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I have been reading a bit about orphenadrine, which is a muscle relaxant that is a close cousin to some familiar psych meds (it was derived from diphenhydramine, better known as Benadryl). There is some evidence that it has antidepressant effects, which interests me. It's also used to combat EPS from antipsychotics, and I think the anticholinergic effect might help me with my drug-induced tremor.

I have myofascial pain syndrome, which is a muscle pain disorder. I have already tried the following:

Zanaflex/tizanidine - did nothing, even at doses up to 12mg

baclofen - did nothing but made me feel drunk and woozy at higher doses ~60mg

Soma/carisoprodol - did nothing

Flexeril/cyclobenzaprine - did nothing

Valium was the only thing that worked as a muscle relaxant for a while, but I get tolerant to benzos very quickly and require higher and higher doses to achieve pain relief, so they can't be a long term solution.

Does anyone have experience with Norflex (orphenadrine) for muscle pain? I'd love to hear your experiences.

Edited by larkspur
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I have had experience with orphenadrine, and it worked for skeletal muscles but it didn't really get rid of/help with tension headaches.  It did help a little though. It was not as strong (IMO) as other muscle relaxers.  No side effects from it.

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I have had experience with orphenadrine, and it worked for skeletal muscles but it didn't really get rid of/help with tension headaches.  It did help a little though. It was not as strong (IMO) as other muscle relaxers.  No side effects from it.

​Do you recall it having any effect on your mood?

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I have had experience with orphenadrine, and it worked for skeletal muscles but it didn't really get rid of/help with tension headaches.  It did help a little though. It was not as strong (IMO) as other muscle relaxers.  No side effects from it.

​Do you recall it having any effect on your mood?

​No effect on my mood.

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Chronic everyday pain. I carry a lot of anxious tension in my body to begin with, couple that with myofasical trigger points and it's no fun. I'm looking for something to take daily and reduce my overall pain level.

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Chronic everyday pain. I carry a lot of anxious tension in my body to begin with, couple that with myofasical trigger points and it's no fun. I'm looking for something to take daily and reduce my overall pain level.

​I have chronic pain as well. Have you consider pain patches? I have one, and it last for a week. It does a pretty good job. I def don't have to take so many Norco with it. Pain patches offer a more long term solution, even though I still have to take pain pills, I'd be taking a hell of alot more without the patch. There are a wide range of different kind of pain patches too. I'm on the Butrans patch, which delivers a steady dose of buprenorphine into my system. It's only a Schedule 3 drug, where as my pain pills(Norco) is a Schedule 2. Just something I thought you might want to look into. I know it helped me a great deal.

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I was actually on fentanyl and Percocet before, and the withdrawal from that fentanyl patch was NOT worth it. My pain tolerance now is much reduced, to the point where the blood pressure cuff at the doctor's office makes me cry, it hurts so bad. I want to avoid opiates if I can. I'm glad Butrans works for you!

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A fentanyl patch  would be way too strong for me. And Percocet, ugh! For some reason, every time I've been prescribed that(after surgeries), it always made me throw up. Hydrocodone is much nicer to me. I understand wanting to avoid opiates though. I avoided them as long as I could, but eventually the pain got so bad I had no other choice. Muscle relaxer never worked for me. Have you taken Tramadol?

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Tramadol is contraindicated with serotonergic drugs due to the risk of serotonin syndrome. I already take lithium, Adderall, and two antidepressants. Tramadol is a no-go. 

Hydrocodone makes me vomit profusely. Oxycodone is just fine for my stomach. I much prefer oxy to Vicodin.

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That's so odd. It's the complete over way around for me. Oxy makes me vomit profusely and Hydro is fine for me. Ok, one last suggestion. Have you tried Neurotin? I was on that for nerve pain for a couple months, and from what I've learned here, it's also used for mood stabilization. 

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