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So, I went to see my GP to talk about possibly switching from Prozac to something else. I am not sure if my Prozac is pooping out or if it just normal life stressors getting to me. So, I discussed this with him and he had me do some genetic testing to see if I metabolize psychiatric meds normally. I got the results back, and apparently the only abnormal thing is that I have a gene mutation that makes me unable to metabolize folic acid properly, so he prescribed something called Deplin, generic version L-Methylfolate 15mg. With insurance coverage it is $56 a month!! I am wondering if anyone has had noticeable, positive results from this before I drop $56 on basically a pharmaceutical grade vitamin. I am thinking that maybe I should just go back to seeing a therapist and not go on the med merry-go-round again, since Prozac is still working and life is not so bad to warrant a huge medication change. Maybe possibly going from Prozac 20mg to 30mg? Since 40mg had benefits but I was WAYYYYYYYY too fatigued all the time.

Another thing I want to inquire about is possibly augmenting Prozac with Wellbutrin. I had been on Wellbutrin 150mg XL 4 years ago, and I think I liked it but it made me VERY irritable. The difference then is that that was my main antidepressant, second one being Remeron 15mg, but that was mostly for sleep. I am wondering maybe the Prozac has leveled me out more so I will not be as irritable from the Wellbutrin. Anyone had success with an SSRI + Wellbutrin? Thank you all.

Edited by icygrave
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1 hour ago, gb84 said:

I had the gene test as well and take L-Methylfolate daily.  Unfortunately it hasn't improved a thing.  Don't waste your money on Deplin, it's a ripoff. 

 

That's exactly what I suspected, how disappointing. Ridiculous that a damn vitamin is sold for $56. Insanity. Thanks for sharing your experience.

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2 hours ago, icygrave said:

That's exactly what I suspected, how disappointing. Ridiculous that a damn vitamin is sold for $56. Insanity. Thanks for sharing your experience.

Np. 

I wish it would have worked.  I had two months of Deplin samples, then I bought some L-Methylfolate on Amazon.  So far no luck using the gene test for anything that works.  My old pdoc sold me on the test saying it would show which meds should work best.  Clearly not the case.  Everything I've tried in the green has failed miserably.  But hey, I'm not bitter or anything. 

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17 hours ago, browri said:

@icygrave what was the name of the test that you took? Was it GeneSight or GenoMind? If you know that is.

It was the Millennium Health Pharmacogenetic Test. Very similar to genesight but cheaper, I think my insurance may completely cover the cost and if not the max I would pay is $249. Tests for ADHD medications, anticonvulsants, SSRIs/SNRIs, Tricyclics, MAOIs, miscellaneous ADs such as wellbutrin, trazodone trintellix etc. Antipsychotic, both typical and atypical, and benzodiazepines.

I would say the test is definitely worth looking into. Not only did I find out I have two MTHFR gene mutations, but I also am more suspectiable to weight gain from Olanzapine, Clozapine, and a third one I forget. Also found out I metabolize Diazepam, Lorazepam and Oxazepam a bit slowly so levels of the drugs build up in my system higher than normal. Very very interesting!

 

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@icygrave I never got one of those tests done. I always did the research myself using my AncestryDNA and 23andMe data on SelfDecode and GeneticGenie. I'm pretty sure I have hammered down where my issue stems from, and I'm also taking medications that conform to those gene "requirements" pretty well. I would still be curious to see the results for myself though. The Genomind test is more likely to be similar to what you took. Genesight doesn't look into as many neurological genes as it does metabolic genes, like whether you'll metabolize a drug too quickly or too slowly. Ultimately though, I was able to get more information out of my raw data using SelfDecode than those reports seem to provide. I was ultimately disappointed and was hoping getting a clinical test like Genesight or GenoMind done would yield more direct results, but it really wouldn't have.

 

Edited by browri
confirm vs conform. One letter makes all the difference
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Those genetic tests are garbage.  Don't waste your money.

Wellbutrin + a SSRI has been part of my cocktail for 20+ years and kept me from the farthest depths of depression.

In all my years on this site, which has been the lifetime of the site, I have never heard a single person say anything positive about Deplin.  

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On 9/29/2018 at 9:41 AM, Velvet Elvis said:

Those genetic tests are garbage.  Don't waste your money.

Wellbutrin + a SSRI has been part of my cocktail for 20+ years and kept me from the farthest depths of depression.

In all my years on this site, which has been the lifetime of the site, I have never heard a single person say anything positive about Deplin.  

 

I think I may just give Wellbutrin a try! Especially since Prozac IS helping, especially with anxiety, I just feel a tad bit "flat", unmotivated, and melancholic at times. May I ask what dose of Wellbutrin you take?

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My pdoc added Wellbutrin to my Zoloft a few months ago. So far it's been an absolute miracle drug. I'm definitely crankier on it than I was on just the Zoloft, but it's not unmanageable and it's well worth it to be able to feel joy again. I haven't been on Wellbutrin by itself, so I unfortunately can't offer any experiences about crankiness on just Wellbutrin vs crankiness on Wellbutrin + AD.

It does sound like it might be worth a try, though. Anhedonia, lack of motivation, and that sort of "flat" feeling are all things it's helped me enormously with. 

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10 hours ago, Sync said:

My pdoc added Wellbutrin to my Zoloft a few months ago. So far it's been an absolute miracle drug. I'm definitely crankier on it than I was on just the Zoloft, but it's not unmanageable and it's well worth it to be able to feel joy again. I haven't been on Wellbutrin by itself, so I unfortunately can't offer any experiences about crankiness on just Wellbutrin vs crankiness on Wellbutrin + AD.

It does sound like it might be worth a try, though. Anhedonia, lack of motivation, and that sort of "flat" feeling are all things it's helped me enormously with. 

That is awesome, I'm feeling positive about it! My psych called in a script of Bupropion XL 150mg, and I'm on my way to go pick it up. I'm hoping I do not get as irritable as I did when I took it by itself, but then again that was so many years ago. I think the Prozac and Klonopin will mellow that out. Thank you for all the help guys!

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