Puddles2009 Posted December 25, 2013 Share Posted December 25, 2013 Hey guys i found a multi drug checking tool on this website and i decided to use it and it came up with the following stuff Most of it i understand but some of it really confuses me, is anyone able to help chlorpromazine + paliperidone chlorpromazine and paliperidone both increase QTc interval. Significant - Monitor Closely. chlorpromazine + paliperidone chlorpromazine and paliperidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Significant - Monitor Closely. diazepam + chlorpromazine diazepam and chlorpromazine both increase sedation. Significant - Monitor Closely. diazepam + paliperidone diazepam and paliperidone both increase sedation. Significant - Monitor Closely. chlorpromazine + paliperidone chlorpromazine and paliperidone both increase sedation. Significant - Monitor Closely. trihexyphenidyl + chlorpromazine trihexyphenidyl decreases levels of chlorpromazine by pharmacodynamic antagonism. Significant - Monitor Closely. chlorpromazine + trihexyphenidyl chlorpromazine increases effects of trihexyphenidyl by pharmacodynamic synergism. Significant - Monitor Closely. Potential for additive anticholinergic effects. Link to comment Share on other sites More sharing options...
hagar Posted December 25, 2013 Share Posted December 25, 2013 Looks like it's just a list of theoretically possible reactions from interacting drugs. I wouldn't sweat it too much, but if any of them worry you, call your doc and inquire about them. Link to comment Share on other sites More sharing options...
jt07 Posted December 25, 2013 Share Posted December 25, 2013 Most of these are not worrisome at all. I'm sure your doctors are well aware of these potential interactions. The only one that I would ask the doctor about is the QTc interval thing, but it certainly is not worth panicking as most people on these meds have absolutely no problem with the QTc interval. Link to comment Share on other sites More sharing options...
Wooster Posted December 25, 2013 Share Posted December 25, 2013 What it means is that I think you are obsessing about your meds. Start a list of questions to take to your next doctor's appointment. QT interval is a rare thing that has to do with the length of segments of your heartbeat. If you keep researching it, my guess is that you'll start to wonder if you have it, and that won't help you want to stay on your meds. EPS and NMS are things you will know if you have because you will have distinctive symptoms that you will KNOW aren't right. Have you ever broken a bone? There's a certain kind of pain that comes with having broken a bone that is very different than having just sprained a joint. Most of the side effects you have are like having sprains... they're not going to kill you or cause permanent damage. They're annoying and uncomfortable, but not dangerous. Things like QT interval, EPS, NMS, etc... you will KNOW if you have them. Link to comment Share on other sites More sharing options...
San Posted December 25, 2013 Share Posted December 25, 2013 The pharmacy checks for severe drug interactions before giving you the meds. Trust me on this. I sat for 3 hours at a pharmacy once because there was an interaction and they had to fax back and forth to my pdoc, I had to run forms back and forth (pharmacy was in his office). An online interaction checker isn't checking doses, and the pharmacy checks everything, so does the doctor. If the pharmacy thought the risk was really bad, they would have not given you the prescription. Trust me, I've had it happen. I've had prescriptions swapped while waiting for the pharmacy to fill it. Link to comment Share on other sites More sharing options...
mcjimjam Posted December 26, 2013 Share Posted December 26, 2013 I agree with everyone else. One of the reasons a psychiatrist and a pharmacist are necessary for you to get your meds is because they have the skills to decide whether a combination is safe. A drug interaction checker is just something that allows you to search and combine potential interactions for a set of meds. It takes medical knowledge to be able to interpret the results and decide whether they are worrying. If I put in my meds I get a whole list of interactions, too. Probably most people here would. Link to comment Share on other sites More sharing options...
Puddles2009 Posted December 26, 2013 Author Share Posted December 26, 2013 Oh o no worries then, thanks all Link to comment Share on other sites More sharing options...
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