browri Posted October 26, 2016 Share Posted October 26, 2016 Good Afternoon everyone! I posted this in another forum, but I wanted to get a gauge of how people do when using Wellbutrin with an antipsychotic. I'm currently taking: 900mg Trileptal (300mg 3x/day) 200mg Lamictal (100mg 2x/day) 174mg Aplenzin (eq. 150mg Wellbutrin XL) 40mg Latuda Despite the fact that I'm now taking 4 medications to control rapid-cycling BPII, I'm actually really happy with where I'm at with my cocktail. I actually feel like each one serves its purpose. Latuda is the main bipolar antidepressant, but it is augmented with Aplenzin and Trileptal. Trileptal helps to keep me calm. Aplenzin helps with motivation, energy, pleasure, sex drive. Lamictal helps calm the waves. And in the time that I've been on Lamictal, my mood episodes have been much shorter. Previously they would debilitate me for days, but now they're more short-lived. And the Latuda is like a light-switch. I just transitioned back to it after being on other medications for the past year and it has been SO nice. The main reason I'm posting this though really is to get an idea of how people on Wellbutrin do with an antipsychotic. Things are more than they seem I'm sure, but one would think that they would fight each other. Wellbutrin inhibits norepinephrine and dopamine reuptake thus increasing levels of said neurotransmitters in the synapse. Antipsychotics work to BLOCK dopamine receptors and many of them noradrenergic receptors as well, but this inherently causes upregulation of both neurotransmitters as well. Anyone out there have Wellbutrin combined with an AP and/or other meds? Link to comment Share on other sites More sharing options...
crtclms Posted November 14, 2016 Share Posted November 14, 2016 I was on Wellbutrin/buproprion and Latuda for maybe 8 or 9 months? I did extremely well on it, but Latuda is so expensive, I couldn't get it anymore. I'm still on Wellbutrin. With a 6 month gap, I've been on buproprion for over 20 years, and it hasn't interfered with any of my other medications. Link to comment Share on other sites More sharing options...
Mister Joshua Posted November 17, 2016 Share Posted November 17, 2016 I am on Geodon (ziprasidon) and Wellbutrin, plus lithium, strattera, transform and vistaril (hydroxyzine). I have been taking Geodon and Wellbutrin together for about 3 years. I have had no problems other than the Geodon pooping out and/or my BP 1 getting worse. I am now in the process of switching to Latuda. Link to comment Share on other sites More sharing options...
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