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Hi all! New member here. I've been having some serious trouble from what I can only assume is my Abilify, and am hoping I can find some similar experiences here.

I've been taking it (2mg) since April of this year. When I first started it, by the next morning, I was wide awake and fully energized between 6-7am. This continued until August no matter how much/little sleep I'd gotten the night before. I really enjoyed it and it also helped with my MDD (rx in signature).

Since August, I've been having difficulties keeping a normal sleep cycle. It started out with me not being able to get tired until later and later, and when I woke up it was nearly impossible to get out of bed; not because of my depression, but because of being so exhausted. In September, I found that I was able to go to sleep at a reasonable hour with the help of diphenhydramine, but even after getting 8 hours of rest, I still literally couldn't get out of bed sometimes. I basically felt like I'd just taken a 2 hour nap, which (for me) always make me feel more tired when I wake up than I did before the nap.

For the past 2-3 weeks, I haven't been able to get to sleep until 5-6am. I went to my psychiatrist last Tuesday and told her about all of this, but she didn't seem to think that the sleep problems and the Abilify were linked. She prescribed me Trazodone and thus far, it's been very hit or miss. I feel relaxed when I take it, but often not tired at all or enough to sleep. I've never had trouble like this before in my entire life, and the only thing I can think of is that it's the medication since it had the opposite effect in the beginning.

I have stopped taking the Abilify as of last week (on my own accord for the sleep troubles and for the fact that it costs $600) and am still wired all through the night even with the Trazodone. I'm wondering if it's because it may take up to a month to completely get out of my system (opinions?). Has anyone else experienced this trouble?

Thanks so much!

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I went to my psychiatrist last Tuesday and told her about all of this, but she didn't seem to think that the sleep problems and the Abilify were linked.

I took Abilify a few years ago and had a similar problem. My sleep cycle was all messed up. I was too awake and agitated, couldn´t sleep at night and was sleepy all day. I couldn´t keep my eyes opened. I even started getting auditory hallucinations after many days without sleeping. I didn´t like that med at all.

Meds can affect people differently.

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The point is, you took it for many months without severe sleep disruptions, making it unlikely to be the culprit. Not to mention, you are still having the same problem even after you stopped it. So Abilify does not correlate with your insomnia at all.

Please let your pdoc know that you stopped part of your cocktail immediately. You should have called your pdoc before making changes, some meds have serious withdrawal effects. Abilify had the worst withdrawal effects of any med I have taken, and I only took it a couple of months.

If you are adamantly opposed to the treatment this pdoc has prescribed you, either work with him to change it, or find another one. Being dishonest with your pdoc isn't going to help.

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Abilify has a really long half-life and therefore is much easier to discontinue than other meds that have a shorter half-life. From the PI, "The mean elimination half-lives are about 75 hours and 94 hours for aripiprazole and dehydro-aripiprazole, respectively." What this means is that Abilify (aripiprazole) has a half-life of about 75 hours and the active metabolite (dehydro-aripiprazole) has a half-life of 94 hours. So, yeah, if you've been taking it for months, it'll take a long time to get it out of your system. Not a month though.

I'm curious, if you thought it was Abilify that was making you unable to sleep, why didn't you just take it in the morning?

The few times I've tried Trazodone, I've found that the first few days were ok. Not great but not bad either. A few days into it and I start getting a hungover type of feeling. Like I could never completely wake up. I quit taking it because I like to be awake during the day.

I hope you figure out what the problem is but I'm with your pdoc, it is very unlikely that your problems are from Abilify.

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Thanks for all of your replies, all! I forgot to clarify that I always took it in the morning, along with all of my other meds (sans the Trazodone). I see my psych again next week, so I will let her know that I've quit taking the Abilify and am still having problems.

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