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 Does this happen anyone else. About 45 minutes after I take my Seroquel my nose becomes completely stuffed , it’s out of no where and. Have to use afrin to knock jt out it’s so bad, I know I can’t keep taking afrin but crap it’s terrible. Then I just get rebound congestion

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I used to become really congested/allergy feelings when taking lower dose Seroquel and the same effect happened with Risperdol.. I think it has something to do with their effect on Histamine receptors. Now it is said that at very low doses, Seroquel acts primarily as a histamine receptor blocker (antihistamine) causing more drowsiness,  and at higher doses, it affects different adrenergic system and serotonin/ dopamine receptors. I'm no pharmacologist, but maybe there's a link in this?

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