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anecdotes about parnate?


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yay, my parnate pal! maybe we can post our own anecdotes in case someone else is reading, too?

i've been on 10mg for five days. no mood increase. energy/alertness is increased though. and no more crying - it's like the thoughts are the same but they don't show on the outside anymore.

SE-wise, my appetite is shrinking and this freakin headache won't go away. pdoc says it will with time.

i see pdoc today for an increase, so i'll update if it makes a difference.

looking forward to hearing your experiences too, blue.

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i'm nervous as hell that i'm going to eat the wrong thing and give myself a stroke, heh. but that's my irrational fear talking. i'm not really hankering for anything i can't have yet. i already don't drink alcohol because of other meds, so that won't be so hard. i still wonder who eats banana peels? there must be enough people who do for them to include it on the "don't eat" list. but... really?

my husband has celiac and has to eat a special diet too and honestly, i'd rather mine than his. so that gives me better perspective, ie it could be worse than not eating deli meats anymore.

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i'm definitely going to miss me some cheese, too.

i found out who eats banana peels! pdoc says it's not uncommon in Germany. she laughed and said it's not as weird as you might think (she's rather well-traveled heh). so that's why it made the list of no-no's.

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thanks Kodos, those were really helpful and made me less fearful. i wanna be the man (in the first article) banging his fist on the desk demanding why nobody ever gave him parnate before!

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I met with the dietician and felt so overwhelmed that I burst into tears. I spoke to another staff member who said that dietician is way too over the top though (told me not to eat takeaway or eat out at all), so I'm sticking to it for now and seeing another one.

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Look for Fiona's old posts on this subject. She was a mod way back when CB first started. She did a lot of research on MAO-Is and diet and came to a lot of conclusions that kinda go against the grain.

Well, this is really the only MAOI food post I found of hers:

http://www.crazyboar...me/#entry164851

In all of my clicking around, I did however run across this on the, grantedly often inaccurate, wikipedia site:

A large dietary intake of tyramine (or a dietary intake of tyramine while taking MAO inhibitors) can cause the tyramine pressor response, which is defined as an increase in systolic blood pressure of 30 mmHg or more. The displacement of norepinephrine (noradrenaline) from neuronal storage vesicles by acute tyramine ingestion is thought to cause the vasoconstriction and increased heart rate and blood pressure of the pressor response. In severe cases, adrenergic crisis can occur.

However, if one has had repeated exposure to tyramine, there is a decreased pressor response; tyramine is degraded to octopamine, which is subsequently packaged in synaptic vesicles with norepinephrine (noradrenaline). Therefore, after repeated tyramine exposure, these vesicles contain an increased amount of octopamine and a relatively reduced amount of norepinephrine. When these vesicles are secreted upon tyramine ingestion, there is a decreased pressor response, as less norepinephrine is secreted into the synapse, and octopamine does not activate alpha or beta adrenergic receptors.

http://en.wikipedia.org/wiki/Tyramine

Could it actually be theoretically possible to acclimate yourself to the MAOI cheese effect? Or is that just full of shit?

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I'm fairly sure that is full of shit (not you, though. :) ). My dad cut way back on the number of foods that were forbidden with MAOIs for his patients. He kept close track of the research on tyramine (hell, he did some of the research) and MAOIs, and the list of foods now is MUCH shorter than it was in the 1970s. If he could have acclimated even a few of his patients, he would have, he was always willing to try new things if they were based on sound science.

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  • 2 weeks later...

The parnate had a side effect of making me incredibly agitated. I am normally SO quiet and sedate. I was pacing hallways and kicking skirting boards. I tore up bits of paper and took off and put on my hoodie four times in a row. I had fingernail marks all of my hands and I don't SI.

SO I spoke to Pdoc and we're adding some AAPS to try to counteract it, otherwise I'll have to discontinue and switch to another MAOI. I have a feeling i'll be asleep for the next few days so if you don't see me that's why.

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  • 3 weeks later...

If I take enough seroquel and time it properly (150mg XR at night, 50mg XR in the morning, 25 normal seroquel and another 75mg prn if I need it) the agitation is minimal but there's still a LOT more anxiety.

Tonight i wasn't home and took the seroquel two hours late and I'm going insane with agitation despite 50mg of normal seroquel as well.

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I have been on Parnate for about a year now and I have experienced no side effects, I guess I am one of the lucky ones.

I started out being really careful with what I ate, but then after a while I got lazy and started eating things I shouldn't and again had no ill effects. Now I pretty much eat anything I want, except for aged cheese and vegemite, I drink tap beer eat gourmet pizzas with pepperoni, eat avocado and sour cream, I even once had beef and blackbean from a takeawat joint not realising it was full of soy sauce, I have never felt any negative effects. But then again I have never gone overboard eating those things.

I am not recommending that anyone else do what I do (everyone is different), I think that the beta blockers that I am on might help too (for headaches) *shrugs*

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  • 4 weeks later...

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