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Definitely not okay without discussing it with your doctor. 300mg is a very high dose for sertraline and could have all kinds of adverse effects. Plus, without a higher-dose prescription from your doctor, will you not run out if you continue taking the higher dose? Then you would have to go through withdrawal.

A safer approach would be to continue with the 200mg until seeing your doctor, and then speak to him about how it's not working anymore, and ask whether he would prescribe a higher dosage, or try a different medication. Most doctors are unlikely to be impressed with patients raising doses on their own; he is more likely to listen to you and be able to optimally help you if you follow his guidance and take meds at their prescribed dosages (though of course letting him know if they're not working)

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