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Hey all,

I have been experiencing some anhedonia lately and just not experiencing feelings much at all in general. I feel like I don't want to talk to as many people or interact like I usually would. There's is't much pleasure in doing the things I usually do, and simple things like showering or going downstairs to get my mail are difficult to get the motivation to do it. I don't think I am depressed because I'm not feeling sad or unhappy, I am more just suffering from lack of ability to derive pleasure from things that once gave me pleasure and a general lack of emotions. 

I notice the anhedonia is especially noticeable when I am on my ADHD medications and it really sucks. Given the other medications I am on, it could easily be due to one of the other medications or a combination. Does anyone else experience lack of emotions and/or anhedonia when they are on their ADHD medications? What about when you are off them/you have 'come down' from the drug. I can feel my emotions, they just seem heavily suppressed. I can feel happy, sad, excited, but to a small degree compared to before, I guess the beginning of the year. You can see the rest of my medications in my signature if you want to comment on any of those in relation to this.

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@mmaryland How long have you been on the stimulants and your other meds? Do you think you have grown tolerant and need a higher dose? Many meds can cause or contribute to anhedonia, lack of feelings, numbness (particularly Lithium and SSRI's, possibly Seroquel too). I've heard from many people that have taken stims for a  long period and then stopped, experience a higher degree of anhedonia and no motivation.

The reason I went on a stimulant was to not only improve my cognition/focus, but get rid of these symptom of low motivation, lack of pleasure. It seemed to help more in the first 1-2 months of taking it, it seemed to also brighten my mood, but now it just helps me focus. I feel anhedonic all of the time - but it is much worse when I don't take the stim or when it wears off.

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Amphetamine works against anhedonia for me. It is thought that anhedonia is a dopamine issue and amphetamines effect mainly dopamine. That is why Wellbutrin works on anhedonia 

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On 8/21/2017 at 9:02 AM, Blahblah said:

@mmaryland How long have you been on the stimulants and your other meds? Do you think you have grown tolerant and need a higher dose? Many meds can cause or contribute to anhedonia, lack of feelings, numbness (particularly Lithium and SSRI's, possibly Seroquel too). I've heard from many people that have taken stims for a  long period and then stopped, experience a higher degree of anhedonia and no motivation.

The reason I went on a stimulant was to not only improve my cognition/focus, but get rid of these symptom of low motivation, lack of pleasure. It seemed to help more in the first 1-2 months of taking it, it seemed to also brighten my mood, but now it just helps me focus. I feel anhedonic all of the time - but it is much worse when I don't take the stim or when it wears off.

I have been on stimulants since I was 18 years old and I no doubt believe I have grown tolerant and need a higher dose. I started with Adderall XR 20mg then moved to 30mg XR, a couple months later I moved to Vyvanse 70mg and switched back and forth between that and Adderall XR a few times. The efficacy of Adderall was going down and side effects were increasing so I switched back to Vyvanse and eventually to Dexedrine Spansules 10mg twice daily and Dexedrine IR 10mg twice daily earlier in 2017. Since then I have increased to Dexedrine Spansules 15mg twice daily but kept the Dexedrine IR (actually I take the brand Zenzedi) 10mg twice daily.

I have wondered if the Lithium is causing it or Seroquel, but it mainly happens when I am on my stimulant medications. I usually take my Dexedrine everyday, so I never am stopping and then re-starting my stimulants. I am wondering if switching back to Adderall IR in the evening instead of Zenzedi would give me more motivation. The Dexedrine is just soo smooth it's almost unnoticeable, and I feel like I need that extra boost to get started on things that levo-amp could provide.

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