Hi, all. I feel like a newb oldie: been on here a while, still feel dumb as shit with all the o chem breakdowns and acronyms.
Anyway- I've been maxed out on effexor xr for years now. I've taken it pretty consistently for...12 years? with a few breaks to try something new. There aren't many details I can remember well (always had a bad memory, now it's basically a vestigial feature), but here's what I've garnered:
*SSRIs and i seem to not mix. Not just some side effects, but all the side effects, and no or negative improvement.
*wellbutrin did nothing for me. Not good, not bad- just nothing.
*Effexor was good- great, even- before I tapped out. I've just been staying with it till I can figure something out.
*currently, I take 225 mg Effexor (and several doctors have told me now that they flat out won't go above that), 150 lamictal, and klonopin and Ambien as needed. (And as I've been mightily depressed lately...I've been "as needing" them a lot more.)
I've been wanting to change for a while now, and I've been studying up to see what might be some better options, but haven't had a tdoc or pdoc in the meantime. I'm meeting new ones shortly and I want to take some suggestions to them. Problem is that I'm allergic to a few things, with varying degrees of severity and type of allergic reactions. Any suggestions of SNRIs, TCAs, or MAOIs that aren't:
*sulfa-meds (full body hives. Like...full body- between my toes, in my buttcrack...😬)
*compazine (difficult breathing, light anaphylaxis.)
*darvocet, Vicodin (full-blown anaphylaxis.)
I have been given morphine with no reaction (so, what- does this mean that synethics cause issues, but cleaner natural versions don't?), and take imitrex regularly. I'm not smart enough to understand all of the individual components, and too ADD to have the patience to learn which causes what.
I feel like it's got be something pretty potent, since I've been middling- to severely-depressed pretty constantly (easily 8 out those 12 years), but I also don't need anything that's going to make me lethargic. Apathetic, fine- just please, no serious drowsiness.
I defer to you guys and gals and pals for what your thoughts are on what might be most effective, but also won't send me to the ER.
I welcome you to rate all the psychotropic drugs which you took in the past or are taking in the present. A short explanation of your experience with the drug(s) would be helpful, so that we better understand your rating.
Oh, and please tell us which conditions you treat(ed). Thanks.
Rating Scale is from 0 to 5... "zero" being the worst, "five" being the best.
Sertraline 2 / 5 - subtle effects. Did help with psychosomatic ailments, derealization and cognition, but caused SSRI-typical apathy & indifference. Not sure if it did anything for my social anxiety and psychomotor agitation. At most minor effects. I did take it for two years.
Mirtazapine 2 / 5 - elephant tranquilizer. Didn't like the severe sedation. Didn't sleep well on it, bad dreams. Caused RLS. Was good for appetite, weight gain and IBS. I was on it for two weeks.
Promethazine Syrup / Drops 20mg / ml | 3 / 5 - I rather liked that one. At a lowish dose (15 drops or so) it has a nice calming effect on me, without sedating me too much. Lowers anxiety and agitated states. Brings order into chaos. Good for appetite and stomach. I take it occasionally.
N-acetylcysteine (NAC) 2.5 / 5 - Is a good supplement. Heightened focus, less derealization, world seems more colorful. Interesting stuff. Definitely worth a try.
Conditions treated: Anxiety, depressive states, psychomotor agitation, somatization disorder.
Sertraline standalone makes many people somewhat apathetic, indifferent and unmotivated, and that's why doctor Gillman suggests augmenting it with Nortriptyline OR alternatively taking Clomipramine standalone for the full SNRI effect...
Did anyone here try both combos? I am getting back on antidepressants and not sure how to proceed... but if I had to choose, I would preferably go for one of the two possibilities.
I was prescribed Vraylar as a mood stabilizer for MDD, which I have been diagnosed with for 20 years, along with ADHD and social anxiety. Until I Vraylar gave me an acute manic episode for over a year, which I hid from my doctor because it was so much better than being depressed. But then I came clean and we realized I actually had hypomanic episodes about 2ce a year, but didn’t realize it, I just thought I had some energy. Anyway, I was wondering if anyone else has had this reaction to Vraylar?