argh Posted February 22, 2018 Share Posted February 22, 2018 (edited) . Edited September 16, 2020 by argh 1 Link to comment Share on other sites More sharing options...
jt07 Posted February 22, 2018 Share Posted February 22, 2018 Yes, this is a better fit for the antidepressants forum and so I am moving it. Link to comment Share on other sites More sharing options...
Blahblah Posted February 22, 2018 Share Posted February 22, 2018 Interesting, thanks for posting. I have been wanting to see a recent study like this for some time. Have you guys ever even heard of Agomelatine? I'm not familiar with that one at all. (From link above) Outcome (for acute treatment of Major Depressive Disorder): In head-to-head studies, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were more effective than other antidepressants (range of ORs 1·19–1·96), whereas fluoxetine, fluvoxamine, reboxetine, and trazodone were the least efficacious drugs (0·51–0·84). For acceptability, agomelatine, citalopram, escitalopram, fluoxetine, sertraline, and vortioxetine were more tolerable than other antidepressants (range of ORs 0·43–0·77), whereas amitriptyline, clomipramine, duloxetine, fluvoxamine, reboxetine, trazodone, and venlafaxine had the highest dropout rates (1·30–2·32). 46 (9%) of 522 trials were rated as high risk of bias, 380 (73%) trials as moderate, and 96 (18%) as low; and the certainty of evidence was moderate to very low. Link to comment Share on other sites More sharing options...
dancesintherain Posted February 22, 2018 Share Posted February 22, 2018 anyone know what " the certainty of evidence was moderate to very low " means? Is that essentially saying that the study results can't be trusted or does it mean something else? Link to comment Share on other sites More sharing options...
argh Posted February 22, 2018 Author Share Posted February 22, 2018 (edited) . Edited September 17, 2020 by argh Link to comment Share on other sites More sharing options...
Ion Posted February 22, 2018 Share Posted February 22, 2018 4 hours ago, dancesintherain said: anyone know what " the certainty of evidence was moderate to very low " means? Is that essentially saying that the study results can't be trusted or does it mean something else? Based on another section I believe they are describing the predicted reliability of the studies they included in the meta-analysis. From the snippet below the results around the first list of meds should carry more weight than those about the second list. Quote We incorporated the GRADE judgments in figure 4. The certainty of evidence for the relative treatment effects of efficacy and acceptability varied; it was moderate for most of the comparisons involving agomelatine, escitalopram, citalopram, and mirtazapine, and low to very low for most comparisons involving vortioxetine, nefazadone, clomipramine, bupropion, and amitriptyline I've been getting good use out of a meta analysis I found on treatment-resistant depression. I'll link it in case anyone else might find it useful https://www.ncbi.nlm.nih.gov/pubmed/26425446 1 Link to comment Share on other sites More sharing options...
maxor Posted March 6, 2018 Share Posted March 6, 2018 here you go: https://psychotropical.info/lancet-21-antidepressants-meta-analysis/ Link to comment Share on other sites More sharing options...
notloki Posted March 6, 2018 Share Posted March 6, 2018 Quote All antidepressants were more efficacious than placebo in adults with major depressive disorder. 1 Link to comment Share on other sites More sharing options...
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