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Seizures caused by Wellbutrin


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I had a series of seizures a year-and-a-half ago. I was on Lithium, Geodon, Provigil. Atenolol and Wellbutrin. The Neurologist feels strongly that it was the Wellbutrin (400 mg). Does anyone else have any thoughts? (Have been on Keppra to counteract the seizures since then but he wants to stop it.)

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I had a series of seizures a year-and-a-half ago. I was on Lithium, Geodon, Provigil. Atenolol and Wellbutrin. The Neurologist feels strongly that it was the Wellbutrin (400 mg). Does anyone else have any thoughts? (Have been on Keppra to counteract the seizures since then but he wants to stop it.)

I had a friend who had wellbutrin-induced seizures.  She too went on Keppra.  After (I think a year's worth) of clear eegs, her neuro tapered her off of the keppra and she has continued to be seizure free.

Have you been seizure free since comming off the wellbutrin?

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I'm pretty sure that while I was on Wellbutrin it lowered my seizure threshold (and as a result) contributed to my seizures...but I was on Effexor too and that I know makes me seize under the right (or wrong) conditions.

I'm just realizing that this post is getting murky and may be of no help to you whatsoever.

I suppose it's possible that they could have been med induced.  Mine were not.  I have had seizures all my life.

As Penny mentioned, it is possible to get off the drug that has caused the problems from the outset and be seizure free.

Karen

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My friend had serious seizures on Zyban (Wellbutrin)... With no prior history of them.

Just realized this is kind of a pointless post. I guess I wanted to say that it does happen, and it just might be the Wellbutrin that's causing them.

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  • 7 months later...

I had a Wellbutrin t/c without ever having a seizure before (as far as I know). Normal...which is it...eeg? The one where they put the wires on your head. Normal everything else.

I took an accidental double dose.

I don't think this thread is pointless as, years ago, I was looking for other people who had the experience.

I'm back on Wellbutrin, and am very careful about my dosing. It took years of no seizures and lots of treatment-resistant depression to get my Wellbutrin back. It's the only one that works for me.

One last thing - years ago, before the seizure, my doctor raised my dose to a bit over 400, and I had extreme jamais vu, which may or may not have been some sort of seizure episode. So, if anyone's getting jamais vu, and you really like your Wellbutrin, perhaps you should consider cutting back.

Also (perhaps it's obvious, but I considered myself tough, or something) - never take your Wellbutrin if you can't remember whether or not you've already done so.

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  • 8 months later...

i suffered my first and only absent seizure while weaning from wellbutrin 200mg a day to nada

it was terrifying and i cried and was hysterical for hours afterwards.

i was so scared; i now know how it feels to feel completely out of my mind.....and its was not pretty.

i "lost time" if you will

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Wellbutrin is the frickin' devil. Well, for me at least. It's fairly notorious for lowering the seizure threshold. For me, it caused the first seizure that was a big enough deal/weird enough to make me realize (retroactively, unfortunately) that something wasn't quite right. Partially blanking out at school in the hallway between classes and just sitting there on the floor for a couple minutes while the world decided to go back to normal and everyone else went to their classes convinced me to not try any other meds for a few years. Now we know that I'm apparently epileptic, and I take things that prevent seizures, not cause them. Heh.

Oh, and I just noticed the thing someone said last year about jamais vu. I get that all the time when I'm having seizures more often, so I can agree that that's probably not a good sign. Frequent/intense jamais vu/deja vu can be associated with your temporal lobes acting up. It can be a rather weird experience. I've been places that I go by/through more than once a week and not been able to figure out which city I'm in for a minute or two.

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My epi. specialist will not prescribe Wellbutrin to his patients he said becuz it has a reputation for lowering the seizure threshold. He likes Lexapro. However, it made me gain almost 10 lbs. in 2 months and didn't do shit for me but cause more simple partial seizures so I dumped the Lexapro in the toidy. Bah bye $45 co-pay. I TOLD him I wasn't depressed! I'm just pissed off cuz he said I couldn't drive unless I went six months without a complex partial seizure. Yeah, like that has happened since my DX. Better livin' thru chemistry my ass.

Anyway, to answer your question: Yes, Wellbutrin is well-known for making seizures happen...even in peeps who don't have epi.

Edited by dumdum
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  • 9 months later...

