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article on treatment for refractory OCD

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I found this while researching N-A-C (N-Acetyl-L-Cysteine) which is an amino acid i take that helps the liver to do its thing and is a good anti-oxidant.

N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder.

Psychopharmacology (Berl). 2005 Dec 22;:1-3 

    N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder.

    Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V.

    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

    RATIONALE: Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid compound that is thought to attenuate glutamatergic neurotransmission. NAC may be useful in treating psychiatric disorders involving glutamatergic dysfunction such as OCD. OBJECTIVES: To examine the efficacy of augmentation with NAC in a patient with serotonin reuptake inhibitor (SRI)-refractory OCD.METHODS: A patient with SRI-refractory OCD was treated with an off-label use of NAC augmentation of fluvoxamine over several weeks. RESULTS: NAC augmentation of fluvoxamine resulted in a marked decrease in Yale-Brown Obsessive Compulsive Scale (Y-BBOCS) score and a clinically significant improvement in OCD symptoms. CONCLUSIONS: NAC augmentation was effective in treating SRI-refractory OCD in this single case. Further research is warranted to investigate the use of NAC and other glutamate modulating agents in the treatment of OCD.

(bold added by me)

I thought that the fact that it seemed to help treatment resistant patients by helping SSRIs work might be interesting to some of you... perhaps something to talk to your doctor about if the SSRIs aren't helping the OCD enough.

take care,


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