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So about 5pm every day of late, my mood just turns black. I can't buy a neutral (forget positive) cognition or emotion, I start to feel and think very negatively no matter what I do. Of course, I'm feeling and thinking badly beforehand, but it just sinks to another level, or depth if you will.
So I'm wondering if it's a med (or meds) that I'm taking that's losing effect around 5pm. I take the following meds - yes, it's a crazy-looking brew I know, but it allows me to function somewhat - at 6am (in milligrams):
200 Provigil, 2.5 Abilify, 40 Fetzima, 30 Lexapro, 15 BuSpar, 150 Lyrica, 10 Percocet and these at 2pm:
150 Lyrica, 15 BuSpar and these 4 times a day, where the last dose is typically 2pm:
15 Adderall 10 Percocet (for chronic pain) and these at 7pm for sleep:
150 Trazodone, 50 Benedryl It's impossible to confidently predict a "culprit" but if anyone has any hunches, I'd love to hear them.
For example, today I'm splitting (some of) the 6am batch into two and taking the second half at 2pm as an experiment. I feel that empirical experimentation might be the way to go because the theory is too complex with this many psychotropic medications in play.
Cheers , Pete
Been on Effexor (again) 4 months. Went up to 225mg, but the lethargy and apathy was getting worse, along with excessive sweating. I'm typically someone that runs more cold (usually takes a lot for me to sweat at all!) So this is upsetting. I've started working out everyday and after the warm-up, sweat is pouring down my face & neck. Sweat towel makes no difference. I get out of class and it looks like I just stepped out of shower.
At moment I'm on 112mg and this sweating persists. Would going down to 75mg be better?? Anyone recommend something with the least amount of side effects (especially no weight gain or lethargy) I'm thinking maybe just screw it, and going on something easy/basic like low-dose Prozac (also makes me sort of apathetic, guess I can't escape that)
I cannot take Glycopyrrolate (anticholinergic drug that reduces saliva, sweating, etc) because it worsens my severe dry eye syndrome & blurry vision. Lamictal + Ritalin have been moderately helpful (for stabilization, slight motivation) but I need a bit more antidepressant boost to cover some intermittent labile/low moods.
Anyone find Zoloft more motivating than Effexor? Any weight gain? (it made me insomniac with psychosis 20 years ago). But meds often act differently over time. I've already done trials (some multiple times) of:
Prozac (lethargic), Celexa (fatigue/apathy), Lexapro (similar to prozac), Cymbalta (vigilance/restlessness legs, but dissociative mind/feeling), Wellbutrin (no effect), Trintillex (no effect), Remeron (sedating/+appetite), Notryptaline (don't recall), Abilify (++appetite, RLS), ..Doc won't RX MAOIs and says that TCAs typically more sedating effects.
Basically, I don't want to take more than 3 meds (keeping with Lamictal & Ritalin). I want to avoid A/Ps...I like the calming feeling of Prozac & Effexor, but it's as if I am in this fuzzy cloud and I can't move or do anything, comfortably numb. Totally apathetic, in addition to sexual dysfunction, maybe my dosage is wrong. I'm also considering Viibryd, but don't know if it works on Serotonin...?
Only Day 2 back on Effexor (I took previously for 7 months at 150mg, but don't remember much). I've literally been laying in bed, blank-minded, just staring at the wall for 3 hours. This is really not normal for me, I slept well last night (9 hours) and was up, OK & out walking earlier. I'm only on 37.5mg!...It's only Day 2! I'm shocked that I would feel effect immediately.
Haven't felt this tired, heavy and zoned out for a loooong time. In fact, I don't recall feeling this numb since Citalopram or when I was on Cymbalta a decade ago. I've been consistently taking Ritalin , I had 3 coffees today....and the Effexor (obviously) has completely wiped out any stimulant effect.
I mean, it's nice to not be over-emotional, stressed with crying jags, but on other hand, I don't want to be flatlined, lifeless, unable to get out of bed, no cares about anything. Please tell me this is temporary and will go away in 1-2 weeks or with a dose increase?? Does anyone know the dosage breakdown of Effexor? (for example: 37mg-75mg works on Serotonin....75mg-150mg works on Norepinephrine, etc?) I feel Serotonin overload, I thought that Effexor worked on 3 transmitters at once...
I can't seem to find the right combo balance with anything (all SSRIs made me feel like this too) and many other meds are too sedating or they do nothing for me. Any thoughts? @browri @mikl_pls ?