I'm new here, and although it seems that people haven't posted in this thread for awhile, this is exactly the discussion I was looking for. I actually did have a seizure a couple years ago right after my doctor increased my dosage of Wellbutrin (I had been against increasing it, because I felt fine...but my doctor insisted on giving me more). Of course, I had a seizure. I stopped taking the Wellbutrin immediately and never had a seizure again.

As for the med history, after I went off the Wellbutrin, I didn't take any seizure meds for 4 months. I didn't think I needed it. After those months my neurologist still suggested I go on seizure meds...so I went on Keppra. I've been on 250mg twice a day for about 8 months, and the past 2 months I've only taken the 250mg once a day. Now, I know Keppra is usually a supplement to another seizure med...and I also know that 250mg seems to be a dose that is too low to really make a difference...but either way I've been seizure free.

What I want now is to go back on the Wellbutrin XL at the lowest dosage. I've been depressed for a very long time and Wellbutrin made me feel normal and good again. What I'm wondering is if I should take the 250mg Keppra once a day when I start the Wellbutrin? I've been tapering off the Keppra because I haven't had seizures..but if I start Wellbutrin again should I keep taking it? I'm thinking that the less medication in your system, the better....but I'm not sure in this case. Are there any complications with taking Keppra and Wellbutrin at the same time?

Thank you sooooooooo much!

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Are there any complications with taking Keppra and Wellbutrin at the same time?

Well, they don't seem to interact with each other or anything, which is a good start. I would be surprised if the amount of Keppra you're taking is doing anything at all other than costing you money. 1000mg/day is generally the minimum dosage. I did notice something from 250, but that was taking 250 four times a day. It has such a short half-life that if you only take that little once a day, most of the day (where "12-18 hours out of the day" is my guess for how long "most of the day" is) there's probably so little of it left in your bloodstream that it's not doing anything. Unless you're special and way more sensitive to it than most people. Or have kidney damage and it doesn't get removed from your system as quickly. Heh.

As far as trying Wellbutrin again (at a dose lower than what caused problems), that may or may not be reasonable. You and your doctors know what happened then and what's happened since better than anyone else would. It is encouraging that nothing else out of the ordinary (seizure-wise) has happened since then, so they might be willing to try it again at a lower dosage. I very strongly doubt that 250mg/day of Keppra would help or hurt much, one way or the other, but everyone's brain is a beautiful and unique snowflake, so who knows?

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  • 2 months later...

Safety is the key issue here. Remaining seizure free should be your priority. Most agree that having multiple seizures is more detrimental to a person. However, living a life of darkness and despair doesn't seem like much of a half a gallon of your favorite ice cream. Wellbutrin has been proven to lower the seizure threshold in individuals, especially those who have suffered from seizures previously. I agree this should be discussed with your physician though maybe some compromise can be made so that you can start feeling "normal and good" again. Also, there is no drug to drug interaction between Wellbutrin and Keppra documented.

Finally, I'm sorry that someone forced medication upon you which had such an adverse effect. However, do not forget, is your choice to take medication despite how many prescriptions are written for you. It is best to review all of your medication with a single pharmacy/pharmacist so that drug drug interactions can be avoided.

I hope you do well with whatever decision you make. Wellbutrin is in a class of medication pretty much by itself though there are several alternatives in regards to antidepressants on the market which do not carry the warning of seizures.

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  • 3 months later...

On my second day of Wellbutrin I had a mini-seizure where the world turned sideways for a second. My neurologist had warned me about that, but I didn't believe him. No more for me!

From the PI sheet:

Seizures: Bupropion is associated with a dose-related risk of seizures

It is a 1 in 1,000 chance for Wellbutrin XL, 300 mg/day, which seems to be the common dose. It just sucks immensely to be that "lucky" on-in-a-thousand person. ;)

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  • 4 weeks later...
Guest NH Guest

Has anyone had anything similar occur to them?

My brother (21 yrs old) had his first tonic-clonic seizure two nights ago while he, my mother, and my wife and I were having dinner. It was the scariest thing I have ever been through, and fortunately he remembers nothing from it. It lasted 3 to 4 minutes, and he stopped breathing. I had to give him a quick steady tap on his back and he began inhaling again. Suddenly, he came to, and stared at me as if he didn't know me and started screaming. He charged me and tried to throw a chair, and continued to scream. The whole time I was letting him know I was his brother. I ended up having to tackle him and hold him down until he calmed down and passed out. Right before the EMT's arrived, he woke up and realized something had happened, but didn't know what. He remembered who I was, but thought he was just asleep. Obviously, he was frightened.

