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My Psychiatrist created a "Triple Reuptake Inhibitor"

Freddy
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Freddy

Freddy

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My psychiatrist has me on a powerful combo for depression and augmenting it with lithium, Abilify, and thyroxine. 

Ive tried practically every drug for depression and only some combos worked for me. I have severe depression/treatment resistant depression, bi polar ADHD and PTSD. After trying so many combos this one actually lifted me out of the depression! I'm a new paraplegic and struggling everyday after I jumped from a building 5 floors up. I've been hospitalized for 8 months and have been given a 2nd chance. 

I tried all the ssri and the new drugs that are on the market in various combos but never found something that worked. My psychiatrist said if this combo fails that I'm a good candidate for ECT as my depression was the melancholic when a tricyclic TCA is appropriate. A kind of depression where there's no energy at all. All I did was sleep and cry and think about suicide/acting on it especially now that I'm paraplegic and require care aides to just go to the bathroom. Even when people speak to you it sounds slow and thinking is slow. A very dark place to be. Nothing worked except this combo and augmentors.

The core of the meds for depression is a "triple reuptake inhibitor" or SNDRI:

 

Nortriptyline 150mg at night SNRI

Bupropion 300mg in the morning. NDRI

methylphenidate 40mg SR (2x 20mg SR) in the morning DNRI.

 

The core 3 drugs are augmented with:

lithium 1050 at bedtime

thyroxine 100mcg in the morning

abilify 5 mg in the morning

 

(also on diazepam, gabapentin, nabilone and Hydromorph Contin)

 

Lithium with nortriptyline in itself is very powerful enough for severe depression. This didn't work so all these meds were added to the regime and work synergistically to create a powerful augmented SNDRI. The psychiatrist said it would be similar to cocaine but lasts a lot longer. I've done cocaine 5 times in my life and was a very powerful experience that resulted in me shouting and very angery at everyone/everything for about an hour so I was a little weary. I can say this when the nortriptyline kicks in it's a very euphoric simular to coke but without the anger. I'm so happy I'm smiling/grinning all the time making my face ache and all squinty-eyed. I love getting up in the morning now and whizzing through the day until the methylphenidate wears off around 6pm then I start to wind down but miraculously can sleep cause the nortriptyline makes you drowsy. Then the cycle starts all over again. I know lots of meds are not good but sometimes necessary! My next goal is to go off diazepam once I get used to this powerful combo. It's a little too stimulating and causes a little anxiety at first until you get used to it. At least I avoided having ECT done. That would be last resort.

I hope this info helps someone else 

 

 

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Wooster

Wooster

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I'm not sure how you can tell when the nortriptyline "kicks in" as the half life is 28-30 hours and you're taking it daily at bed.

Glad you've found a combo that seems helpful though.

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Freddy

Freddy

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5 minutes ago, Wooster said:

I'm not sure how you can tell when the nortriptyline "kicks in" as the half life is 28-30 hours and you're taking it daily at bed.

Glad you've found a combo that seems helpful though.

It kicked in 10 days after taking it at bedtime

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Freddy

Freddy

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4 minutes ago, TakeAChillPill said:

I'm glad you found the strength to carry on with the help of some medications.  :-)

Thanks. It hasn't been easy I'm still adjusting to life in a chair. The meds have been a god send.

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Southern Discomfort

Southern Discomfort

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I'm glad you've found a combination that works for you, no one deserves to be depressed.

In Stephen Fry's documentary, 'The Not So Secret Life of The Manic Depressive' it featured a woman who jumped out of a window believing she could fly. She ended up in a wheelchair too. Really good watch, I think it's on YouTube. 

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Butterflykisses

Butterflykisses

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I am SO sorry the absolutely horrific realities of depression caused your life to be forever changed. I have the utmost respect for you. I am so glad you are fighting this demon and have found medication useful. I hope things continue to go upward for you, as you deserve it! Please keep us posted!

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y1gFwo

y1gFwo

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that's wonderful. i understand the need to avoid ECT, i'm severely depressed and anxious now. i'm glad your psychiatrist could work with you to help lift you out of that depression.

Edited by y1gFwo
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melissaw72

melissaw72

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14 hours ago, Southern Discomfort said:

I'm glad you've found a combination that works for you, no one deserves to be depressed.

In Stephen Fry's documentary, 'The Not So Secret Life of The Manic Depressive' it featured a woman who jumped out of a window believing she could fly. She ended up in a wheelchair too. Really good watch, I think it's on YouTube. 

I agree that it was very good.  (I am not endorsing the believing she could fly was a good thing, but the videos tell a bigger story).

It is in 2 parts, shown below:

Part 1:

 

Part 2:

 

 

I'm really glad your meds are helping you!

Edited by melissaw72
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melissaw72

melissaw72

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1 hour ago, Southern Discomfort said:

That's actually the first one he did about ten years ago. The second one, The Not So Secret Life of the Manic Depressive should be up there too, it came out this year during the BBC's All In The Mind season.

I looked up the youtube video of "the not so secret life ..."  and all it had were 2 small clips from the documentary.  If you can find the youtube videos of the documentary you are referring to, will you please post?

52 minutes ago, Hopelessly Broken said:

https://m.youtube.com/watch?v=uj8hqXd7N_A Part 1

https://m.youtube.com/watch?v=B3rHTm1YLxA Part 2

I think he is quite the man, myself, despite not having bipolar. 

Are these the same as the videos I posted above, or different ones?  I wasn't sure when I clicked on them.

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melissaw72

melissaw72

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20 minutes ago, Hopelessly Broken said:

https://m.youtube.com/watch?v=FsD3xT-RL-k 

This is the one I meant. Its just one, but different. I apologise, my phone is an idiot and sometimes the keyboard plays up on me. 

No apology needed ... it happens.

Thanks for the link!  I couldn't find it this morning when I looked for it.

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Freddy

Freddy

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3 hours ago, Southern Discomfort said:

Here it is.

Thanks for posted the documentary. I saw both movies and was impressed. It's nothing I didn't know already but definitely solidified things for me. It put a little fear in me though but the healthy kind. I must always take my lithium everyday and the rest of my meds too. I'm going to watch the finale 3rd movie today. 

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