Equivilency Posted March 21, 2014 Share Posted March 21, 2014 Those of you taking Wellbutrin XL how long did it take to kick in? I'm on week 2 and i've noticed absolutely nothing. I'm still mentally and physically exhausted. I read sometimes it takes 6 weeks. That's an awfully long time. When I was on Cymbalta, it kicked in after the first dose! Link to comment Share on other sites More sharing options...
olga Posted March 21, 2014 Share Posted March 21, 2014 Everyone is so different. When I took Cymbalta, it was 6 to 8 weeks before I began to feel the difference. It was a good anti-depressant for me, but seemed to take forever to kick in. WellbutrinXL is also an AD, so if I were you, I wouldn't expect it to do anything for exhaustion---mental or physical. I've been on it for 7 or 8 years now, but I feel that it's treating my depression. If I'm physically tired, I need to rest, or exercise more, or get my iron level checked, or eat healthier food. I felt its effect as an AD rather rapidly, but I'm taking 300mg. I don't think I felt any different when I was taking 150mg. Will your doctor be having you take 300mg at some point? I don't have Schizoaffective Disorder, so I don't know what dosage is usual for your diagnosis. olga Link to comment Share on other sites More sharing options...
wj74 Posted March 21, 2014 Share Posted March 21, 2014 It's hard to say for me because my dx isn't depression. But when I started taking Wellbutrin XL it took a few weeks to go hypomanic. So I'm going to assume that if I were primarily depressed, it would have kicked in about then. Link to comment Share on other sites More sharing options...
lysergia Posted March 21, 2014 Share Posted March 21, 2014 i just restarted wellbutrin XL a few months ago (it has pooped out on me once before years ago, this is my second time trying it). i felt a little something after the first few weeks, but not much. i was surprised too, because last time after two weeks it was GREAT. this time, it's taken the whole 6-8 weeks before i could tell it was working. i'm not as "exhausted" as i was - i'm still depressed, but it's easier to do the things that help me feel better like getting out walking and being with people and stuff. i hope it works for you, soon. Link to comment Share on other sites More sharing options...
Ang51206 Posted March 21, 2014 Share Posted March 21, 2014 I take wellbutrin and it took about six to eight weeks to completely take effect. That's when it got to the awesome side effect of wanting and really enjoying sex ALL THE TIME. My husband says I'm going thru puberty again lol. Link to comment Share on other sites More sharing options...
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