RJG Posted October 26, 2005 Share Posted October 26, 2005 Hi! I would like to know all the medication WORLDWIDE that deal with dopamine reuptake, almost exclusively. Why am I asking for DRI? Because I have been taking Selegiline 15mg a day and I am actually fucking happy, and I don't mean euphoric or manic or just feeling "good", but I am actually fucking happy and it feels so wonderful. And fortunately there is almost no side effects whatsoever, except for the confusion. The confusion that I experience with Selegiline is enough to make me need to stop, its not that I want to, but I have to. I am a nursing student and I can not afford to be confused all the time, it just can't be like this. I have talked with my psychopharmacologist about this, and he says that the confusion is not a good sign, but if it makes me happy then he could prescribe something to counter the side effects. Prescribing meds to counteract the others is not something I want to do unless absolutly neccessary. Why am I asking specifically for DRI? Because I took Cymbalta and it made me feel "good", but never happy. I was never quite happy on Cymbalta, plus it damaged my liver a lot and now I have to deal with that. So yeah, please tell me all the licensed DRI world wide. Or anything that works on dopamine almost exclusively. I have looked into Rasagiline, but its really expensive and I dont want to pay for it if I dont have to. Oh yeah, and the reason I ask for worldwide is because my psychopharmacologist is willing and has in the past, prescribed me and ordered non-US licensed meds. And one more thing, I can't take Wellbutrin because of my past history of being Bulimic. Link to comment Share on other sites More sharing options...
WholeNewHomeBody Posted October 26, 2005 Share Posted October 26, 2005 Okay, I don't know all the names, but for the most part the only S(elective)DRIs you are going to find are anti-parkinsons/anti-Alzheimers drugs. Why? To put it quite simply, because they get you high. I think Namenda is a new one in the states, plus memantine (generic) and I am fairly sure ketamine is a DRI, but you don't need to go there. Levadopa/ carbidopa (generics) are APark and AAlz drugs that sound like they might just have what you're looking for, I don't know why. Link to comment Share on other sites More sharing options...
RJG Posted October 26, 2005 Author Share Posted October 26, 2005 Thank You. Anafagodma I didn't know that DRI make you high, although I know there is a connection between dopamine and euphoria. But like I said I am not euphoric, nor do I feel "good", I feel happy. Its an amazing feeling that I haven't felt in years. I mean its an over all happiness, I have my good days and my bad days but I wake up every morning knowing that I am going to get threw it alright. I smile now, and I go out and have fun, and I actually have fun. I am actually motivated to go out and help people. I am really hoping the EMSAM patch comes out soon. The thing thats different about the EMSAM patch is that it bypasses the liver, and from what my pyshcopharmacoligist says it most likely the problems with the liver that cause the confusion. Hey told me a lot about how people with uncontrolled hepatitis or people with alcoholism can suffer confusion and memory loss, and while its not confirmed as the cause of my confusion he thinks it might be the cause. Link to comment Share on other sites More sharing options...
Velvet Elvis Posted October 27, 2005 Share Posted October 27, 2005 I assume you are interested in agonists as well. All the CNS stims except for provigil are thought to work on the reuptake of DA and NA. Jerod talks about some meds you might be interested in here. Another one that I have had personal experience with is amantidine. It's an old anti-viral with lots of off label uses. It made my anxiety and OCD worse. Some of the newer anti-parkensons meds such as requip are dopamine reuptake inhibitors but are useless for mood as they are too selective and have no effect on mood. The trend with these drugs right now is to make sure they don't have much of an abuse potential as it's harder to market controlled substances. Unfortunately, the ones that get you high at big doses are the same ones that help with mood at lower doses. Link to comment Share on other sites More sharing options...
RJG Posted October 27, 2005 Author Share Posted October 27, 2005 Thank you Velvet Elvis I guess I'm going to talk to my doctor about either Rasagiline or Moclobemide (spelling?) Link to comment Share on other sites More sharing options...
