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Which is the most sedating anti-psychotic?


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I've been on quitiapine, olanzapine, chorpromazine, haloperidol, resperidone and sulpride.

The typicals were besically just to calm me down.

I didn't find any of them all that sedating, though most left me with a slight hangover (I wasn't taking low doses either).  Seroquel helped me to stay asleep.

Which is the most sedating AP?

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Amisulpride - no sedation.

Seroquel is sedating for me.....more so as the dose increases. I've been on Zyprexa before and also found it to be sedating. With both, i have no choice in staying awake.....they'll each put me down eventually.

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  • 3 months later...

I don't find Zyprexa sedating in the slightest but Risperdal knocked me for six, seroquel too. No sedation from Amisulpride or Abilify. There are a tonne of sedating old school antipsychotics like Zuclopenthixol/Clopixol (mostly used as a depot injection) and good old Largactil/Chlorpromazine. I don't get any sedation from Haldol and Stelazine/Trifluoperazine is more activating as well.

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with seroquel at 50 mg there was just one hit - me on the floor. it worked, and still works, very well for this. at 25 mg i was the professed slobbering idiot that loon described. daytime, nighttime, it made no difference cos i was horizontal. i'm at 75 mg now and it works very well for sleep. but its main benefit to me is as an atypical anti-depressant, and for reducing obsessive thoughts. it's my magic pill so far.

good luck,

grouse.

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Seroquel is my magic pill, too. I take anywhere from 125 mg to 250 mg on a regular basis--I take it all in one dose at night, it knocks me out, I sleep from 8-11 hours like a baby and I used to be a horrible insomniac, but I am not sedated during the day. It stops racing/obsessive thoughts and is a general mood stabilizer for me.

Should add that it was a great anti-manic when I was totally out of my mind manic, but I had to take a really high dose for that, up to 600-800 mg for several days. Then I was really out...

~Cat

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Seroquel does okay (off and on not every single day) at 100 mgs. I also take ambien though. Even though sometimes that won't work if my mind is on overdrive. Zyprexa does zero for me in terms of sleep. My trick is to take klonopin to relax me(two hours before bed), seroquel to quit the noise in my head(one and a half hours before bed), then ambien(one hour before bed) to finish me off. it's a crapshoot but a lot of times it works. My zyprexa is for emergencies only.

Lilie

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I also think lower doses of Seroquel are a total knockout drug. Then again I can only compare it to Risperdal and Abilify, which aren't sedating at all (for me, anyway). Seriously, though, Seroquel knocked me out every time; and I was only on 100mg.

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