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Is it time to give up on Zoloft? Sudden depressive ep.


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So a quick background: I've had depression and anxiety since I was very young, and was diagnosed in my early teens (I'm in my 20s now). Family history of depression is a mile long, everyone else takes Prozac. Prozac made me suicidal (and more depressed, etc). So Pdoc switched to Zoloft, which combined with Concerta made for a pretty good couple of years. I've been on a whole range of Zoloft dosages (as high as 175mg+, as low as 37.5). Higher doses seemed to just turn me into a zombie, but all in all it's been better than me unmedicated, so we titrated down (and then bumped up after I got my 4th concussion this winter and had related psych symptoms). Seasonal affective disorder also seems to be a thing, so I have a lightbox. 

Despite the concussion, I was feeling pretty good until late August/early September. I started out thinking it was just a little episode (I tend to have a minor episode every August, for some reason) and it seemed to resolve until 2.5 weeks ago, where I suddenly felt like shit. Complete lack of interest in schoolwork (I'm a uni student), no desire to engage with friends (actively avoiding them at times), my appetite is gone, and I'm sleeping around 12 hours a night despite having trouble falling asleep (last major depressive episode came with insomnia, so sleeping a lot is strange for me). I slept through a 1pm class today. Obviously, I'm having trouble functioning, occasionally wonder if I should just take a leave of absence, and unlike previous minor depressive episodes while medicated, basic self-care has fallen by the wayside. I'm finally getting the nerve up to contact my Pdoc (who unfortunately is located far from where I go to school), because at first I thought it was just that I'd gotten sick and my feeling bad was just a reaction to the antibiotics (trimethoprim, aka Bacrim made me shake uncontrollably and not be able to eat). 

My Pdoc seems to do best when I come in with some idea as to what I want to do. So I'm wondering: does this sound like med poop out because of the fast onset etc? Or should we play around with upping the dose (of Zoloft I think--too much Concerta makes me shake+leads to dermatillomania/skin picking) and hope I don't turn into too much of a zombie? 

So, ideas? I'm tempted to say we should play with a new SSRI (lexapro maybe? I dunno) if a quick dose change doesn't help, cause Prozac again is too much of a risk and unfortunately wellbutrin (which pdoc hypothesizes would really help) isn't safe for me to take. 

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I was on zoloft for almost 10 yrs. I have bipolar depression. There's a long family history of depression and my grandfather had bipolar depression in my life. Zoloft worked well for me for a long time. I eventually became a zombie on it because I was on 200 mg of it. I had a very bad episode 2yrs ago when my cousin who was like my brother commited suicide. My pdoc said it was time for something new. It happened to me with paxil though too. I was on it for about 5 yrs then it just stopped working. I have the seasonal depression or whatever they call it when we have less daylight. Sometimes we build up like a tolerance to the meds. They just dont work anymore and we have to try something different. It's hard finding the right med because everyones body is different. Good luck with whatever road u decide to take whether it be working more with zoloft or trying something new. I hope I may have helped u a little. Take care

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