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Cymbalta and serotonin.


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I have been through many ADs, and Cymbalta is by far the best for me.

I understand however that it hits norpinephrine first.

Would I need to go higher to get the full benefit in terms of serotonin?

I ask because I feel that meds that block the reuptake of serotonin help my anxiety.

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I have been through many ADs, and Cymbalta is by far the best for me.

I understand however that it hits norpinephrine first.

Would I need to go higher to get the full benefit in terms of serotonin?

I ask because I feel that meds that block the reuptake of serotonin help my anxiety.

<{POST_SNAPBACK}>

IIRC, it inhibits re-uptake of both receptors at the same time. It's Effexor

that's more noted for that sort of dose dependency... 

I did find an online abstract for research that suggests that duloxetine (Cymbalta) may be a stronger

serotonin reuptake inhibitor than fluoxetine. I suspect it's better at keeping serotonin in

circulation than norepinephrine, but I haven't bookmarked supporting references

for that.

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I have been through many ADs, and Cymbalta is by far the best for me.

I understand however that it hits norpinephrine first.

Would I need to go higher to get the full benefit in terms of serotonin?

I ask because I feel that meds that block the reuptake of serotonin help my anxiety.

<{POST_SNAPBACK}>

IIRC, it inhibits re-uptake of both receptors at the same time. It's Effexor

that's more noted for that sort of dose dependency...

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I was on Cymbalta for quite a while.  The N does kick in before the S where as Effexor is the opposite.  60mg is the theraputic dose.  I was still having anxiety issues so I went up to 90mgs after being on 60mg for one month.... It seemed to help for a while but then I still had a few issues.  I was rx klonopin so I decided to drop the Cymbalta since after a while I felt no difference between 60 and 90mg.  Plus the fact that its very hard on your liver and I was taking WB as well to counteract the sexual s/e.  For me the SNRI was way worse for that s/e than a regular SSRI.  Needed a higher dose of WB to counteract that and then it still was hit or miss whether I could O or not.

The higher doses of C are really for individuals taking it for pain versus an AD.  I've done alot of research on it.  Like I said the 90mg helped for a while but then felt just like the 60mg.  Alot of pdoc's don't want to go above 60mg anyway b/c its very experimental.  I have since switched to an SSRI Lexapro since its more for anxiety and thats my biggest issue.  Hope that helped.

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My experience is the opposite of Bianca's.  Cymbalta helps a lot more with anxiety than any SSRI did, and Lexapro didn't do a thing for me.  I felt horrible on it.

I was on 90 mg Cymbalta for a long time, then 120mg Cymbalta for about 6 mos due to hormonal issues. I'm going back down now because the hormonal stuff is changing (has to do with girly stuff).  Side effects are less with this drug than with SSRI's for me.

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