He has been on a number of depression medicines for some time now, and over the last year, was put on wellbutrin and colonipan(SP?). 6 days prior to the seizure, he said he had suddenly stopped taking the colonipan.

The dr's believe it was the wellbutrin or the colonipan, and pulled him off both. But his Psychiatrist told him to get back on the colonipan(sp?) but to stay off the wellbutrin.

Number one, Has any one exhibited this srt of confusion/rage when having a seizure, and could it be from one of these two drugs?

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Number one, Has any one exhibited this srt of confusion/rage when having a seizure, and could it be from one of these two drugs?

Personally, no. Apparantly, according to witnessess, I'm a mellow seizurerer. But some people can exhibit signs of agression during a seizure or in the post-ictal stage--that's why it's important to just leave them alone during their seizure, unless they're about to cause bodily harm to themselves--like walk into traffic. In my case, I try to walk off the deck and go swimming in the lake and my husband gently guides me back into the house. He says I swat his hand away, but I'm not violent about it or anything.

The stopping breathing thing during a tonic-clonic is very common. We always start breathing again once it's over, rest assured. If not, that's when you start CPR. If the seizure lasts more than 5 minutes or another follows the first seizure, then you call 9-1-1.

The key is to just let the person having a seizure "ride it out." Once the seizure is done, and he/she awakens, talk to the person in a calm, gentle tone. The person who just had the seizure will be very confused and literally, not in his "right mind." Not all of the neurons have rebooted yet and he is acting purely on auto-pilot.

Whether or not your brother seized because he was on a combo of Wellbutrin and Clonopin...who knows. I guess his doctor took him off of the Wellbutrin because Clonopin is kind of the lesser of two evils, so to speak. It's not as powerful and lots of people who have seizure disorders take it as it doesn't lower the seizure threshold as much as Wellbutrin.

I hope your brother is doing better.

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Whether or not your brother seized because he was on a combo of Wellbutrin and Clonopin...who knows. I guess his doctor took him off of the Wellbutrin because Clonopin is kind of the lesser of two evils, so to speak. It's not as powerful and lots of people who have seizure disorders take it as it doesn't lower the seizure threshold as much as Wellbutrin.

Actually, Klonopin doesn't lower the seizure threshold at all; it raises it. Pretty much all benzos are at least mild anticonvulsants, and Klonopin is one of the ones that's the most effective as one. For most people, it prevents seizures. However, that also means that stopping it suddenly instead of slowly decreasing it can cause seizures, so if he did indeed do that a few days before it happened, that could be what was responsible, especially if he had been taking a moderately large dose on a daily basis before that. This is why unless a medication is doing something truly horrible to you, it's almost always best to taper off it slowly to let your brain/body readjust, just in case. Unfortunately, he got to learn that the hard way. On the plus side, if that was the cause of it and he hasn't had it happen before, it's possible that it could just be a one time thing because of the sudden discontinuation of the med, and as long as he doesn't do that again, it might not happen ever again.

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He has been on a number of depression medicines for some time now, and over the last year, was put on wellbutrin and colonipan(SP?). 6 days prior to the seizure, he said he had suddenly stopped taking the colonipan.

The dr's believe it was the wellbutrin or the colonipan, and pulled him off both. But his Psychiatrist told him to get back on the colonipan(sp?) but to stay off the wellbutrin.

Klonopin - it seems to be one of the more popular anxiolytics/anticonvulsants to prescribe along with Wellbutrin. The psychiatrist was correct to put your brother back on it at least until he can see a neurologist (to make sure there's no likelihood of a repeat)

Number one, Has any one exhibited this srt of confusion/rage when having a seizure, and could it be from one of these two drugs?

Not all seizures involve a loss of consciousness and/or a lot of flopping around A complex partial seizure can look like confusion/rage/bizarre behavior to an observer. Unfortunately for the person involved, it is possible for Wellbutrin to cause complex partial seizures. With temporal lobe involvement, that can be extremely unsettling.

