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Did anyone experience symptoms of IBS when taking Lamotrigine?

It could be Lamotrigine

Vegan products 

I don't know but I think it's the Lamotrigine 

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Lamotrigine does not affect serotonin, a major culprit in GI upsets. It is unlikely it is the Lamotrigine.  

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On 1/20/2018 at 3:11 PM, notloki said:

Lamotrigine does not affect serotonin, a major culprit in GI upsets. It is unlikely it is the Lamotrigine.  

Actually believe it or not, lamotrigine does have affinity for monoamine systems:

https://www.ncbi.nlm.nih.gov/pubmed/9809864

The only actual receptor that it touches is 5HT3 and that affinity is weak, but antagonism at that receptor would inhibit GABA firing which could explain some of the activation and anxiousness that people feel when starting lamotrigine. Antagonism of 5HT3 also is shown to induce acute changes in the gut that suppress nausea and vomiting (e.g. Zofran, a 5HT3 antagonist). It does also have a weak inhibitory effect on serotonin, norepinephrine, and dopamine transporters. These certainly aren't its primary effects. Particularly in bipolar disorder the first and foremost important effect of lamotrigine is reduced glutamate neurotransmission.

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5 hours ago, browri said:

Actually believe it or not, lamotrigine does have affinity for monoamine systems:

https://www.ncbi.nlm.nih.gov/pubmed/9809864

The only actual receptor that it touches is 5HT3 and that affinity is weak, but antagonism at that receptor would inhibit GABA firing which could explain some of the activation and anxiousness that people feel when starting lamotrigine. Antagonism of 5HT3 also is shown to induce acute changes in the gut that suppress nausea and vomiting (e.g. Zofran, a 5HT3 antagonist). It does also have a weak inhibitory effect on serotonin, norepinephrine, and dopamine transporters. These certainly aren't its primary effects. Particularly in bipolar disorder the first and foremost important effect of lamotrigine is reduced glutamate neurotransmission.

Lamictal touches just about everything, just a little, even an opioid receptor but none of it is significant except for pissing contests.

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9 minutes ago, notloki said:

Lamictal touches just about everything, just a little, even an opioid receptor but none of it is significant except for pissing contests.

Eh...who's pissing?

It's good to know anyway. I hardly think people would take the time to publish research if it was clinically insignificant.

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