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What has your experience been with Latuda and other AP's on your weight? Everything I've read about and been told says Latuda's supposedly weight neutral; however, I know that all AP's increase blood sugar, and this leads to weight gain.

 

I've been on 80mg of Latuda for a year now, and I've gained a little over 5 lbs, which is not a lot, but there's more to it, read on. Prior to starting the Latuda I had a brief stint on Risperdol, but it increased my Prolactin levels and made me stop getting my period, so I had to go off it. I didn't notice any changes in my weight on Risperdol. Before that I was on Clozaril for about 6 months and gained 30lbs. It was a last resort. I had tried everything else( including risperdol and latuda neither of which worked prior to the Clozaril) and had treatment resistant auditory hallucinations for 5 years.

 

I figured I would lose some of the weight from the Clozaril when I started the Latuda, since most of my weight gain was from medication.I am in recovery from anorexia ( starting when I began the Clozaril) and the only way I agreed to take Clozaril was if they gave me Metformin. They only gave me 500mg of Metformin, which isn't enough to really help with weight loss, but I didn't know that at the time. I wasn't as concerned about food or my body but hadn't increased my caloric intake that much and was still only eating once a day. I continued to exercise moderately and still do.

 

Given my small amount of food intake and exercise, I should have lost weight weight when I discontinued the Clozaril because that's what made me gain mostly and at a very rapid pace. Instead I have maintained all that weight and managed to gain even more weight on the Latuda. I don't think Latuda is as weight neutral as they claim. I know I would weigh less if I didn't take it or if I reduced my dose. I don't want to become anorexic again, but I don't want to gain anymore weight either. I discussed my concerns with doctor, and she prescribed me Metformin again after a 45 minute discussion. She's not pleased about the Metformin and was upset about my once a day eating regime. I had to agree to eat 3 small protein based meals a day, and she advised me to avoid sugar. She only prescribed the Metformin because she doesn't want me to reduce my Latuda or go off it because I'm doing so well.

 

Has anyone else experienced weight gain on Latuda? Even a small amount? How has it affected your weight?

 

I've always seemed to gain weight on the supposedly weight neutral AP's. I gained a ton of weight on Abilify (when I took it before I was psychotic, took it again after I was psychotic but cut my dose down to a tiny amount) and gained weight on Geodon. My doctor told me the other day that Abilify and Geodon aren't weight neutral. Anyone else gain weight on these? Which meds have caused weight gain?

 

I was anorexic and weighed 93lbs when I started the Clozaril. Normally I never would have taken a med that caused so much weight gain, but I was in an excellent hospital seeking help mainly for my depression. I wasn't looking for help with my eating disorder, and considering I had tried nearly every med possible with no relief, I didn't think they'd be able to make the voices go away.They were determined to treat all my syptoms at once- the psychosis, anorexia, and depression. Normally I avoided AP's that caused weight gain. Zyprexa was my worst nightmare, but I had tried it. I didn't really gain weight on it, but I wasn't on it long and it didn't work. I would try AP's, but if they caused the slightest bit of weight gain I either went off them or reduced the dose ( with or without my doctor's permission). I respected the doctors in this hospital and probably would not have been willing to try Clozaril anywhere else. They told me that I had to gain weight in order to get better and for some reason, I listened to them when I had ignored everyone else. the anorexia became really bad when I was 29 and got into recovery from substance abuse. I've been to inpatient treatment for ED's twice and had seen numerous specialists. Plus that's the field that I pursued for my academics and professional work, so I knew all about it.

 

I hated the Clozaril because of all the side effects, which is why I came off it. I prefer Latuda and am able to cope with it's side effects by taking other meds to counter act them. I'm glad the Latuda works to control my auditory hallucinations now, but I think that ECT and the Namenda play a big role in that too. As much as I'd love to come off an AP, I'm scared to mess with my current meds. I don't want the psychosis to come back. I doing so well now. But it's really hard to go from 93lbs to what I weigh now. I'm more than 35lbs heavier. I'm 5'4, so my BMI is still in the normal range, but I don't want to become overweight. I've weighed a little bit more before ( when I was 29 and on Abilify,before I got into recovery from substance abuse) and my horror at being so heavy triggered a massive slide into severe anorexia.

 

What do you do to cope with weight gain from meds? In your experience what is the med that caused the least and most weight gain? I know it varies from person to person. Anyone else prescribed Metformin to help with AP weight gain? Do you think the benefits of AP"s are greater than gaining some weight? Have you ever reduced your dose to lose weight? Would love to hear your stories.

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I lost a lot of weight on Latuda. Was on a low fat, low carbs, almost no sugar diet with lots of exercise. Basically, my version of the diabetic diet. I've gained some of it back, unfortunately, when I relaxed too much. (Many self-reprimands!)