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Guest_NH Guest_*:

It's much more common to go from a partial seizure (simple or complex) to generalized than vice versa.

I've done some strange things during a CP, mostly wandering around and not answering people.

Afterwards I usually have anxiety type feeling and tired.

During a Jacksonian recently I kept saying "HI!".

I often repeat the same sound (k or ok) during absences.

But nothing like what you described about your brother.

sorry.

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Has anyone had anything similar occur to them?

My brother (21 yrs old) had his first tonic-clonic seizure two nights ago while he, my mother, and my wife and I were having dinner. It was the scariest thing I have ever been through, and fortunately he remembers nothing from it. It lasted 3 to 4 minutes, and he stopped breathing. I had to give him a quick steady tap on his back and he began inhaling again. Suddenly, he came to, and stared at me as if he didn't know me and started screaming. He charged me and tried to throw a chair, and continued to scream. The whole time I was letting him know I was his brother. I ended up having to tackle him and hold him down until he calmed down and passed out. Right before the EMT's arrived, he woke up and realized something had happened, but didn't know what. He remembered who I was, but thought he was just asleep. Obviously, he was frightened.

He has been on a number of depression medicines for some time now, and over the last year, was put on wellbutrin and colonipan(SP?). 6 days prior to the seizure, he said he had suddenly stopped taking the colonipan.

The dr's believe it was the wellbutrin or the colonipan, and pulled him off both. But his Psychiatrist told him to get back on the colonipan(sp?) but to stay off the wellbutrin.

Number one, Has any one exhibited this srt of confusion/rage when having a seizure, and could it be from one of these two drugs?

had one almost exactly as you described. i had no idea who i was or who the president was or what town i lived in when i came to (coincidentally, just after the emts arrived. i was aware *sort of* before that, but couldn't process what anyone was saying to me and just thoroughly not *there*) from what i'm told, i seized for about 5 minutes. i was absolutely confused and post-ictal out of my head after that for a few days. and it took me a few months to get all my meds worked out and my neurology business sorted out. thankfully, have a good neuro and a great shrink. unfortunately, it freaked me way the fuck out and i was just ... out of sorts for a while. i've adjusted. haven't had another t-c since then, largely limited to simple partials.

eh, but yeah. i had post ictal anger ... just a scary gamut of emotions from here to mars for a while.

GLAD that's sorted out. and my best to your brother. wellbutrin xl 450mg was my killer trigger. and previously had no evidence of seizure disorder.

i stopped the wellbutrin (even though i rather liked the med and it worked for me until i seized like a rusty engine). started lamictal and have clonazepam around for sleep, suspected seizure auras etc. the general concensus is that i was having seizure activity before the big bang, but that it went unrecognized since it was never on my radar.

confirmation from big bossman puts him worried about me in the 2-3 months prior to my episode ... having cognitive difficulties - which was especially disturbing to him since i'm his editor/copy writer/ reminder of all things important.

ah. hope that info helps? not sure how it might, but again ... cheers and best of luck

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  • 1 month later...

I just had a sezure last thursday. It lasted 15 minutes and i was chocking on my own spit when my bf and dad found me. I have been geting lots of testing done in the last few days and have found nothing the only thing the docs think it is, is the wellbutrin! I have a lot of mixed thoughts about this because I was doing very well then this happend. and I really cant explane to anyone the feeling and pain in my head/body I have had seince then. If any one els has had one that wants to give me some advice It would be greatly app.! Thanks~ Jaclyn ;)

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I was doing very well then this happend. and I really cant explane to anyone the feeling and pain in my head/body I have had seince then.

Depending on which parts of the brain took the brunt of the seizure activity, there may not *be* words for how you feel. Complex partial seizures are just screwed up like that.

If any one else has had one that wants to give me some advice It would be greatly app.! Thanks~ Jaclyn ;)

Luckily, if the seizures were induced by Wellbutrin, once you stop it they won't come back. If you've had seizure "auras" for a long time, those might take a while to completely go away.