Whacked Posted October 29, 2005 Share Posted October 29, 2005 Not sure if this is quite what you're looking for, but here is a list of medications that may increase dopamine: deprenyl / Wellbutrin (bupropion) / Uprima (apomorphine) / Mirapex (pramipexole) / Permax (pergolide) / Dostinex (cabergoline) / Requip (ropinirole) Taken from this web page: http://qualitycounts.com/fpdopamine.htm Link to comment Share on other sites More sharing options...
peppermintpatty Posted February 15, 2006 Share Posted February 15, 2006 FYI--Namenda (memantine) is a glutamate inhibitor. I could be wrong, but I don't think it has anything to do with dopamine. ...but only on 2/14 (aka Black Tuesday) Link to comment Share on other sites More sharing options...
realitytest Posted May 18, 2006 Share Posted May 18, 2006 Whatsamatta with MAO inhibitors? NARDIL almost saved my life - and I have Treatment Resistent DEpression. Or it WOULD have saved my life it hadn't almost killed me anyhow. I got cardiac effects and extreme (as in unmeasurable) hypotension. But those were idiosyncratic and very rare, SOME hypotension is common but not to that degree (landed me in hospital for 10 days). But those are great meds. Ask Fiona - she feels the same about PARNATE. It was in an effort to get the great MAO effects (without many/most of the risks), that Bodkin came up with the Selegiline patch . He's the head researcher who spearheaded the whole idea. Maybe one of those two MAO's would work for you without the confusion. Who needs pastrami and cheddar cheese, right? Best, rt Link to comment Share on other sites More sharing options...
Libby Posted May 18, 2006 Share Posted May 18, 2006 I was never quite happy on Cymbalta, plus it damaged my liver a lot and now I have to deal with that.Carumba. I'm on 90mg of Cymbalta, so this scares me. How bad is your liver? Did you find out through bloodwork? What can do you about it? Hell, what can I do about my own liver? Maybe I should be buying milk thistle. Sorry for the threadjack, but I'm also wondering what Seroquel does to dopamine. Does it decrease it? Link to comment Share on other sites More sharing options...
realitytest Posted May 18, 2006 Share Posted May 18, 2006 Libby: Sorry for the threadjack, but I'm also wondering what Seroquel does to dopamine. Does it decrease it? Yep. Among the AAPs it's known as a "weak dopamine inhibitor" but they're all essentially based on the by now antique (so-called) dopamine hypothesis. That is, that sz (for which Seroquel was designed) is - if not caused by - at least symptomatically controlled, by blocking dopamine. The goal is to block only the dopamine receptors in a part of mid-brain called the striatum (and associated pathways), but it hits 'em all. This IMO is hell on the "consumer", as common sense would dictate. After all, dopamine is behind all "feel good" reactions, one way or the other. I'm convinced my son's depression is owing at least in part to this general dopamine blockade especially in the pre-frontal cortex. Not to mention cognitive dulling, and other negative sz symptoms. "They" are finally beginning to address the negative symptoms in med development, and there are a bunch at various stages of the pipeline. But not soon enough for me! This side effect of the meds, leads to a lot of confusion about what is secondary to the meds and what is "part of the disease process". Had a big fight recently with son's pdoc about just this (OK, a 30 second, "remember when you said, and I said...?" exchange). The only way to prove all that shit wasn't the illness progressing (funereal background music) was that they went away when he switched meds! OK, now I digressed frm your digression. This just happens to be one of my BIGGEST gripes about treatment for sz. So many side effects are unavoidable given "the present state of the Art" (necromancy). At least, let's avoid unneccessary ones by waving them all away as part of the disorder. And as you doubtless know, Lib, Seroquel is prescribed for everything but hangnails these days - off label. Still, yes, it DOES block dopamine - to a dose-dependent degree, of course. And some people are apparently scarcely if at all affected by the cognitive effects - like Chimpmaster (or else he's just so smart, he can't tell). Cheers, rt Link to comment Share on other sites More sharing options...