 

Latuda does not stop me from loosing weight. However, I would guess that all AAPs require me to eat less and exercise more than if I was not on them. Or maybe it is just that my metabolism changed. That happens as we age. There's an increment that comes with each decade milestone. ;)

 

Seroquel and Depakote caused me to gain a lot of weight quickly. I ended up with type II diabetes after psych meds when I wasn't even close before them. That may be a factor in difficulty loosing weight. Not sure. Also not sure about other AAPs except for Risperdal, which I did not gain on, but I could not loose.

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I lost a lot of weight on Latuda. Was on a low fat, low carbs, almost no sugar diet with lots of exercise. Basically, my version of the diabetic diet. I've gained some of it back, unfortunately, when I relaxed too much. (Many self-reprimands!)

 

Latuda does not stop me from loosing weight. However, I would guess that all AAPs require me to eat less and exercise more than if I was not on them. Or maybe it is just that my metabolism changed. That happens as we age. There's an increment that comes with each decade milestone. ;)

 

Seroquel and Depakote caused me to gain a lot of weight quickly. I ended up with type II diabetes after psych meds when I wasn't even close before them. That may be a factor in difficulty loosing weight. Not sure. Also not sure about other AAPs except for Risperdal, which I did not gain on, but I could not loose.

That's great that you lost weight on Latuda. How much did you lose? What was your dose? Sorry to hear that you gained weight and became diabetic on Seroquel and Depakote. Is your diabetes under control now? Seroquel never made me gain weight oddly, but it never relieved my psychosis. I took it for a long time too. Depakote is one of those meds that made me gain a tiny bit of weight right away, and I flipped out, so I told my doctor we had to try something else. I think he was already prepared for that when he prescribed it but still wanted to try it.

 

I think eating like a diabetic is the best way to minimalize weight gain on AP's since they increase blood sugar. I used to eat like a diabetic when I was anorexic. I relaxed and allowed myself to consume carbs again once I was in recovery from anorexia because I didn't want to be so restrictive and worry about food. I still ate a fairly low calorie diet, so i didn't think it would make that much of a difference, but I think you really have to be careful with sugar when you're on an AP. After getting weighed at the GP's last week and freaking out, and having a long talk with with Pdoc, I have decided to go with a high protein diet. I'm eating  a small all protein breakfast and lunch and then a small dinner. I'm not going to cut out all carbs, but will try to eat mostly vegetables and protein at dinner. I'll still allow myself to eat some complex carbs at dinner, but no more yogurt, bread, pasta, or orange juice except on special occassions. And I get to have a slice of pizza once a week.I can't go back to excessive restricting because I could easily get out of control again, and I don't want that. Eating 3 times a day is scary, but my meals are small and it means I eat a smaller dinner, which is helpful. Hopefully with the dietary changes and Metformin, I'll be able to drop about 5-8 lbs or so ( not looking to loose more than that, don't want to slide back into anorexic mode) and avoid future weight gain.

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Abilify has not been weight neutral for me. I've gained 30 lbs on Abilify.

 

I really wish doctors and nurses would counsel patients on the side effects of APs. Just sit down and take 5 or so extra minutes to explain that APs might affect your appetite, you may gain weight and how to avoid that weight gain. Discuss topics like eating healthy on an AP and the importance of exercise. Talk about the cravings APs might give you. Stuff like that. 

 

I'm seeing my doctor this week to talk about adding metformin to help me lose weight. We are also reducing my dose, hopefully down to 10 mg, down from 30 mg. We are trying to find the best dose that controls my symptoms, with the least amount of side effects. I also experience intense sedation on Abilify, sleeping an average of 12 hours a night. Which obviously is not going to help me lose weight!

 

I found that the dose reduction from 30 mg to 20 mg really curbed my appetite. Abilify gives me intense sugar cravings, but reducing the dose really helped with that. I have hopes that reducing the dose further and adding metformin will really control my appetite and weight gain. 

 

In the end, if reducing the dose and adding metformin doesn't stop me from gaining, then I'm going to talk to my doctor about changing anti-psychotics. Really, my goal is to just stop gaining. 

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I haven't gained weight on Latuda, but I'm very nervous about it, so I'm being a little more cautious with what I eat.  (Admittedly, my developing a gluten intolerance has helped with that.)  I usually gain weight on the weight-neutral meds too - my psychiatrist was shocked at how much I gained on the Geodon when I was on it years ago - I went from being 175ish to about 350.  NOT good, and will never take that stuff again.   It went away when I stopped it, so I think I'm allowed to be a little leery of those "weight-neutral" APs.    I'm trying to be better about my diet to help make sure that I don't gain weight on the Latuda, especially after seeing how much better I look and feel at 140.   I also tend to ask my pdoc about whether something is weight neutral or not, but Parapluie's right - it'd be nice for most of them to mention diet and cravings, etc.