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  • 6 months later...
Guest Guest

I had my first seizure in 2006 from Wellburtin. I know I was not maxed out at the full strength and was not aware I was having seizures. I was in town visiting and stopped at a grocery store where I was arrested for suspicion of DUI. There was an "eye witness" taht reported I hit a building in the the parking lot (the building in question was across from where I was parked). I was surrounded by a circus, had no idea what was going on as I recalled nothing. My moms car was impounded, I of course failed the roadside sobriety test, the fire department indicated I had a low BP and I was arrested. A special police officer came to the station after I blew a 0.0 and gave me a glorified field sobriety. Her impression was that I was under the influence of some type of drug. Apparently my puppils were not reacting the way they were supposed to. They then transfered me to a hospital to have my blood drawn. Subsequently, the state charged me with a DUI for Wellbutrin. They ended up lowering the charge to a "Hit and run unattended" which I now regret pleaing no contest to. I did not have access to the witness report until after the case was done. In-between this time I started ahving seizures (6 total) and never recall anything. Soemone (usually the paramedics) have to relay that I have had one and it would take several hours for me to get back to normal. All tests neurologically were fine and I d/c the drug, however, have had two seizures post the Wellbutrin more than a year ago (now seizure free). The eye witness report indicated I rolled down my window and could not form words when he was asking if I was ok..... Needless to say it all made sense after the incredible stress, huge fni strain as I was not coverd with medical insurance, and the psyc affects due to the chaos and lasting issues surrounding the accident..

This is a dangerous drug and had I been on the hwy I most likely would not be here. With that said, my neuro tests weer all normal and it would have probably been indicated the accident was due to my driving or the conditions/cell use.... Who knows.

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  • 3 months later...

My girlfriend was put on Wellbutrin in early July at 150 mg a day. Then it was upped by the shrink to 300 mg a day in late August. A week later she had a seizure for 5 minutes and stopped breathing. She wound up in the emergency room for 6 hours and the hospital for 24. All the tests (EEG, MRI, catscan, etc.) were negative. The shrink also had her on some sleep aid (can't remember which) because the Wellbutrin apparently can also cause insomnia. Though the sleep aid just made her sleepy but didn't let her get into natural REM sleep (according to Neuro docs at hospital). IMO the shrink set her up for failure and if I ever meet him he is getting a punch in the face.

The Neuro doctors blamed the seizure on the Wellbutrin and lack of sleep. They recommended that nobody take this crap and subtly hinted that shrinks are f-ing people up. She has been off the sleep aids and has been sleeping great the last few days. .She has been weening herself off the Wellbutrin for the last week and today is the last day. She is nervous that her depression will be bad (though from what I have noticed it is actually quite mild), but she is actually a very cheerful person that I belive got a lot of bad advice.

My mom has been a nurse for 30 years and she mentioned that she has seen more seizures in young people (teens to late 30s) in the past 12 years then ever before. Most of it caused by Wellbutrin like anti-depressents.

just thought I'd share.

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There are many of us here who have taken WB for years with great success and no seizures. I've been on it for (I think) 3 years and love it. I'm very sorry about what happened to your girlfriend, but I don't see why her unfortunate experience should stop other people from taking a very effective antidepressant.

When you have some statistical proof of the "danger" of taking Wellbutrin, instead of an anecdote, please come back and put up the numbers.

olga

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IMO the shrink set her up for failure and if I ever meet him he is getting a punch in the face.

In most jurisdictions that's called "assault"

The Neuro doctors blamed the seizure on the Wellbutrin and lack of sleep. They recommended that nobody take this crap and subtly hinted that shrinks are f-ing people up.

If you and the "neuro doctors" think *that's* fucked up, you should see what a suicide looks like.

She has been off the sleep aids and has been sleeping great the last few days. .She has been weening herself off the Wellbutrin for the last week and today is the last day. She is nervous that her depression will be bad (though from what I have noticed it is actually quite mild), but she is actually a very cheerful person that I belive got a lot of bad advice.

Like the advice that she's getting from you: pretend to be cheerful and learn to stop talking about feeling depressed if she wants to keep you around.

Now that you've given your professional opinion, as an officially sane person to the local nutcases, about how we're all going to have seizures of biblical proportions, dogs and cats living together in sin, etcetera, etcetera, etcetera, feel free to bugger on off. It's a known risk to anyone who's bothered to read the patient information sheet that comes with the drug.

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When you have some statistical proof of the "danger" of taking Wellbutrin, instead of an anecdote, please come back and put up the numbers.

I'll save him the trouble. Here's the scary statistical proof.

