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Prozac stopped working due to a panic attack/trip, now I'm trying Paxil

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About two years ago I got extremely high with my friends, and tripped out, and had a huge panic attack (about level 8) long story short I was not the same after this happened, and ended up in the hospital because I thought I was physcotic. As it turned out I was diagnosed with ocd. I started off on Zoloft, it did nothing for me, it turns out my body was not reacting to the medicine, due to my genotypes (my therapist did a cheek swab test to see what medications could work). I then started on Prozac and about 2 months in I finally started feeling better again, although sleepy and lethargic all the time, my mind was quiet and I was content. Fast forward a year and a half, I'm smoking weed almost everyday with my friends until one day (about 5 weeks ago) I had a major panic attack/ trip again,(level 10) and the nightmare started all over again, my Prozac had been completely obliterated. My doc upped my mess to 50mg, and I had a few booster sessions in cbt but it was not working. My doc switched me to paxil about 3 and 1/2 weeks ago, and so far I haven't noticed much change. I'm just confused at why my Prozac would just stop, after working so well for over a year. I hope these new mess (Paxil) work, I'm just really mentally exhausted and want to escape my head. 

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