How can sulpiride make you happy??

[shweaty]

I'm on lamotrigine 300mg and was on quetiapine 100mg but it was making my thoughts worse and my mood still wasn't great, that's an understatement, my moods are vile.. didnt help that it made me put on 5kg in 2 weeks!!! I am mostly depressed nowadays.. anyway I begged him to put me on latuda as that had less side effects and treats bipolar depression. He bluntly refused and put me on sulpiride. I don't understand how blocking my dopamine will make me happy AT ALL! please help and enlighten me.. I'm at my wits end with this medication business and I feel like just quitting it all and allowing myself to be whatever it is I am weather it's dangerous or not -_____- so confused and angry about it !

[MiaB]

Moved to antipsychotic forum.

[notloki]

It hits some of the serotonin sites that antidepressants do. It does more that just block dopamine, I fact most AP's have some antidepressant effects due to their actions with serotonin. 

[shweaty]

28 minutes ago, notloki said:

It hits some of the serotonin sites that antidepressants do. It does more that just block dopamine, I fact most AP's have some antidepressant effects due to their actions with serotonin. 

Isn't dopamine the pleasure, motivation ect part of the brain? I dont see at all how it can help if those parts are gone? How can you be happy without being able to get please for anything and cant be bothered to do anything at all? Just the fear of these things alone are already making me panic and angry.. I'm over the top agitated and quicktempered.. I'm just so scared of not getting better ? my children and partner have had to put up with all this up and down for 2 years I can't put them through any more it's killing me ?????

[mikl_pls]

In low doses, it preferentially antagonizes the presynaptic dopamine autoreceptors, causing dopamine release.

Quite honestly, I wish we had sulpiride, amisulpride, and flupenthixol in the US for this reason. Right now the only medicine we have that does this is buspirone.

Edited March 8, 2018 by mikl_pls