catotheyounger Posted February 10, 2018 Share Posted February 10, 2018 So I've taken Rexulti for 2 days, and both days I woke up in the middle of the night. So my questions are: 1: I read that taking it in the morning could help, but the half life is 91 hours, so I'm not sure how much difference this would make. How much does this actually help? 2: Does it go away on its own as your body acclimates to the drug? 3: Is there anything else I can do to help it? 4: Should I stop taking it? Link to comment Share on other sites More sharing options...
Iceberg Posted February 10, 2018 Share Posted February 10, 2018 For me higher dose caused almost no issues...lower dose is pretty activating Link to comment Share on other sites More sharing options...
CeremonyNewOrder Posted February 10, 2018 Share Posted February 10, 2018 Watch out....abilify gave me severe insomnia which then pushed me into a manic episode. I'd contact your pdoc to be on the safe side. Link to comment Share on other sites More sharing options...
catotheyounger Posted February 11, 2018 Author Share Posted February 11, 2018 18 hours ago, Iceberg said: For me higher dose caused almost no issues...lower dose is pretty activating Can you elaborate on this? Taking it earlier in the day didn't seem to help, I still woke up in the middle of last night. Should I keep taking it? Link to comment Share on other sites More sharing options...
Iceberg Posted February 11, 2018 Share Posted February 11, 2018 Well at 2mgs and below it kinda acted like an antidepressant...above that I lost the activation but also some of the antidepressant effect Link to comment Share on other sites More sharing options...
browri Posted February 11, 2018 Share Posted February 11, 2018 YMMV on that though. I started Rexulti at 0.5mg in the morning and found it to be sedating 2-4 hours after taking it but simultaneously subtly stimulating. Worked almost synergistically with the Vyvanse. It was weird. Moving to evening time resolved the daytime cognitive issues for the most part but I was having trouble adjusting to it so we dropped to 0.25mg. About 1-2 weeks after that everything smoothed out. But I still take it at night and consider it to be sedating. I'm also taking it with Depakote though so that may be helping me sleep if the Rexulti is causing any disturbances. Link to comment Share on other sites More sharing options...
catotheyounger Posted February 11, 2018 Author Share Posted February 11, 2018 fuck, I guess I just gotta call my psydoc tomorrow and see what he tells me to do then. Link to comment Share on other sites More sharing options...
Iceberg Posted February 11, 2018 Share Posted February 11, 2018 Yeah I should mention tho that I was also on adderall at the time so my data is skewed. I was the first patient on it for my pdoc so the dosing was basically experimental... I've certainly heard of people like browri who have the opposite effects. I think that's been a tricky part of the newest aaps like. Vraylar and rexulti...the effect as far as activation/sedation Link to comment Share on other sites More sharing options...
catotheyounger Posted February 11, 2018 Author Share Posted February 11, 2018 I'm taking it as an antidepressant, not an antipsychotic. Link to comment Share on other sites More sharing options...
browri Posted February 11, 2018 Share Posted February 11, 2018 3 minutes ago, Iceberg said: Yeah I should mention tho that I was also on adderall at the time so my data is skewed. I was the first patient on it for my pdoc so the dosing was basically experimental... I've certainly heard of people like browri who have the opposite effects. I think that's been a tricky part of the newest aaps like. Vraylar and rexulti...the effect as far as activation/sedation Yeah and me taking Vyvanse in the morning certainly helps to "right" my sleep cycle so that could be helping me sleep at night in a sense. @catotheyounger what dose are you taking? Link to comment Share on other sites More sharing options...
catotheyounger Posted February 11, 2018 Author Share Posted February 11, 2018 I got one of those sample packs that's 0.5 for a week, then 1. Link to comment Share on other sites More sharing options...
browri Posted February 11, 2018 Share Posted February 11, 2018 Just now, catotheyounger said: I got one of those sample packs that's 0.5 for a week, then 1. Then I would say give your doctor a call and ask if you can try the 0.25mg. That made all the difference for me. I think I'm going to try going back up to 0.5mg here in a few weeks because I've been noticing a mood shift lately that I want to stay on top of, but my experience was that Rexulti took a long time to adjust to, and if you really stuck with it that it was totally worth it. But I didn't feel that way until after I had been on 0.25mg for like 2 weeks. Link to comment Share on other sites More sharing options...
Iceberg Posted February 11, 2018 Share Posted February 11, 2018 (edited) that's how I started too (for BP Depression) "Supposedly" the target dose is 2 mgs for depression (medscape) but why take that if you don't need it...so maybe .25 would be worth a shot if .5 is too activating Of course that's ur pdocs call as to whether the cost will eventually be outweighed by the benefits Edited February 11, 2018 by Iceberg Link to comment Share on other sites More sharing options...
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