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differences between ssris, snris and dnris


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My shrink said that one isn't necessarily better than the other, snris are supposed to be stronger and are more for physical depression, but that doesn't mean it will work better.

I am wondering if anyone here has found ssris to actually work better than snris or dnris.

I ask because Zoloft doesn't really pep me up but helps my ocd so I am pushing for wellbutrin too as I sleep a lot and don't have much motivation, should I be excited to start a dnri?

What have your experiences been between the types of RIs

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those ssri usually have some other working mechanisms, for example zoloft is also a weak dopamine reuptake inhibitor, so you get an additional mechanism with your antidepressant, especially at that 200mg dose.

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SSRIs make me manic. Wellbutrin (SNRI) has worked well for me for over 20 years, but we suspect it is pooping out. I believe we will try another SNRI before moving on to other classes.

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SSRIs have either done absolutely nothing or made me manic as hell. I'm currently on amitriptyline, which is a TCA, but is basically an SNRI with some other stuff thrown in unless I'm mistaken (which I could definitely be- correct me if I'm wrong). It's the only AD I've ever been on that has worked for me. And it works well.

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