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Abilify has not been weight neutral for me. I've gained 30 lbs on Abilify.

 

I really wish doctors and nurses would counsel patients on the side effects of APs. Just sit down and take 5 or so extra minutes to explain that APs might affect your appetite, you may gain weight and how to avoid that weight gain. Discuss topics like eating healthy on an AP and the importance of exercise. Talk about the cravings APs might give you. Stuff like that. 

 

I'm seeing my doctor this week to talk about adding metformin to help me lose weight. We are also reducing my dose, hopefully down to 10 mg, down from 30 mg. We are trying to find the best dose that controls my symptoms, with the least amount of side effects. I also experience intense sedation on Abilify, sleeping an average of 12 hours a night. Which obviously is not going to help me lose weight!

 

I found that the dose reduction from 30 mg to 20 mg really curbed my appetite. Abilify gives me intense sugar cravings, but reducing the dose really helped with that. I have hopes that reducing the dose further and adding metformin will really control my appetite and weight gain. 

 

In the end, if reducing the dose and adding metformin doesn't stop me from gaining, then I'm going to talk to my doctor about changing anti-psychotics. Really, my goal is to just stop gaining. 

Sorry to hear about your weight gain with Abilify. My current doctor claims it's not weight neutral but all the other doctors that prescribed it insisted it was. The only time I didn't gain weight on it was when I took 1-2mg( which isn't much of a dose) and was also on 400mg of Topamax, plus adderall and some other stuff. Was anorexic at the time, so my caloric consumption was minimal. Needless to say it didn't work. I can't remember what my dose was when I gained weight on it, much higher though and that was before I became psychotic.I was severly depressed at the time.They took me off it when I went to rehab, said it made me too out of it, dulled me too much, that I didn't need it since I wasn't psychotic. I was relieved to be off it and lost a lot of weight afterwards. I think another doctor prescribed it after the auditory hallucinations started, something like 5-10mg, and I gained a  a couple of pounds, so I went off it after a couple of weeks. Was anorexic then too but my weight wasn't quite as low. It never helped with my voices, but then I wouldn't let doctors put me on a very high dose b/c I knew it would cause weight gain.

 

Good luck with the dose reduction and Metformin. Both should help some. Have you gained weight on other supposedly weight neutral AP's? I know it varies so much with each person. I never gained weight on Seroquel, which is surprising. With the exception of Clozaril, I always seem to gain more weight on the weight neutral AP's.

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I haven't gained weight on Latuda, but I'm very nervous about it, so I'm being a little more cautious with what I eat.  (Admittedly, my developing a gluten intolerance has helped with that.)  I usually gain weight on the weight-neutral meds too - my psychiatrist was shocked at how much I gained on the Geodon when I was on it years ago - I went from being 175ish to about 350.  NOT good, and will never take that stuff again.   It went away when I stopped it, so I think I'm allowed to be a little leery of those "weight-neutral" APs.    I'm trying to be better about my diet to help make sure that I don't gain weight on the Latuda, especially after seeing how much better I look and feel at 140.   I also tend to ask my pdoc about whether something is weight neutral or not, but Parapluie's right - it'd be nice for most of them to mention diet and cravings, etc.

I wonder what causes some of us to gain weight on the weight neutral AP's? Have you also gained weight on the AP's that are known for weight gain? With the exception of Clozaril, I haven't gained as weight on them, they just never worked. I gave Zyprexa a brief chance, gained a couple of pounds and went off- but Seroquel, Risperdol, Perphenazine, and Fanapt( which I can't recall if it's weight neutral, I had horrific other side effects) never caused weight gain. Why would meds known to cause weight gain not cause it and then the ones not supposed to cause it, make me gain weight? Just wondering if anybody else has had a smiliar experience. Frankly I think they all cause weight gain sometimes, and doctors have no idea what's going to happen. it just varies on the individual. I read a study yeasterday that mentioned something about a genetic predisposition for weight gain on AP's. Too bad I didn't bookmark it.

Glad you were able to get off the Geodon and lose the weight. I wasn't on Geodon long, but I started gaining weight rapidly and it didn't work, so I went off it ( with my doctor's permission). Good to know the Latuda is working for you. I'm hoping with my new low carb diet, eating 3 small meals a day, and Metformin, I'll see some results. I'm just looking to lose a little weigh. Don't want to become anorexic again. My main goal is to avoid further weight gain. We shall see.

