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anti-convulsants and cognitive side effects


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i know this is a regular question asked, but i wanted to ask it anyways.....

for each one of you, what anti-convulsant seems to have the less side-effect on cognitive functioning.  Right now i'm on Gabitril at a very low dose, and when i take the Gab i just become so so minimized cognitively.  Thus, i cant take it during the day (after about 8-9 hrs of it wearing the cognitive side effects diminish, though i cant just take this at night time.....for i'm having anxiety reactions during the day because the half-life runs out on me...so i'm lookin for somethin that i can possibly take during the day, or possibly take at night and not have the half-life issue occur).

thanks

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I've only been on 3 - Topamax, Lamictal and Lyrica.  The least cognitive side effects would have to be Lamictal and Lyrica (although I'm only on a small dose right now).  Topamax made me dumb as a rock.  I could not finish a complete sentence.

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thanks all, i did some diggin through the search function and found a study posted by another c-board'r.....which stated that through a study of around 159 people, the anti-convulsants that had the least cognitive effect on the individuals in the study were in this order: (1) Lamictal, (2) Trileptal, (3) Lithium, (4) Topomax, (5) Depakote, and (6) Tegretol........ I am in the mind to try Lyrica, though i dont know if my p-doc can prescribe it to me...i havent asked her about it yet, but what i saw from FDA approval letters, Lyrica had not yet been approved for the treatment of anxiety disorders......though i wonder if my RLS would fall under the disorders that it is approved for....anyone have a clue to what the deal is with being able to prescribe such a med? do you have to have a specific disorder to get it prescribed for you?  If not Lyrica then i may try smaller doses of Neurontin or Trileptal and see if i can get by...

thanks all....

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After the first few months I actually did really well cognitively on depakote.  After 5 years it screwed up my hormones, so I had to switch.  Lamictal is marvellous for my cognitive functioning; even though I'm still having some minor depression my head is incredibly clear. 

I'd just caution you to remember that YMMV.  If I remember right, what that study ranks is not how the med affects everyone who takes it; it's about the likelihood of having cognitive problems on that med.  Some people do great on depakote or lithium; some are all blurry and flat on lamictal.  You won't know how you react to a med until you give it a full trial, which means dealing with any initial side effects and seeing how you come out the other side.

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thanks all, i did some diggin through the search function and found a study posted by another c-board'r.....which stated that through a study of around 159 people, the anti-convulsants that had the least cognitive effect on the individuals in the study were in this order: (1) Lamictal, (2) Trileptal, (3) Lithium, (4) Topomax, (5) Depakote, and (6) Tegretol........ I am in the mind to try Lyrica, though i dont know if my p-doc can prescribe it to me...i havent asked her about it yet, but what i saw from FDA approval letters, Lyrica had not yet been approved for the treatment of anxiety disorders......though i wonder if my RLS would fall under the disorders that it is approved for....anyone have a clue to what the deal is with being able to prescribe such a med? do you have to have a specific disorder to get it prescribed for you?  If not Lyrica then i may try smaller doses of Neurontin or Trileptal and see if i can get by...

thanks all....

<{POST_SNAPBACK}>

I am being prescribed Lyrica off-label for migraines by my neuro.  My pdoc knows that I am taking it and has heard of it but hasn't prescribed it to any one, so he is curious as to how I will do on it too (I feel like a guniea pig).  I have experienced a little decrease in anxiety.

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Hi!

I've only been on Tegretol Retard (the European extended release) and Trileptal Retard, and have to say that the latter is the best one seen from a cognitive point of view. Unfortunately it stopped working for me after six months or so, so now I'm back on Tegretol Retard. I prefer foggy over black and blue from seizures... ;)

H.

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