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Hey there! I've been having a very difficult week. I've been on lexapro and klonopin for depression and anxiety for 3 years and the lexapro has plateaued in the last year or so, so my pdoc decided to put me on Abilify about a week ago and it has SUCKED. I'm not feeling any of the positive effects of the meds yet, which I understand because sometimes it takes a while. BUT i have been feeling a whole bunch of negatives. Theres a general brain slowness, like forming sentences and thoughts takes much longer than usual, like if my train of thought were a real train, there is now a huge parachute on the back slowing it down. 

The WORST side effect so far has been the derealization. I'm familiar with it as it is a side effect of my anxiety. I can't tell if it is a direct effect of the abilify or if the meds are causing more anxiety which is then causing derealization. The thing is, I haven't been feeling much more anxious than usual recently. It's like the derealization comes over me first and then the anxiety follows. 

Has anyone experienced this on Abilify? If so, did it go away eventually? Did you switch meds? Nothing seems real and I'm getting very very tired of it. 

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I had terrible anxiety on Abilify until I reached 10 mg and then the anxiety went away and it began to work, and it worked amazingly well. If your dosej of Abilify is low, it could be causing your anxiety to increase. I can't say I've had derealization from Abilify though.

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jt07 thank you for the feedback! I'm only on 2mg right now, increasing makes me nervous as it might cause weight gain and i've got ED history. Have you ever been on Wellbutrin? if so did it also increase anxiety? 

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Yes, I have taken Wellbutrin and it did cause anxiety. It's known to cause anxiety, I think. 

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