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Questions about my new Med

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Hi all,

Im new here so bare with me.Ive suffered with Depression and Anxiety and OCD all of my life and a few years back I learned I had Bipolar Disorder and my pdoc started treating me with every antipyschotic there is and everyone of them(Risperdal,Invega,Saphris,Latuda,Geodon,Abilify)gave me a world of side effects like the anti depressants did growing up.The only thing that has help this far has been benzo’s but I use them as last resort due to I dont wanna get addicted.Ok so that leads me to last week when pdoc rx’d me my last chance Seroquel IR 400mg which was to be taking all at night before bed.well the first two days it make me a little tired but after that I can take it like candy without getting the sedation like everyone else so I started to take it in the morning with the rest of my meds but Ive noticed it seems like it doesnt matter when I take it its not lasting 24hrs.I mean for the most part Im doing well for only being on it for 11 days but Im still having a slight problem with anxiety and irritablity and intrusive thoughts.Maybe I havent taken it long enough?Maybe I need a higher dose?Maybe I need the XR?When she rx’d it to me I asked for the XR and she flat out refused and I dont know why,maybe because Im on call 24hrs a day with work,I see her again on the 11th of Jan and Im gonna again ask for the XR and see what she says,I do remember her saying it wasent generic,maybe that was the reason which I know it is because I was told at the pharmacy it was,anyway,I know everyone is diff and reacts diff on meds but I need all the advice and support I can get with this med because I like it the best out of them all.I also take Lamictal 300mgXL, and Topamax200mg, Thanks in advance.






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  • 2 weeks later...

IR doesn't last 24 hours (which is the purpose of XR...) so I'm not surprised. Do you get any relief after you take it for even a little bit? It's possible your doctor wants to see what you can tolerate before switching to an XR med. This is definitely something you should discuss with your doctor. I hope she's responsive to your concerns.

Also, Seroquel XR came out as generic about 6? months ago. 

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  • 1 month later...
On 1/4/2018 at 1:05 PM, Iceberg said:

What about splitting the dose BID? 

^^^ that's what I would do. Quetiapine itself doesn't have a particularly long half-life (7 hours), but its metabolite norquetiapine has a half-life of 9-12 hours. Still probably wouldn't make it all the way through the day though.

I remember having this issue with loxapine too. The shorter half-lives are nice because of fewer side effects during the day but just the same you also sacrifice effectiveness. A lot of people swear by the Seroquel XR though.

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