexor, though it only showed up six months after the dose was upped to 450. It's the way it's changing all the time that Im having trouble understanding. Sometimes it stays fairly high long enough that I'm ready to call pdoc &/or primary guy and ask if they think it's the effexor that's doing this weird stuff. then it will settle down and mostly be at 120-140/65-90 range, and I forget about it. I hate calling md's about anything, and invoke all the procrastination skills I've honed over the years to avoid it. I do not want to cut back on the effexor. It's made enough difference that all sorts of people tell me how well I seem. Anyone have experiences anything like this? or know or have heard about such a thing? = = = = = finally, of course, it might not be the effexor at all. So here's the whole list: Effexor XR 450 mg/day Provigil 200 mg Strattera 120 mg Seroquel 100 mg at bedtime Trazodone 50 mg at bedtime Synthroid 0.015 mg Lamictal 200 mg Tramadol 100 mg 4-6 times/day plus Protonix, the Diovan, Flomax, Flonase, and Tylenol. Current dxs: MDD, BP!! (ultradian) PTSD, ADD, and a lot of sleep problems. Thanks, guys tom Link to comment Share on other sites More sharing options...
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