From Lexapro & Strattera to Effexor XR and Seroquel?

[chromegirl]

MDD (moderate) and GAD here.  After going downhill over the last 6 mo, my new pdoc just made a sudden switch from Lexapro 10 mg, and Strattera 40 mg, to 75 mg Effexor XR and Seroquel (50 mg the first week, then we bump up to 100 mg).  This is a new pdoc for me...my old one would have never changed this many things at once.  

 

So far though I am not noticing anything major, good or bad.  The first morning after taking the Seroquel (I also have been taking Trazodone to sleep...though she cut that from 150mg to 100 mg since adding the Seroquel) I got the classic hangover after an epic 12 hr sleep.  The next night and morning though were totally normal, I had no problems getting up and moving and had a good sleep.  Now on day 5 and that has continued, easy to get up and I do feel rested, which is great.  Tomorrow night though I double the Seroquel to 100 mg....am I going to be a zombie Friday morning?  

 

Also curious about alcohol on this combination...I am not a big drinker but I do like to have a couple of glasses on a Friday night after a long work week.  I would do this on my previous meds without a problem, I never drank to excess.  Just wondering how this would work with Eff and Seroquel. 

 

Thanks all.

 

 

[chromegirl]

As of tomorrow I am two weeks in to this new combination.  I survived the jump from 50 to 100 mg of Seroquel well...well in that I am managing to get out of bed without too much difficulty.  Still sleeping really well, which is good.

 

As for depression and anxiety...the acute anxiety I was prone to feeling is pretty much gone.  The depression seems to be a slower grind- I feel pretty blah in the morning, but I can make myself get up and start my day.  By the time I am done work, I am feeling ok.  Not so sure if I would go so far as to call it 'happy'...but definitely better than how I feel first thing in the morning.  I can function and get the basics done.  

 

I feel like I have a ways to go, but it has only been two weeks after all...hoping that this is all progress.  And I go back to the pdoc in 12 days, which is good.

 

I am trying to be patient with myself...baby steps...but it is hard.