Jump to content
CrazyBoards.org

Could Mirtazapine/Remeron be causing these weird symptoms?


Recommended Posts

I'm having a hell of a hard time and experiencing rather weird symptoms. Whether they've anything to do with Mirtazapine (Remeron) is something that I strongly feel but can't quite convince any doctor of.
 
I was put on 15 mg of it in spring 2015 for depression and a severe insomnia - I hadn't slept an hour like since 25 nights back then! The benefits showed immediately within a day and surprised myself and my family. I would sleep well and be in a very happy and cheerful mood.
 
Then however, from summer 2016 I developed some strange food intolerances; caffeine, sugar, fruits containing high amounts of fructose, yoghurt, butter and so on. Eating anything of that would cause me jitteriness and insomnia. I steered clear of those foods.
 
From autumn last year though, a lot of those food intolerances have relented and it changed into intolerance towards medicines and supplements that I was on; the thyroid medicine for hypothyroidism, Vitamin D, Calcium, Vitamin E and could never again tolerate any new medicine or supplement. Symptoms resulting from these are, again, jitters, insomnia and a strange kind of feeling of being struck on the head, like I can't hear anything and the thinking becomes very unclear and blurred. Coupled with this is a weird sensation that if a medicine has any potential side-effect (even physical, such as urine retention), I get it at all costs. So I'm steering clear of the culprits here too.
 
However, avoiding the culprits doesn't end my misery, it just helps in avoiding a whole new set of symptoms, because since autumn 2016 I'm under constant brainfog anyway, have heart palpitations immediately after every meal (but worst after breakfast), have concentration and focus issues, lead a life without any hobbies, wishes or desires. Nothing excites me, nothing interests me and nothing catches my attention. Leave tasks pending for months (the most unlike me habbit), have badly lost my sense of humour. My sense of humour was something that I literally used to pride on, and friends from around the world would call me to fresh up if they were having a dull day. My mind feels numb, although it isn´t as if it´s the sedating effect of the Mirtazapine because 90% percent of the nights I don´t sleep well, and on a lot of nights I feel as if I´m asleep with an awake mind!
 
The GP who put me on it considered it to be just the effects of anxiety and depression and recommended the doubling of the dose to 30 mg. When I contested that, given that I´ve my doubts of a lot of these issues being brought upon by Mirtazapine itself, she referred me to a psychiatrist. He too strongly denies of Mirtazapine having any hand to play on it and instead thinks it´ll be best to combine it with another antidepressant for day-time.
 
He put me on Paroxetine, boom, a flood of side-effects! Then changed to Fluoxetine (Prozac) - third day on it and having weird feelings. The heart poundings are one and is in fact making me very depressed and hopeless!
Edited by Isaiah2017
Link to comment
Share on other sites

It has been suggested by someone I know that the antihistamine effect of Mirtazapine might be related to some of these issues. Is it possible? 

Also, how many antidepressants are there with antihistamine effects? Are all sedating antidepressants antihistamine as well? 

Link to comment
Share on other sites

First, I'd like to welcome you to CB! I'm glad you found us.

I have taken mirtazapine for six years and just recently went off to lose weight. Honestly, I agree with your doctors. It sounds to me like the mirtazapine is no longer working for you and that depression has returned. I never had any of those symptoms you describe except maybe a little brain fog because mirtazapine is so sedating.

I'm not sure that doubling the dose of mirtazapine is going to do much if indeed it stopped working. Maybe, but I have never found that meds that stopped working would suddenly start working again by raising the dose. I think it is good that your doctor added another antidepressant though. However, you should keep your doctor in the loop and tell him that the fluoxetine is making you more depressed. I don't know how old you are, but if you are under 25 (I believe) there is a risk of suicidal ideation with antidepressants. If you are experiencing suicidal feelings, call your doctor immediately. If you think you might hurt yourself, go to the ER.

So what I think is that it is good that you are trying a new antidepressant. I think a lot of the symptoms you describe are depressive symptoms and are likely to be the result of the mirtazapine stopping working and symptoms of your depression returning.

Link to comment
Share on other sites

On 6/11/2017 at 9:39 PM, jt07 said:

First, I'd like to welcome you to CB! I'm glad you found us.

I have taken mirtazapine for six years and just recently went off to lose weight. Honestly, I agree with your doctors. It sounds to me like the mirtazapine is no longer working for you and that depression has returned. I never had any of those symptoms you describe except maybe a little brain fog because mirtazapine is so sedating.

