I feel like this combo is cancelling everything out (Wellbutrin, Remeron, Seroquel)

[mywarmbluefleece]

I was on Prozac, Remeron (15 mg), and Seroquel (200-250 mg) for a while but my depression (particularly anhedonia) is still really severe.  I'm having trouble functioning.

 

I've been on Seroquel for a long time and it's really helped me. At one point, it was all I was on. We added Remeron 15 mg, and at some point I'll probably have to go up because it's not quite working enough. The Remeron and Seroquel helped me sleep very well and I felt stable and calm on that combination.  But I had no motivation and severe anhedonia so the dr added Wellbutrin.  

 

I've been on it twice before, once when I was younger, and the second time a year ago and it was great the first time but the second time I had really severe anxiety with mild paranoia and agitation. We thought the other meds would cancel that effect out of the Wellbutrin, but I am so agitated. I unintentionally gripped my bf so hard today when I was trying to calm myself down that I broke his skin.

 

My dr. wants me to try until Wednesday. I started last Saturday. 

At what point should I stop? What level of agitation or anxiety is just too much?

Do these meds cancel each other out?

I've been mood disorder NOS in the past but this dr doesn't think I have that. He's still working at finding out a diagnosis, so unfortunately I can't help too much with that. It's depression and anxiety to really simplify it, with a lot of other symptoms.

[SpookyCrow]

Fleece I don't think anyone can really tell you how much is too much. With that in mind I'd like to encourage you to stick it out for the 4 days if possible.

[jt07]

I agree. I'd try to stick it out until Wednesday if I possibly could. It might just be your body adjusting to the addition Wellbutrin to the combo.

[mywarmbluefleece]

Thanks for the encouragement. I really want this to work but I'm just so miserable right now.

[water]

What type of wellbutrin are you taking? Is it the 150XL, right? Not the IR, immediate release.

And are you taking the brand? If not, I would take the brand. It does a better job, at least for those of us extremely med sensitive, in letting out the bupropion slowly thruout the day, which has a huge effect on how the drug does. An older relative was given 150 IR, which dumps out the med in one fell swoop, it screwed him up so much it took decades before he was willing to try again. 

 

Even so, when I started wellbutrin, I was very hyped up. It does take some time to adjust. 

Cut out all caffeine. Drink lots of chamomile tea. 

 

There really is no way to tell how you will do unless you give the med more time.

[mywarmbluefleece]

It's XL. Klonopin and extra Seroquel are not evening out the anxiety/ agitated feeling. I'm really trying to make it to Wednesday but I'm starting to be concerned about my wellbeing.

[water]

It's XL. Klonopin and extra Seroquel are not evening out the anxiety/ agitated feeling. I'm really trying to make it to Wednesday but I'm starting to be concerned about my wellbeing.

 

 

I just re-read your first post. I didn't realize that the second time you stopped taking it was because of this very reason.

I do know that this is a very common side effect.

But if it is getting worse by the day, that is not good. 

 

You said the doc put you on Wellbutrin because of no motivation and anhedonia.  did the lack of motivation and anhedonia develop after taking Seroquel?

 

There are many other meds to try. Perhaps Wellbutrin and you do not 'meet cute'. 

 

Wellbutrin was the very first AD I ever took. And the effect was instantaneous and overwhelming. I couldn't even drive. There were good and bad initial side effects. but eventually the good way out weighed the bad.

[Wonderful.Cheese]

I can't handle the stimulation of Wellbutrin. I agree with water that it is a common side effect. How are you doing today?

[mywarmbluefleece]

 

It's XL. Klonopin and extra Seroquel are not evening out the anxiety/ agitated feeling. I'm really trying to make it to Wednesday but I'm starting to be concerned about my wellbeing.

 

 

I just re-read your first post. I didn't realize that the second time you stopped taking it was because of this very reason.

I do know that this is a very common side effect.

But if it is getting worse by the day, that is not good. 

 

You said the doc put you on Wellbutrin because of no motivation and anhedonia.  did the lack of motivation and anhedonia develop after taking Seroquel?

 

There are many other meds to try. Perhaps Wellbutrin and you do not 'meet cute'. 

 

Wellbutrin was the very first AD I ever took. And the effect was instantaneous and overwhelming. I couldn't even drive. There were good and bad initial side effects. but eventually the good way out weighed the bad.

 

The anhedonia started at least 10 years ago, because in college was the first time I remember hearing that word. I've had depression and anxiety most of my life. If anything, the Seroquel has helped, because I'm not overwhelmingly terrified constantly- it makes it easier to do things.I took a 3 hour nap and woke up realizing I am also PMSing so that may be a small sliver of the problem.

[mywarmbluefleece]

I can't handle the stimulation of Wellbutrin. I agree with water that it is a common side effect. How are you doing today?

I had a little bit of a meltdown this morning, and took a 3 hour nap. I feel a little better now. I also realized I am PMSing, though its not normally even 1/10th of this, it could be complicating this.