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Maybe if you ate it with a meal or not. If I eat it with a significantly sized meal, the drowsiness can come on suddenly and heavily within the hour. If I don't take it with a meal, it might not even make me drowsy. Taking it with milk I get kindasorta drowsy within two or three hours.

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I have the same issue! And I never eat when I take it. Some nights it hits in 40 minutes, and others it takes 3 hours. Very odd. I don't like it as I plan to be awake for two hours after I take it, and then some nights, after 40 minutes, I have to druggedly stumble to bed!

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Taking Seroquel with food gives it a small boost which seems to get it into your system quicker* thus making you feel sleepy quicker etc. I take mine at +/- 9pm and start to get sleepy about an hour later. It helps if towards the end of this hour I am in my jams and getting into bed, 9/10 times I will conk out there and then. If I try to stay up later than 10pm the intense sleepiness passes and I find it quite hard to get to sleep.

*Seroquel is marginally better absorbed with food. So if you feel you need a little boost in the dosage, try taking it with dinner or a late night snack.

Courtesy of Crazy Meds.

Claire

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I gave up trying not to take it w food as the label says... It just doesn't work w my schedule. We eat late and if I wait too long I am a zombie the next day. So more often than not I have food in my stomach.

Still, most of the time it hits fairly quickly and it took close to 3 hours last night. I wasn't happy because I had to get up somewhat early this am.

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I never take my Seroquel with food, as that is what it says on the box 'always take on an empty stomach or 1 hour before food'. I find the sedation usually kicks in for me after about 3 hours (that time has increased the longer I have been on the med), but there are times when it doesn't kick in until later (which is annoying as my insomnia is trouble falling asleep). I think the latest I have fallen asleep (taking Seroquel around 10:30pm) would be about 4am, but these days that is rare. I am no longer troubled by my insomnia.

On the other hand, if I take a painkiller (usually paracetamol) at the same time as my Seroquel, then the sedation kicks in pretty quickly (similar to how I was when I first went on Seroquel). That sucks as usually the times I need painkillers is in the evening. But because of this I have said no painkillers after 10pm.

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