I'm not sure that doubling the dose of mirtazapine is going to do much if indeed it stopped working. Maybe, but I have never found that meds that stopped working would suddenly start working again by raising the dose. I think it is good that your doctor added another antidepressant though. However, you should keep your doctor in the loop and tell him that the fluoxetine is making you more depressed. I don't know how old you are, but if you are under 25 (I believe) there is a risk of suicidal ideation with antidepressants. If you are experiencing suicidal feelings, call your doctor immediately. If you think you might hurt yourself, go to the ER.

So what I think is that it is good that you are trying a new antidepressant. I think a lot of the symptoms you describe are depressive symptoms and are likely to be the result of the mirtazapine stopping working and symptoms of your depression returning.

I´m open to such ideas and suggestions of ultimately depression and anxiety triggering off such symptoms, and I went to a psychiatrist only after being convinced of it. So I don´t contest that, but my psychiatrist himself was so confused at our first appointment that he too pointed towards these being result of a possible underlying liver or heart disease, or some hormonal issue - all of which I´ve got checked and all test results came back negative. So even he isn´t sure what to make of it.

 

When I´d depression which led to Mirtazapine, the symptoms were very classical, such as insomnia, spells of extreme sadness and constantly pondering the purpose of my life etc. Now however, it´s very rarely that, it´s just that I feel numb and disinterested in anything..

 

The food, medicine and supplements intolerance that I´m experiencing, is it really something that´s associated with depression, even if in rare cases? I´m confused.... I´m 27 by the way and have stopped Fluoxetine due to the worsening of symptoms by it - at the psychiatrist´s advice. He might ask me to see him soon though.

 

My gut feeling still is that combining anything with the Mirtazapine won´t work. Switching over to another one altogether might be a better option, but switching to an antidepressant like Paroxetine or Fluoxetine isn´t a good alternative since they´re not sedating like Mirtazapine.

 

Which one are you on right now, if I may know?

Edited by Isaiah2017
Link to comment
Share on other sites

I would try to get of mirtazapine if possible (unless you already have), and if you don't tolerate fluoxetine, perhaps try citalopram or escitalopram—they have a generally high tolerability profile.

Link to comment
Share on other sites

17 hours ago, mikl_pls said:

I would try to get of mirtazapine if possible (unless you already have), and if you don't tolerate fluoxetine, perhaps try citalopram or escitalopram—they have a generally high tolerability profile.

I forgot to add here that before I was finally put on Mirtazapine, my GP tried Citalopram. It kept my wide awake the whole night and gave me inorgasmia. Was discontinued after five days.

Link to comment
Share on other sites

If it was me, I would taper off Remeron and see if any of the symptoms subside. I was on 45mg for almost 2 years and stopped it cold turkey. Had insomnia for several days, brain zaps, dizziness, but it subsided after a week.

Link to comment
Share on other sites

  • 3 weeks later...
On 6/13/2017 at 5:57 PM, dtac said:

If it was me, I would taper off Remeron and see if any of the symptoms subside. I was on 45mg for almost 2 years and stopped it cold turkey. Had insomnia for several days, brain zaps, dizziness, but it subsided after a week.

I´ve an update, a rather confusing one or maybe.... I won´t know.

 

Regardless, My psychiatrist put me on Sertraline (Zoloft) and that that caused worsening symptoms of depression and insomnia. I called him and he said that unless the symptoms make me go wild, I should stick to it and see if things ease up and if the side-effects subside let´s see in 20 days. No way I can stay awake for 20 nights! I´ve tried six days and I felt like a zombie due to the lack of sleep. He is adamant on putting me on a combination of Mirtazapine and something else for daytime. Clearly not working in my experience.

 

Yesternight, at my own risk, I tapered the Mirtazapine to 7.5 mg and had an okayish sleep (could deteriorate with time with a 50% reduction in dose). An encouraging news,, the early morning heart palpitations were minimum, my thinking was clearer and sharp, the akathisia was almost non-existent).

 

Till, till however I´d my lunch. Immediately after my lunch, the akathisia is back in full force, my thinking is clouded! Where the hell lies the connection between my psychological symptoms, especially the akathisia, and my diet?!

 

 

Edited by Isaiah2017
Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

 Share

  • Similar Content

    • By Blahblah
      Has anyone (without a clinical thyroid disorder) tried Cytomel and had benefit with depression & fatigue? It seems most docs are resistant to trying it due to the possible heart/ bone density side effects.
      Even when it comes to thyroid disorders, There are some circles that disagree with the TSH lab ranges (what is "acceptable") and that TSH may not be good indicator of thyroid function for everyone anyway...
      I know T3 is rarely prescribed (even for ppl with thyroid issues). But I also read that in a few studies, folks with treatment-resistant depression (with no thyroid issues) can also benefit from using T3 as an add-on or "booster".
       
