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I am on regular Seroquel. I like that I take it at night and can sleep well with it. The xr would make me concerned I would be drowsy.

I think and don't quote me on this, that it's about level in your system, so that it works either way. It works well for me.

Just noticed your dosage, I am at 500mg, and it's not for sleep, its more for mood stablization and as an atypical anti psychotic in my case.

Edited by dragonfly23
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I took 800 mg of the IR. I took 200 am, 200 pm, and 400 mg bedtime. I've taken it 4 times a day though as well and split the afternoon dose up for better anxiety control as my pdoc is against anyone using benzos. I have never tried the XR but was on the IR for years. I slept very well. Now that I'm completely off of it and on latuda I don't sleep that well unfortunately. I wake up a lot and can't fall asleep very well. It is a very good med. I just couldn't deal with the side effects I was having anymore.

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I take it this is not a question about the half life of Seroquel, but rather a question about how the two differ in their effects?


I'm on both, have been for years. I take the IR at bedtime, or as a PRN for breakthrough anxiety or incipient mania, and it works quite well as a sedative. I take the XR as an anti-depressant/mood stabilizer/anxiolitic add-on, and it works quite well in that capacity too, without the annoying drowsiness. Any XR/CR/ER sort of formulation is designed to keep the medication in your blood longer so you get a more steady dose.


I split my XR dose, 100 mgs in the morning, say 11:00 a.m., and 50 mgs at bedtime, about 11:00 p.m. I prefer the larger dose in the morning, because as I said, it doesn't make me drowsy, and I need the sanity more when I'm awake than when I'm asleep.

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