Are these, too many anti-psychotics?

[battlewarrior]

Are these too many anti-psychotics? (schizoaffective bp)

Xeplion 100mg (Invega injection), Seroquel 200 SR, Olanzapine 10mg?

Plus Depakine 3xDay 500mg and Diazepam 10mg SOS

?

 

[tryp]

Nobody here is going to be able to tell you that - what you need in terms of medication is something that has to be worked out with your doctor.  It depends on your history, your symptoms, and what else you've tried.

If you're worried, talk to your doctor.

[Iceberg]

If your functionally normally and it's working maybe that combo is what u need

[notloki]

Is it working ? That's what counts.

At 200 mg Seroquel has little effect on dopamine so I really would not call it a AP until you get above 300 mg.

[Iceberg]

@notloki

haha wow pulling out the pharmaco technicality 

[notloki]

1 hour ago, Iceberg said:

@notloki

haha wow pulling out the pharmaco technicality 

 

Well it is a common fact in pharmacology that some meds do not have potent activity in general at some sites so taking a low dose just magnifies this and can allow other effects from other sites to be become apparent. Seroquel is a good example. It has moderate to weak ability as a D2 blocker. Many use it as a sleeping aid, this is because it is a strong antihistamine (sedating) and at low doses it does not block enough D2 to cause issues or side effects associated with dopamine blockade. A similar situation exists with Abilify, an antidepressant augmenter at lower doses due to its many actions with serotonin sites, with the dopamine blocking effects becoming apparent at higher doses. 

[Iceberg]

yes but I consider abilify a bit different cuz its a D2 partial agonist, as opposed to Seroquel which is just weak at D2

[notloki]

But still it is another example of an AP that is used as one thing at a lower dose and another at a hiigher one.

[Iceberg]

this is true...there are a few others too

[notloki]

I agree that abilify is a unique case where it is not how weakly it binds but that it is an agonist at D2.

[Iceberg]

Well this seems to be the new trend- the partial agonists...rexulti and than Vraylar (although that's D3 but) 

Although Vraylar isn't approved for depression w/ ad like the other two are 

[jt07]

3 hours ago, Iceberg said:

Well this seems to be the new trend- the partial agonists...rexulti and than Vraylar (although that's D3 but) 

Although Vraylar isn't approved for depression w/ ad like the other two are 

I like this new trend. It's tapping into a whole new mechanism to treat depression. I know Abilify has made a HUGE difference in my depression and motivation.

[Iceberg]

Some people say "same old same old"...(read in some article)...but it's not like the other second gens help depressive swings. Vraylar might even help negative systems of schizophrenia...if only they could figure out how to stop the akathisia/ EPS. I had akathisia horrible on abilify and now kinda on Vraylar 

Vraylar thing was in an article and my doc said it too...I hope they go for approval with that

[Always Unstable]

I think that if you feel good on what you're taking then that is the main thing. I take a lot of meds too. Two of which are antipsychotics and right now I wouldn't change a thing.

[La La LOLocaust]

I was a little bit wondering the same thing since I recently was put on a 2nd AAP. But the reality is that if you're functioning and your symptoms are under control you're probably in the right place. What I mean by that is, you should trust your pdoc's call as long as you're doing well. That's what really matters, after all.