       
    • By Blahblah
      I banged my head (outer eyebrow near temple) a week ago, on a cabinet door. I'm wondering if anyone here has got a concussion from this sort of thing? How do you know for sure?
      I iced it for an hour immediately, so very minimal bruising, but had a large lump (which is going down). Its very tender. My temple and eyebrow still feel "achey" (it's not really a headache). I also feel extra lethargic with brain fog, abrupt worsening of mood. I go to doc tomorrow, but I read that MRI scans cannot show mild concussions (only bone fractures or brain bleeding) and I also wonder if it's just my depression getting worse (versus a head injury from a bump)...?
      I HATE going to the Dr for this sort of thing... because I don't want to be labeled as "malingering" or a hypochondriac mental case. Doctors always see a diagnosis of depression on my file (and meds I'm on) and of course (being a woman also), it makes them more apt to always write things off as psychological or stress-related. 😞
    • By Inanlae
      So for seventeen years I've had pain depression.  It especially feels like it's squeezing my heart.  It hasn't historically been *about* anything.  I've just chalked it up to biochemistry, heredity.  And I've thought about suicide, most days, for at least fifteen years - because pain sucks.  Ups-and-downs.  Roller-coasters.  Probably every person on here has done time at the worst torture theme park in the world.

      Two years ago, my cocktail started working.  There was some CBT and DBT in the mix too.  I decreased my daily Ativan from 3mg to 2mg.  Plus 20mg Latuda, 300mg Sertraline, 100mg Topamax.  I actually felt happy, for about two years, until this October.  Then it stopped working.  And I stopped working.  I work in a level I trauma center, where I identify cancer, anemia, and the effects of the coronavirus on the human body.  I feel like I have a front row seat to human suffering, without being empowered to ameliorate it, and it's another kind of torture.

      I am very tired of fighting.  If there was a euthanasia travel agency, where I could just walk in, plan my funeral and end-of-life arrangements, plan my ideal death, and just call this thing at 38, that would be a somewhat attractive option (not telling, The Tallest Man on Earth, flaming-Viking-burial-at-sea.)  I'm tired of fighting this disease, personally.  And I'm tired of coming up against the tsunami of "world suck" (H/T Vlog Brothers) which seems to be hate-fucking itself ad astra.

      So the strain theory, which I haven't read much on yet, is that we consider the termination of our lives when under one or more types of strain.  I personally find this theory hopeful, as targeting the sources of strain, i.e. "world stuck," could reduce the inducements to terminate one's life.  The General Strain Theory, according to one Wik I. Pedia cites loss of positive stimuli, addition of negative stimuli, or the inability to reach a desired goal, as three possible sources of strain.  I will follow up on this with my tdoc on Wednesday.  I think work is introducing negative stimuli, and I have a shit ton of unreached goals, but am starting to care about goals less and less.  Basically, it pisses me off that I've had to dramatically reduce my goals due to my diseases, and it's kind of tempting to just leave the party.  Please feel free to weigh in if you have personal and or academic experience with this.

      I'm also meeting virtually with my pdoc tomorrow... to tweak the cocktail.  Would love recommendations.  My current rx mix, dxs and rx, failures are in my signature.  Lamictal induces hives and vomiting.  Depakote causes dyskinesia.  Lithium ruined the thyroid and causes acute renal failure.  Medicine.  Ha ha.  Organ roulette.

      So the observation about different species of depression is that while for a decade-and-a-half I experienced what seemed like purely biochemical, chains-around-my-heart, tar-and-shark-filled, basements-beneath-basements depression.  This feels more like a rational(?) depression, which has me concerned about whether it will be responsive to biochemical therapy.

       
    • By Persona_Is_Life
      Hello! 
      I'm trying to figure out how to address my nervous tics lately. They've been persistent this past year and are always changing. From eye blinking, to head shaking, to sticking my elbow in my sides, squeaking, to a eye closed swallow things. I can't remember them all. 
      I don't always have them. If I've properly slept and aren't stressed/anxious they don't exist at all. As I'm typing this I keep needing to pick up my thumbs and bend them till I hear something crack. 
      I don't know where to put this though! 
      Thanks!
    • By Blahblah
      This has become the central topic of my latest ruminations...I'm still in my 40's, but I'm worrying a lot about getting older. I'm having some random health issues (aches/pains, chronic fatigue etc) that I never had before.
      I don't have any children and get triggered every time I see photos of other people's kids (literally everyone I know my age has kids now). I know that it's not a given that all families are happy or one's kids will take care of you in old age, but it's just the thought of having a family around! My parents are approaching late 70's and they live very far away, cannot travel. I have no other close family (or even close friends) that I can really depend on.
      Anyone know how to remedy these anxious thoughts? One of my biggest fears is being alone in old age, with increased health issues, and being totally isolated/alone in despair. I'd rather die young.
×
×
  • Create New...