 

My doctor was really good discussing weight issues and AP's with me, but not until I brought up my concerns.I think I got extra attention because of my history with anorexia, but she seemed happy to help me work out a diet plan and spent 45 minutes with me, when it's normally just a 10-15 minute med check. I really appreciate that. She's not the first doctor to do it, but she's the first Pdoc to do it when I've been at a normal weight. Most of my Pdoc's discuss nutrition and eating with me when I'm underweight only. I think doctor's assume if you're a normal weight that everything is fine, unless you tell them otherswise. I certainly never got the how to lose weight on AP's lecture because nobody wanted me restricting more than I already was when i was anorexic.Now that my weight is healthy, my doctor was happy to give me pointers for weight loss on AP's, as long as I promised to eat 3 healthy meals a day since I can lose weight and still be comfortably in normal range. Maybe because of my ED history, my doctors have tended to focus on diet more in my sessions.

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  • 5 months later...

 

I lost a lot of weight on Latuda. Was on a low fat, low carbs, almost no sugar diet with lots of exercise. Basically, my version of the diabetic diet. I've gained some of it back, unfortunately, when I relaxed too much. (Many self-reprimands!)

 

Latuda does not stop me from loosing weight. However, I would guess that all AAPs require me to eat less and exercise more than if I was not on them. Or maybe it is just that my metabolism changed. That happens as we age. There's an increment that comes with each decade milestone. ;)

 

Seroquel and Depakote caused me to gain a lot of weight quickly. I ended up with type II diabetes after psych meds when I wasn't even close before them. That may be a factor in difficulty loosing weight. Not sure. Also not sure about other AAPs except for Risperdal, which I did not gain on, but I could not loose.

 

I think eating like a diabetic is the best way to minimalize weight gain on AP's since they increase blood sugar. I used to eat like a diabetic when I was anorexic. I relaxed and allowed myself to consume carbs again once I was in recovery from anorexia because I didn't want to be so restrictive and worry about food. I still ate a fairly low calorie diet, so i didn't think it would make that much of a difference, but I think you really have to be careful with sugar when you're on an AP. After getting weighed at the GP's last week and freaking out, and having a long talk with with Pdoc, I have decided to go with a high protein diet. I'm eating  a small all protein breakfast and lunch and then a small dinner. I'm not going to cut out all carbs, but will try to eat mostly vegetables and protein at dinner. I'll still allow myself to eat some complex carbs at dinner, but no more yogurt, bread, pasta, or orange juice except on special occassions. And I get to have a slice of pizza once a week.I can't go back to excessive restricting because I could easily get out of control again, and I don't want that. Eating 3 times a day is scary, but my meals are small and it means I eat a smaller dinner, which is helpful. Hopefully with the dietary changes and Metformin, I'll be able to drop about 5-8 lbs or so ( not looking to loose more than that, don't want to slide back into anorexic mode) and avoid future weight gain.

 

 

How has this worked for you? Also former ketogenic diet anorexic. I lost tremendous weight after each depression-related treatment with Zyprexa. I've been treated for Bipolar disorder for 17 years, so plenty of experience with the AP related weight gain, and maintaining a very low body weight when they're not on the menu.

 

Due to heavy cycling in December, I've taken it nearly every day gaining 15lbs (115-130) since. I started basic Atkins style, and then after experiencing no weight change went ketogenic a 2 weeks ago. I've had no change in weight, but no loss. When I'm not on Zyprexa, this diet gives me a 3#/week loss.

 

My concern is that I'm continuing to use Zyprexa. Has your diet helped? 

 

Interestingly, my blood sugar is in the <72-93> range, fasting & after meals. I'm also on Metformin and a low carb (thus low sugar) diet, however Zyprexa initially causes low blood sugar, hence the overwhelming hunger. 

 

The fat-effect is Zyprexa's direct tissue effect on insulin, so regardless of your dietary sugar intake, the insulin, which causes fatness, is rampant and not functioning properly. Regardless of that enormously depressing fact, there's a strong correlation between my weight stall and a very low carb diet - I assume the not adding dietary insulin on top of the Zyprexa induced insulin resistance, has helped prevent insane gain. Maybe :)

 

I had movement problems with Latuda, and it made me more solemn than Zyprexa - the pros didn't meet the cons. As you know, though, weight gain, especially for someone who really enjoys having a slim, fit frame, has me on the edge. 

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I should also note I'm taking Belviq, which has done amazing things for the crazy-monster of appetite. Seriously a miracle.

 

I have tried T/Dopamax, but stopped immediately after a horrific short term memory lapse - Moment of Panic: suddenly didn't know the day/time and couldn't remember if I picked my kids up from school. I had, indeed, picked them up, dropped them off, taken the dog for a walk to pick up my px and started to cook dinner. Wow. That was with low dose - gradual increase titeration. Pretty nuts! 

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I've been on Latuda for 3 years and haven't gained a pound. I haven't lost weight either, but then again, I've not really tried. Gaining 5 lbs from a med is not all that serious, in my opinion. Honestly with  your history of eating disorder, I wonder if you are maybe taking the weight gain a bit out of unhealthy context.

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