Libby Posted May 18, 2006 Share Posted May 18, 2006 Libby: Sorry for the threadjack, but I'm also wondering what Seroquel does to dopamine. Does it decrease it? Yep. Among the AAPs it's known as a "weak dopamine inhibitor" but they're all essentially based on the by now antique (so-called) dopamine hypothesis. That is, that sz (for which Seroquel was designed) is - if not caused by - at least symptomatically controlled, by blocking dopamine. The goal is to block only the dopamine receptors in a part of mid-brain called the striatum (and associated pathways), but it hits 'em all. This IMO is hell on the "consumer", as common sense would dictate. After all, dopamine is behind all "feel good" reactions, one way or the other. I'm convinced my son's depression is owing at least in part to this general dopamine blockade especially in the pre-frontal cortex. Not to mention cognitive dulling, and other negative sz symptoms. "They" are finally beginning to address the negative symptoms in med development, and there are a bunch at various stages of the pipeline. But not soon enough for me! This side effect of the meds, leads to a lot of confusion about what is secondary to the meds and what is "part of the disease process". Had a big fight recently with son's pdoc about just this (OK, a 30 second, "remember when you said, and I said...?" exchange). The only way to prove all that shit wasn't the illness progressing (funereal background music) was that they went away when he switched meds! OK, now I digressed frm your digression. This just happens to be one of my BIGGEST gripes about treatment for sz. So many side effects are unavoidable given "the present state of the Art" (necromancy). At least, let's avoid unneccessary ones by waving them all away as part of the disorder. And as you doubtless know, Lib, Seroquel is prescribed for everything but hangnails these days - off label. Still, yes, it DOES block dopamine - to a dose-dependent degree, of course. And some people are apparently scarcely if at all affected by the cognitive effects - like Chimpmaster (or else he's just so smart, he can't tell). Cheers, rt This is really interesting, RT, because I'm taking Seroquel for major depression and anxiety. Oddly enough, my thinking seems to be getting more clear. It's still cloudy, but I feel less removed from my surroundings, and I seem to be having better word recall, although I seem to be even worse than usual at remembering names. hmmm.... You know a lot about these things, so I hope you don't mind my asking: What's the difference between Seroquel and other AAP's? Do they all hit a smattering of dopamine receptors? Link to comment Share on other sites More sharing options...
realitytest Posted May 18, 2006 Share Posted May 18, 2006 This is really interesting, RT, because I'm taking Seroquel for major depression and anxiety. Oddly enough, my thinking seems to be getting more clear. It's still cloudy, but I feel less removed from my surroundings, and I seem to be having better word recall, although I seem to be even worse than usual at remembering names. hmmm.... You know a lot about these things, so I hope you don't mind my asking: What's the difference between Seroquel and other AAP's? Do they all hit a smattering of dopamine receptors? (Resisting temptation to run away screaming or announce I was called away on unexpected retreat). My but you HAVE asked a good question , Little Girl. (Did I hear the Twin Towers falling in the background). Next! The truth is that nobody really knows just how they work and how they differ, and even if they did, I am not up to reading all about the various hypotheses of mode of action included in every PI sheet. Neural pathways - heck, I can't even follow a road map! :embarassed: Some are supposed to hit some DA receptors more than others - they all have names, or rather numbers. Some (most new ones) also affect serotonin, most hit histamine receptors (one of BIG reasons they make for weight gain)...Abilify is even supposely able (I WONDER about this effect, myself) such that it decreases DA to a point and then acts as a mild reuptake inhibitor when it starts to be excessively depleted. Incidently, the first AP, thorazine was a new antihistamine, serendipitously discovered to work as an antipsychotic! So allergy mediation (and histamine) are intimately involved in how they work. Of course, they used to be called "major tranquilllizers" for a reason, and we all know Benadryl is sedating ("do not drive or operate heavy machinery when..."etc.). They keep finding out new chemicals involved in sz, so they're not stuck with the DA hypothesis forever with all its drawbacks, theoretically and in application. What they're working on most furiously now are glutamate mediation (an altogether different brain chemical) and nicotonic receptors (you know how so many people with sz take up smoking, apparently to - successfully - self-medicate?) . Also combination agonist-antagonists for different chemicals to try to counteract those accursed negative symptomsl Counter-intuitively, they seem to cause the most disability and social marginality. They are also the symptoms about which most with sz - and their families - complain the most bitterly. The pain of numbness. (And speaking as a mom who didn't see her son crack a smile for six months, I know why). There are other (possible) new APs so stage one in conception they're not even talked about . Anyhoo, if there's one slogan this site could adopt as it's LOGO and watchword, it's YMMV. Some meds work great for one set of folks, and are poison for others. Genetics, whether you have the enzymes to metabolize them, what transmitters YOU need (and where) - infinite etceteras It could well be for you, that your clarity of thinking was so messed up by deep anxiety that once that was controlled, you perked right up - and the old prefrontal cortex was entirely secondary. Also possible that it controlled your insomnia - and we all know how well we do crosswork puzzles without sleep, night after night after night. Seroquel IS a weak DA inhibitor besides, and I'll bet your dosage is low. These generalizations are just that and YMMV Hell, your mileage DID vary! My son was practically put into a state of hibernation by Abilify - most commonly abandoned for causing anxiety, excessive activation and insomnia! (And now I'll go make a mad dash for the uh..ladies room, yeah that's it!) rt XO Link to comment Share on other sites More sharing options...
