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Hello, I'm on Trintellix/Brintellix (Vortioxetine) 15mg and Valdoxan (Agomelatine) 25mg. I've got a history of being very sensitive to side effects and have tried a ridiculous number of medications. Currently I'm having sexual problems which have the potential to ruin my life and my beautiful relationship. The conflict I'm going through is of course that depression can ruin my life also so I'm very very torn. Does anybody have any idea which is more likely to be causing the numbness in my clitoris out of Brintellix and Valdoxan? I'm willing to put up with side effects within reason, but not this. To me, it would be like eating without taste. Any insights would be much appreciated. I do discuss all of this with my doctor but I feel as if I'm not being taken seriously.

Edited by Unburdened
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I don't know the answer but I'd encourage you in being persistent with your pdoc. They don't seem to take sexual matters seriously, I wonder if it's worse with women or just in general. I flat out had to change meds but I'm not familiar with yours so can't help there, just wanted to offer some support here. 

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Two of your pharmaceutical  options are Wellbutrin and cyproheptadine. The Wellbutrin is taken all the time  in addition to your other meds; 150 mg XL is the dose I see others using. Cyproheptadine is an old, 1st generation antihistamine. It reduces the effect your AD is having on serotonin for a few hours after taking 1 dose. Taken an hour before activities. Serotonin seems to have something to do with sexual dysfunction in men and women as most of the AD's that effect it can cause sexual dysfunction.

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  • 2 weeks later...

Just wanted to give an update on my situation. I completely stopped the Trintellix/Brintellix (Vortioxetine) and am still on Valdoxan (Agomelatine) but doubled the dose to 50mg. I'm back to normal sexually so it was definitely the Vortioxetine that caused my numb clitoris. The Agomelatine by itself does bugger all for my depression though so I don't know what the next step is. I do have an appointment next week. Unfortunately here in Australia I do not have the drug options you have in the USA. I'm aware of the good benefits of Wellbutrin but my understanding is that here I can only be on it for 2 months for stopping smoking. I'm wondering if I can get hold of it "illegally" - will discuss with the Dr. I'm very frustrated and feel that I am at the end of my tether. My options are very limited due to my problems with SSRIs and the fact that my depression is worsening and I feel that I'm slowly drowning at times. When the water goes over my head what am I meant to do without good medication options available to me? To lose sexual feelings is a deal breaker no matter how good the drug makes me feel mentally. I could feel the Vortioxetine lifting my depression in a really positive way, but at too high a cost. I'm caught between a rock and a hard place. Being drug free would result in my relationship suffering due to my depression, and being on drugs would make my relationship suffer due to not being able to orgasm. To not be able to orgasm would be like having a beautiful part of my personality cut out and destroyed. Sometimes it feels as if the suffering/frustration/nightmare/sacrifices will never end and that there is nothing to look forward to. 

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I don't know your meds or Australian rules. Wellbutrin worked for me, as did Cymbalta/duloxitine, with no sexual issues. But Wellbutrin sounds not an option for you, which seems odd. Maybe the other one?  I totally get the sexual aspects, wish I had some useful advice. Ultimately I switched to lamotrigine but that may not be an option for you, either, plus I suspect meds may not be the same for everyone with regard to sex. I've been down this path and really I think pdocs don't always take this issue seriously. 

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  • 3 weeks later...
On ‎3‎/‎08‎/‎2017 at 1:39 PM, sugarsugar said:

I don't know your meds or Australian rules. Wellbutrin worked for me, as did Cymbalta/duloxitine, with no sexual issues. But Wellbutrin sounds not an option for you, which seems odd. Maybe the other one?  I totally get the sexual aspects, wish I had some useful advice. Ultimately I switched to lamotrigine but that may not be an option for you, either, plus I suspect meds may not be the same for everyone with regard to sex. I've been down this path and really I think pdocs don't always take this issue seriously. 

Coincidentally I'm now on Lamotrigine also, with Agomelatine.

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I'm no help but I'm in Australia and have had the same problem. Deal breaker for me too. Feels a bit no win and frustrating that here you can only get Zyban if you're quitting smoking. Feels so behind. How are you going with the above combination? 

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17 hours ago, Jessamine said:

I'm no help but I'm in Australia and have had the same problem. Deal breaker for me too. Feels a bit no win and frustrating that here you can only get Zyban if you're quitting smoking. Feels so behind. How are you going with the above combination? 

Hi Jessamine, I'm not sure how the drug combination is going yet as I'm only 4 days into it. I did mention Zyban to my psychiatrist and he did say that it might be possible to get onto it if the Dr writes to Canberra to get permission. Also, there is an online pharmacy that sells Zyban - 150mg 90 $162.60. It's a legitimate online pharmacy called Sydney Drugs. Here is their website: https://sydneydrugs.com/

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6 hours ago, Unburdened said:

I'm not sure how the drug combination is going yet as I'm only 4 days into it

Oh I'll be interested to hear how you're going later on :) Thanks for updating me though! Sounds like a whole lot of effort just to get approval to take zyban to counteract other side effects. I'm currently unmedicated (insanely sensitive to sides and ALL of them have killed off this ability). I need something though, I'm exhausted from my own mind at the moment. Thanks for the link. I'll check it out!

 

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