Short version: The risk of seizures while taking Wellbutrin is dose-dependent. It's as high as 2.2% when taking more than 450 mg/day, but at lower doses it drops dramatically to 0.4%, and it's even lower with the extended-release version. That compares to 0.2% for most SSRIs, and just under 0.1% for the general population. Not surprisingly, this is why approximately no one takes more than 450 mg/day of Wellbutrin and also why most people not taking superhuman amounts of it (i.e. over 450) don't have their brains melt and ooze out their ears.

I hate the stuff, too, because I was one of the lucky winners whose brain did melt and ooze out their ears from taking it, but might as well at least be realistic when complaining about it.

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  • 3 weeks later...

For no apparent reason, I took an extra 150mg for a ttl of 450mg. Dr. and I believe this led to my first seizure the other day. I've had so much success with the WB that we decided I'd stay on it but also take Lamictal. Bottom line, never suddenly alter your Wellburtin dose.

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  • 2 weeks later...
Guest guest-guest

For no apparent reason, I took an extra 150mg for a ttl of 450mg. Dr. and I believe this led to my first seizure the other day. I've had so much success with the WB that we decided I'd stay on it but also take Lamictal. Bottom line, never suddenly alter your Wellburtin dose.

i had just started WB several weeks ago. i was on 150 a day for 7 days. then 300 a day thereafter. two weeks after i started the 300 mg daily dose i had a seizure at a office depot in the mid-afternoon. i woke up with no recollection of anything in the local ER with an IV and tons of tubes and electrodes on my body around 8 hours later. i stopped taking the WB that day. two days later was my usual P-Doc med check appt. and he put me on lamictal and xanax for the panic attacks after the seizure (everytime i get a slight headache or tinge,i think a seizure is coming).

before this incident i had no seizure history; although i'm a grad student running between labs a lot on campus so its possible i could have had pre-seizure activity after the WB started and just didn't recognize the behavior (who knows?). the WB was working so i'm looking for a new AD with the same effects. or maybe a combo of the WB at a lower dose and the lamictal? in the meanwhile i'm going to start playing the lottery since my chances were so great on the WB

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  • 4 weeks later...

I just don't buy the stats. I know waaaay too many people who've seized on WB. Even my doc was suspicious of the stats.

I had a seizure on 450 but want to back on the lower dose which had been working fine. wellbutrin was a godsend. at least it was incredible until I woke up in a pool of blood missing my front teeth and a chunk of my top lip.

For no apparent reason, I took an extra 150mg for a ttl of 450mg. Dr. and I believe this led to my first seizure the other day. I've had so much success with the WB that we decided I'd stay on it but also take Lamictal. Bottom line, never suddenly alter your Wellburtin dose.

i had just started WB several weeks ago. i was on 150 a day for 7 days. then 300 a day thereafter. two weeks after i started the 300 mg daily dose i had a seizure at a office depot in the mid-afternoon. i woke up with no recollection of anything in the local ER with an IV and tons of tubes and electrodes on my body around 8 hours later. i stopped taking the WB that day. two days later was my usual P-Doc med check appt. and he put me on lamictal and xanax for the panic attacks after the seizure (everytime i get a slight headache or tinge,i think a seizure is coming).

before this incident i had no seizure history; although i'm a grad student running between labs a lot on campus so its possible i could have had pre-seizure activity after the WB started and just didn't recognize the behavior (who knows?). the WB was working so i'm looking for a new AD with the same effects. or maybe a combo of the WB at a lower dose and the lamictal? in the meanwhile i'm going to start playing the lottery since my chances were so great on the WB

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I just don't buy the stats. I know waaaay too many people who've seized on WB. Even my doc was suspicious of the stats.

I'm not going to pretend that the numbers given are completely infallible and can't possibly be wrong, but they don't just pull them out of their ass. It's a very commonly used medication, and an enormous number of people take it with no problems. They do actually do studies and track adverse reactions to come up with the numbers they list. 2.2%, or whatever the number is at 450 mg/day, is a pretty high number if you think about it and put it in perspective.

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If I am reading this correctly, his brother had abruptly stopped taking klonopin and had a seizure... yet the doctor says to stay on the klonopin and d/c the wellbutrin? Huh? It is possible he had a seizure because of klonopin withdrawal. D/cing wellbutrin is totally unnecessary (especially if it was helping) and the brother should be instructed not to abruptly change the frequency with which he takes benzos. Withdrawal from benzos is notorious to cause seizure. Wellbutrin is only an aggrivating factor.

