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Hi all !!

So I've been tapering off Quetiapine for a good while now, as my only bout of severe depression has been in remission since 2011, and am now on 87.5mg. 

Four weeks ago, I believe I suffered a concussion/mild brain trauma from boxing, my cognitive functions have suffered significantly and I've had bad anxiety/depressive thoughts too - my pdoc is viweing this is a flare up of my past depression which needs resovling ASAP. So I was offered Paroxetine, then Venlafaxine, I really wanted Wellbutrin because it has the least reported sexual dysfunction issues and may help with mental sharpness. Pdoc wasn't sure, so in the end I've been prescribed Trazodone 150mg at night - along with the existing Quetiapine dose!

I woke up at 4am feeling like I was drowning / suffocating inside my own body and my mind was actually racing for a while before I zonked out back to sleep. I eventually came to around 8am feeling really groggy and struggled dizzily to the bathroom mirror - my eyes were a mess, I looked as if I had been on a huge night out on the town. I've not been able to think properly all day, there was no way I would have been able to function in work and in light of the fact that I believe I am already suffering cognitive impairment from the concussion, over sedation is the absolute last thing I need.

At one point I had a really bad migraine type headache, which I never get, so I managed to speak to Pdoc, who eventually suggested cutting the pills in half, then review the over-sedation issue Friday. My gut feel is Quetiapine combined with Trazodone is heavy duty.

If its still an issue, it looks Venlafaxine at 75mg/d, though he conceded to looking into the possibility of Wellbutrin too (largely subject to establishing any contra-indications with Quetiapine). All I know is I cant take any more Trazodone tonight and will start 75mg tomorrow evening to see how I get on - if I return to a state of non-complis mentis on Thursday, they are going in the bin. This basically leaves the pdocs preferred choice of Venlafaxine, or possibly the Wellbutrin; 

  • Does anyone have any experience with Trazodone and Quetiapine combined? 
  • How about any opinions on Venlafaxine and sexual dysfunction?
  • What experience do people have with Wellbutrin in terms of its anti-depressant / anxiety efficacy or mental lucidity and whether it impacted sleep?
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  • 1 month later...

I'm currently taking a low dose of quetiapine and mitrazapine (similar sleep aid) which both have a moderate interaction with each other. It just gets me more tired and I slur a bit when I take my meds at night. I believe the interaction would be very similar.  

Hopefully I'll get off the mitrazapine and get back on a proper dose to quetipine which helped me be stable and sleep

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