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Potential Adverse Effects of Amphetamine Treatment on Brain and Behavior: A Review


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Potential Adverse Effects of Amphetamine Treatment on Brain and Behavior: A Review

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Beyond the characterization of generally safe treatment protocols, it is important to identify protective factors. As noted above, a genotype that codes for lower density of dopamine D2 receptors (compared to a parallel functional polymorphism), protects against amphetamine-induced psychosis 198. Treatment with either lithium or valproate reportedly protect against dextroamphetamine-induced alterations of brain choline concentration in patients with bipolar disorder 216. Recent studies in animals have produced evidence for neuroprotection against amphetamine-mediated toxicity by several substances, including nomifensine 217, methyllycaconitine 218, coenzyme Q10 219, baicalein 220 and melatonin 221. In addition, impairment of learned place preference consolidation by amphetamine-induced neurotoxicity was ameliorated by administration of a glutathione precursor 222.

 

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