Libby Posted May 19, 2006 Share Posted May 19, 2006 Thanks, RT. Yes, I am on a low dose of 50mg at the moment. I guess it could be as simple as quelling the deeprooted and paralyzing anxiety, however insomnia is kicking my ass lately. I went to sleep finally at 3:20 this morning. Overall, however, I'm functioning much better. Link to comment Share on other sites More sharing options...
realitytest Posted May 19, 2006 Share Posted May 19, 2006 Hi, Libby, I noticed after I posted what a super-dooper low dose Seroquel you're taking. If you're responding well to it and are still having trouble with insomnia, you might want to ask your pdoc to try you on a higher dose. It really knocks you out, so I hear, and in fact probably half the Seroquel scripts written these days are for insomnia. Taken at bedtime, of course. If you do a search here (or remedyfind), I'll bet you'll find a lot of feedback from people with intractable insomnia who've been helped by it. Like everything, it DOES have side effects though much less at lower doses. The main side effect is putting you to sleep! But different for all. Sometimes it's better to trust your doc - who knows your medical history - to decide if there's any reason not to try it (or not to up the dose). I find if I look up all possible side effects in advance, the power of suggestion can be so great, I can't always tell what's caused by the drug and what's expectation. (OTOH, I SURE wish someone had told me Nardil can cause orthostatic hypotension! ) rt Link to comment Share on other sites More sharing options...
Guest Orlando (Guest) Posted October 3, 2007 Share Posted October 3, 2007 Hi, the most specific DRI ist Amineptine. Seems it is off the market due to FDA banning it :-( It should be optimum medication vor ADHD because only dopamine uptake seems to be too high in ADHD people and if you give them MPH or Amphetamine you correct the dopamine uptake but mess up with the noradrenaline uptake... By the way, did you experience unwanted effects in the sexual area due to selegiline? Most dopaminerg drugs enhance libido and ability to reach orgasm, but i found controverse data about selegiline. Seems it can also decrease libido and cause anorgasmia... Best Regards Orlando Link to comment Share on other sites More sharing options...
null0trooper Posted October 4, 2007 Share Posted October 4, 2007 It should be optimum medication for ADHD because only dopamine uptake seems to be too high in ADHD people and if you give them MPH or Amphetamine you correct the dopamine uptake but mess up with the noradrenaline uptake... Noradrenaline is also involved, but there are already medications that work on NA levels in the frontal lobes without the US FDA and DEA taking up pitchforks and storming the labs. Link to comment Share on other sites More sharing options...
Guest Orlando (Guest) Posted October 5, 2007 Share Posted October 5, 2007 Yes, it seems NA is also involved, but from what I read, I only hear about prooves of too high dopamine reuptake transporter density, not NA reuptake transporters. Maybe the too fast reuptake of both catecholamines causes ADHD, so you may suffer from that if either one or both are reuptaken too fast. Then MPH and Amphetamine should help almost all of them (as long as there are not any additional deficiencies), while NA-reuptake-inhibitors should help good for the ones that have mostly too fast NA reuptake, fair for the ones with both DA and NA uptake and not much for the ones with dominant fast DA reuptake. On the other side, if you mostly suffer from a too high DA reuptake transporter density without having trouble with too fast NA reuptake, pure NA-reuptake-inhibitors will not help you very much, but mess up even more your situation because they would disturb your DA/NA balance even more. I had severe side effects with Reboxetine that I blame too hich NA availability for, like agitation, loss of libido, loss of errection and anorgasmia. For my ADHD symptoms it did not help more than a very little bit. We should not say one has ADHD and so he needs medication x, but we should look, what is the reason for his ADHD and then choose th emedications. As NA-reuptake-inhibition seems not to help me it seems I need DA-reuptake inhibiton which should be best done with Amineptine, which is not available anymore unfortunately. So I am gonna try MPH now, which I guess will help my ADHD symptoms because of the DA-reuptake-inhibition. Ok, it will also inhibit NA reuptake, but I hope as it leaves the DA/NA balance as it is in the first extent, it will not have those heavy side effects like NA-reuptake-inhibition alone. If MPH helps getting rid of my ADHD symptoms but has the same side effects as the Reboxetin, I wil know that what I need is Amineptin and will be stuck with having to find a source on the black market that I can afford :-( Regards orlando Link to comment Share on other sites More sharing options...
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