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3 hours ago, orangey123 said:

I have an odd question 

I had to take motrin at a High dose for a week. I started having nightmares anxiety and insomnia. I told my doctor and they don't care. I take klonopin daily

I saw that klonopin and motrin are metabolized by the same cytochrome. Am I correct? Would this lower one? 

Thanks!!!

I don't know about drug metabolism, however, if you look at the Drugs.com site, it does mention many side effects of Ibuprofen (Motrin) & that it can cause nervousness (common), depression & sleeplessness (rare): https://www.drugs.com/sfx/ibuprofen-side-effects.html

I also came across an article that talks about how many painkillers/NSAIDs can reduce the effectiveness of SSRI's: http://healthland.time.com/2011/04/25/how-advil-thwarts-the-effects-of-prozac/

This research discusses only Serotonin-drugs, I have not read that this interaction occurs with Klonopin or other benzos, but maybe that is a possibility?

 

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Does this help?

(it compares ibuprofen, but that is pretty much the same thing as Motrin). 

https://www.drugs.com/drug-interactions/clonazepam-with-ibuprofen-pmr-703-0-1310-2584.html

Quote

There were no interactions found in our database between clonazepam and Ibuprofen PMR

 

One is a generic (ibuprofen) one and the Motrin is a brand name.

https://www.drugs.com/answers/ibuprofen-motrin-883912.html

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