How much klonopin, for how long was he taking it? Because abruptly stopping it can certainly cause a seizure.

Psychiatrist sounds like an idiot. Taking away a depression med that might be helping because the patient abruptly d/ced his benzos is just stupid and mindless. It's like d/cing wellbutrin in a patient who goes into seizures secondary to abruptly stopping alcohol after drinking a 6 pack/day or more for years. It just reeks of not thinking and not caring. Explain to the patient that abruptly discontinuing any medication especially a benzodiazepine is dangerous and can cause seizures.

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  • 10 months later...
Guest ilovepersiancats

I agree, I was on Wellburtin too. It caused me to have the seizure of my life, what a whopper.I ended up in the hospital, with left sided brain damage. I am now on Keppra (generic of course) the insurance company is too cheap to pay for the name brand.

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Guest ilovepersiancats

Wellbutrin sucks! It caused me to have a horrific seizure and had to be hospitalized. The left side of my brain was damaged, and it didn't even help with the depression anyway! That drug needs to be taken off the market!

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I had a series of seizures a year-and-a-half ago. I was on Lithium, Geodon, Provigil. Atenolol and Wellbutrin. The Neurologist feels strongly that it was the Wellbutrin (400 mg). Does anyone else have any thoughts? (Have been on Keppra to counteract the seizures since then but he wants to stop it.)

I also have a friend who had seizures on Wellbutrin. Never had one before in his life. He already had tics though. Irresponsible doctor IMO.

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  • 5 months later...

I'm curious, did you go back on a low dose of Wellbutrin? Did it work out for you?

I had the same thing happen after my doc upped the dosage even though I was doing fine on 200mg/day. Went up to 400 and had a massive seizure. Just had a root canal from the shattered tooth (this is 7 years later).

As sick as it is though, I want to try it again. I'm willing to give up driving and working with children while I try to go back on a low dosage.

I was never so happy, calm and over all well as I was when I was on Wellbutrin (except for a violent 10 minutes which i don't recall)

Would love to hear how you're doing.

Thanks!

I'm new here, and although it seems that people haven't posted in this thread for awhile, this is exactly the discussion I was looking for. I actually did have a seizure a couple years ago right after my doctor increased my dosage of Wellbutrin (I had been against increasing it, because I felt fine...but my doctor insisted on giving me more). Of course, I had a seizure. I stopped taking the Wellbutrin immediately and never had a seizure again.

As for the med history, after I went off the Wellbutrin, I didn't take any seizure meds for 4 months. I didn't think I needed it. After those months my neurologist still suggested I go on seizure meds...so I went on Keppra. I've been on 250mg twice a day for about 8 months, and the past 2 months I've only taken the 250mg once a day. Now, I know Keppra is usually a supplement to another seizure med...and I also know that 250mg seems to be a dose that is too low to really make a difference...but either way I've been seizure free.

What I want now is to go back on the Wellbutrin XL at the lowest dosage. I've been depressed for a very long time and Wellbutrin made me feel normal and good again. What I'm wondering is if I should take the 250mg Keppra once a day when I start the Wellbutrin? I've been tapering off the Keppra because I haven't had seizures..but if I start Wellbutrin again should I keep taking it? I'm thinking that the less medication in your system, the better....but I'm not sure in this case. Are there any complications with taking Keppra and Wellbutrin at the same time?

Thank you sooooooooo much!

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  • 2 years later...

I had the same experience.  I have a history of epilepsy, but after 20 years without a grand mal seizure, just not something I thought about every day.  So this quack NP (not even a doctor) writes me a script for Buproprion, without asking about seizures.  I seized about 5 minutes after coming off the road (it's an hour drive into town).  Needless to say, she pleaded innocent.

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Since this post has been resurrected I will add that i have been on 300mg of wellbutrin for 6 years. My doc tried to switch it to something else but I wanted my wb back. Added energy. No libido issues. Cut down on smoking. Btw i no longer smoke :). Dh has been prescribed wb to help him quit smoking. First time he quit for three years. Second time for 8 months. Both times he had such an increase in energy he had to run for bout 35-45min every night. Both times he started smoking again was becauze of major life stressors.

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