KSL Posted January 6, 2017 Share Posted January 6, 2017 I've been on 80mg Latuda for 4yrs at pm along with qty2 vistaril 50mg and qty1 50mg Topomax. I take 20mg fluoxetine and 200mg SR Wellbutrin am as well. I found out early on that I can take the topomax and vistaril with dinner or shortly after but not the Latuda. It makes me feel super agitated, uncomfortable like I'm crawling out of my skin. But if I wait and take it at bed, I just go to sleep and no issues. So I started that in 2012 and have been stable bipolar2 since. I don't recall the thing about having to eat. And no one has asked. Well just the last month I've gone slightly manic and so today we decided to go up to 120mg Latuda and so I got on here just seeing if anyone had any issues increasing dosages and I see all these posts about food. I've NEVER in 4 years eaten with my Latuda. I just take it and go to bed. It's worked for 4yrs. Guessing I shouldn't start now. Just go up in dose and keep doing what I'm doing? Thoughts? Link to comment Share on other sites More sharing options...
CrazyRedhead Posted January 6, 2017 Share Posted January 6, 2017 (edited) Latuda is really supposed to be taken with food, at least 350 calories. If taken without food, only 30-50% of the medication will be absorbed: http://www.moodtreatmentcenter.com/lurasidone.pdf Edited January 6, 2017 by CrazyRedhead Link to comment Share on other sites More sharing options...
KSL Posted January 6, 2017 Author Share Posted January 6, 2017 Thanks. I see that it is supposed to. But my question is, for four years Ihaven't. Should I all of a sudden start to, and increase my dose? Or just continue taking without food like I have been. Link to comment Share on other sites More sharing options...
mikl_pls Posted January 6, 2017 Share Posted January 6, 2017 It could be that without you eating along with it, it may not be fully effective, thereby requiring you to raise your dose all this time, especially recently to 120 mg. If you were to suddenly start eating with 120 mg, it could be that you suddenly start absorbing it more efficiently and thereby raise your effective dose in your body and it could be too strong for you, needed you to back down to 80 mg or even 60 mg. That's just my guess on the situation. Be careful if you suddenly start eating with it as it may become stronger. However, if you're recently gone into a manic state, it could be just what you need. One thing to note is that Latuda isn't FDA approved for manic episodes, only bipolar depressive episodes, so it may be questionable as to its efficacy as an anti-manic. 1 Link to comment Share on other sites More sharing options...
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