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anyone switch to Luvox for less sexual S/Es? Help desperately needed!


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Hi All,

I was wondering if anyone here has made the switch from Lexapro (or any other SSRI) to Luvox to alleviate some/all sexual dysfunction caused by another. I am currently taking Lexapro for GAD/PD and it both does not control the anxiety as well as chemically castrates me. My doctor is in the process of doing a very slow cross-taper (I still have very little, if any, sexual functioning at this point) because anecdotally he states that there is less sexual dysfunction associated with Luvox due to an unknown or yet-to-be elucidated mechanism of action - perhaps action at the sigma-1 receptor site? He also stated that Luvox is great for anxiety disorders and most don't typically have to take the maximum 300mg/day dosage to get relief - even when the anxiety disorder/disorders are severe - which may explain why there are less people who suffer from intolerable sexual sides on Luvox. Both crazymeds and wikipedia state that Luvox is associated with less sexual dysfunction and this seems to be backed by anecdotes, although just as many anecdotes lay claim to pretty much every other SSRI with the exception of Paxil. I had been taking, prior to starting the cross-taper, 20mg of Lexapro without adequate relief and immense sexual dysfunction. Completely devastating as it obliterates my dating prospects at a time when people are starting to settle down (I'm 27).

Now, I know that SSRI usage is highly idiosyncratic in that what works for one may not work for another and one individual may suffer from intolerable sexual side effects on one SSRI while another may be sexually fine on the same medication. That said, has anyone found Luvox to be less harsh in this regard? How much were you taking? Any/all experiences/input welcome, including alternative medications that may be less harsh on sexual functioning.

I am desperate here! Help needed!!

Addendum: I should add that augmentation strategies are also welcomed. Memantine/Namenda and tiagabine/Gabitril are two that may be helpful for anxiety, allowing me to reduce the SSRI dose. Anyone think of any others?

Edited by basuraeuropea
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Before I was on Luvox I was on Prozac. If you look it up, Luvox is chemically similar to Prozac (and the chemical names are almost the same) so it's almost the same drug. They do this a lot, and find rearranging a few things will treat different symptoms. Pardon my lack of chemical terms.

On Prozac, 20mg, I was a basket case of anxiety and had no sex drive, couldn't orgasm. On Luvox I was much calmer (except at 300mg I went manic and it was dropped to 100mg) and my anxiety was less, combined with Xanax it was non-existant, I started actually having a sex drive and orgasms again. I really like Luvox.

The sexual side effects really do suck. I'm 27 and female. Hopefully it works out for you, good luck!

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Also, consider asking your doctor about adding Wellbutrin. It can help to alleviate SSRI-induced sexual dysfunction. It desn't help everyone, but it does for some people. Wellbutrin SR is generic if cost is a factor.

Edited by Cuttlefish
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Thanks - my doc has already tried that but I can't tolerate Wellbutrin even in ultra low doses as it exacerbates anxiety and throws me into a panicked state. A member mentioned upping the SSRI to counteract the stimulating effects of Wellbutrin but that leads to erectile dysfunction and my doctor has stated that Wellbutrin won't help in that regard, but rather only helps with desire and orgasm.

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