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I've been on Abilify for about a year and a half now. It has been the best AAP for me as far as mood stability and help with bipolar depression goes. But I have this nagging suspicion that it has really screwed up my cholesterol... Before I went on it, my cholesterol was fine, but not long thereafter, my cholesterol was a little messed up... I started it in August of 2017 and by October of 2017, my cholesterol was as follows:

  • Total cholesterol: 187 mg/dL (10-199 mg/dL)
  • HDL-C: 10 mg/dL (30-72 mg/dL)
  • LDL-C: 129 mg/dL (0-128 mg/dL)
  • Triglycerides: 220 mg/dL (40-160 mg/dL)
  • vLDL-C: 44 mg/dL (5-40 mg/dL)
  • Chol/HDL ratio: 18.70 (0.00-5.00)

It wasn't terrible, I guess, as they didn't put me on a statin at the time. They just said "lose weight and diet," which I was already doing both of at the time. I just made it a point to do it more. I went to the gym and exercised, but I eventually fell out of doing that.

Fast forward to last month, I had my testosterone checked because of various reasons (mostly depression, inability to lose weight, what appears to be gynecomastia), and while my testosterone is okay (which it has been low and they've said it's okay before... I have yet to get a copy of the blood test results), they said that my LDL cholesterol was "very high" and my HDL cholesterol was "very low" (I assume it hasn't budged from 10...) and that my doctor wanted to put me on Lipitor 20 mg.

So he called it in and I started taking it, hoping it will make a difference. I plan on getting a copy of my blood test results, like I said, and I do plan on going back to the gym. I don't know what I've been doing wrong, or if it's the Abilify. I'm eating right, or so I think I am... 

Has anyone had problems with dyslipidemia from Abilify? It's supposed to be metabolically friendly!

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I don't have any personal experience with Abilify yet.......

But according to this article, which is based on figures from FDA reporting,  dyslipidemia is possible when taking Abilify, although it seems to be fairly rare (only 2.11%  of the people reporting had it):



Edited by CrazyRedhead
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2 hours ago, Blahblah said:

Could it be due to a diet change - like Keto (high protein & fats) diet? I don't know if you are still doing that

It's possible. I got of the keto diet a while back though, so I don't know if it would be due to that kind of diet change. Supposedly the keto diet is supposed to be beneficial to cholesterol levels though.

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I already had problems with the lipid numbers as I was a diabetic (dyslipidemia comes along with diabetes) before I started taking Abilify. Adding Abilify did not change the results of my lipid panel. It did not change any of my lab results.

Yes, Abilify can cause weight gain, insulin resistance, hyperglycemia, and dyslipidemia in some people. It is just the least likely AAP to do so and the incidence is quite low for these side effects.


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