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I've been on trazodone (desyrel/molipaxin) for almost a year now. I take a low dose, 50 mg, and I also take 100 mg lamotrigine.Initially it worked fantastic. However, after about six months, my depression started to come back, up to the point where I feel really bad most of the time.  At least I still manage to go to work, and do my work properly.

But it feels like all the negative things in my life are weighing me down, to the point where it is consuming me, as if it is a constant presence in my chest. We are going through a difficult time in my country, droughts and heat waves, political clashes and riots, bad exchange rates, we're about to have food shortages etc., and I have a lot lf stress in my personal life as well, but it shouldn't affect one so much, right? To the point of thinking only about it? I'm also feeling really anxious at work, but at least it's not on anxiety attack level yet. At night I take xanax/xanor to cope.

So what I want to know is - is it my meds that are not working properly anymore, or is it just a rough patch? Will it pass? And what can I do to make it pass? I'm too tired to exercise, but I really want to...

Changing meds is really a big thing for me. So I don't want to do it unnecessarily. Maybe an increase in the trazodone eill help?  Any advice from someone who has been in a similar position?

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That is a lot of stress you are going through.  I'm sorry that is happening.

You might just need a med tweak.  Or maybe an increase in dose.  You wouldn't have to change meds, just increase the dose or need a med tweak.  My pdoc does this at times.  Have you told your pdoc how you are feeling? 

Do you have a therapist to talk to about all of the stressors you are dealing with?

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I live in the same country, and I work at one of the universities which has been hitting the news headlines.  My stress levels are through the roof, and I know what you mean when you speak about not being able to think about anything else.  I saw my pdoc last week - we've been trying to work to decrease my dose of clonazepam (rivotril), but she said that as long as I'm living in a shit storm (my words) and not really knowing what's going to happen at work from one day to the next, she doesn't want to touch it. 

My opinion is that you should definitely speak to your own doc.  We're living in tough, uncertain times, and as people with MI, I think we're extra prone to being triggered by difficult life circumstances.  I don't have any personal experience with trazodone, so I can't speak to that, but I can say that you shouldn't force yourself to struggle through without asking for help.

Take care, Mia

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I think Mia's advice is spot-on, and she said exactly what I was going to say, though I do need to add one thing: there is evidence that the more time someone spends depressed, the more likely they are to become depressed again in the future. Your brain builds and then reinforces neural pathways. Knowing this, I always feel as if I have to be particularly careful about how long I let any episode go on. Of course, my diagnosis is bipolar, not straight depression, so I have to be wary of mania on the other end of the equation, but it's the same principal.

You should talk to your doctor. Life stress depression is still depression. A med tweak might help.

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The only thing I can add is what has been alluded to and that is the doses of BOTH your trazadone and lamotrigine are low. Lamotrigine didn't even do anything at all for me until I was at 150 mg.

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Hi everyone, thanks for all of the feedback and kind words, it really helps a lot.

I emailed my pdoc  - we usually communicate via email and only have appointments once every six months, or if it is really an emergency. He responded and recommended that I increase my trazodone up to 100 mg for 2 weeks and then up to 150 mg. It's a big jump, I am a bit scared that it will make me freak out and go batshit crazy. But okay, I have to try something... If I increase the lamotrigine more, I get extremely tired and feel very lifeless. So I'll try increasing the trazodone first and see what happens.

Gearhead, I think you are definitely right, and it's just getting exponentially worse as time goes by, and this is now the second relapse in a year and a half period. The previous time was pretty bad, I hope it doesn't get worse :( 

Melissaw72, I don't see a therapist, because up to very recently, I never really had a reason to be depressed, if I can put it that way. I knew it was a chemical thing that pills would probably fix. Or maybe things didn't affect me as badly. But I really don't know if seeing a therapist will help, because most of the stuff going on is either out of my control, or will not change anytime soon. What do you think? I have the number of a psychologist, but I've never been to her. I just have to pluck up the courage to phone and make an appointment.

And MiaB, I'm glad I'm not the only one who is as seriously affected by the situation. Of course, it is bad for everyone, but it shouldn't ruin your internal life. Take care and stay safe. Hopefully everything will blow over soon and we can go back to work as normal.

Thanks again, everyone, your support means a lot to me :) 



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Melissaw72, I don't see a therapist, because up to very recently, I never really had a reason to be depressed, if I can put it that way. I knew it was a chemical thing that pills would probably fix. Or maybe things didn't affect me as badly. But I really don't know if seeing a therapist will help, because most of the stuff going on is either out of my control, or will not change anytime soon. What do you think? I have the number of a psychologist, but I've never been to her. I just have to pluck up the courage to phone and make an appointment.

Even though the stuff going on is out of your control, it might be  nice to have someone to vent too.  Just talking about it to someone can help.  When I was seeing a therapist, sometimes I just vented on everything going on, both stuff in my control and out of my control.  I always felt so much better leaving her office, calmer.

If it were me, I would definitely be calling the psychologist.

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