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I was curious about Abilify, first off have you personally seen a huge increase in weight after getting on abilify? I hardly have an appetite, even without meds, and it's very hard for me to gain weight. I also exercise pretty modestly, about an hour a day. Would I be safe from weight gain caused by Abilify? The only antipsychotic I've been on long term was Seroquel, helped me a lot and I don't think I gained more than 10 pounds, which could've just been me not being so depressed and having an appetite again. Is the same likely for Abilify? I am just terrified of this because I have gained a large amount of weight, over 20 pounds from one medication which was Remeron. It really messed with my body and I am terrified of that happening again, because honestly, being fat makes me feel ugly and even more depressed.

Second, I wanted to talk about something my   psych brought up to me. He said that Abilify and it's relative Rexulti, have "pro-cognitive" effects, meaning they help with brain fog, apathy, concentration, motivation, and even energy. Apparently both are used for ADHD, with even the makers of Rexulti trying to get it approved for ADHD. Have any of your experienced this from either of the two? Because I am in need of something that helps with cognition, mainly apathy and low, low motivation and interest.

Bottom line, I am very interested in Abilify and its sister Rexulti. They are very interesting pharmacologically, with them being sort of unique antipsychotics... I would be taking Abilify for depression and as an add on to an antidepressant, by the way. I've always been scared of the word "antipsychotic" but knowing how Seroquel basically annihilated my depression in the past, I can't deny their benefits. Please share your experience, and as always, thanks for helping me out.

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2 hours ago, icygrave said:

   Please share your experience, and as always, thanks for helping me out.

Please keep in mind that this is only my experience with Abilify, and it might work differently for you.

Almost 2 weeks ago, I was taken off Abilify 15mg, by my now former pdoc (I see a new pdoc in a couple of weeks).

I was only on it for 4 months.....I didn't gain any weight from it, and didn't have any bad side effects, but it just didn't seem to be working for me as far as mood and motivation....

My former doc could have tried a slightly higher dose, but he chose not to, and didn't replace it with anything else when he yanked me off it.......He was extremely rude to me when I talked to him about it, which is why I switched docs.....Hopefully my new doc will be replacing Abilify with another AAP that works better, but for now I'm feeling even more depressed since I'm not taking it (Maybe it was doing something--not sure).

Anyway, that's my short experience with Abilify......To sum it all up, I didn't have any weight gain or restlessness, like some people have experienced on  it, but it didn't do much for my depression or motivation, either.

Good luck if you decide to try  Abilify.....It could work great for you.......

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@icygrave

I have taken abilify for over 10 years and I have never had a problem with it. It saved me from a super long state hospital stay. It improved my mood and brought me out of a deep deep deep depression. I had to get to 30 mg to take care of that, however. Ymmv with the dose needed. I don’t know what you are taking it for. I took it along with seroquel for over 10 years for my SZA disorder. But I either got worse or treatment resistant or maybe that combo never really helped that much in the first place because my pdoc says I have treatment resistant psychosis. So now I’m titrating up on clozapine. 

ANYWAY, I gained weight from zyprexa. I gained close to 100 lbs. Like you I gained maybe 10 lbs on seroquel max. But abilfy I did not gain any weight on. And I wasn’t even exercising at that point. I was also able to attend college on abilify, if that says anything. I passed my classes with ease and got good grades. But I crashed hard again and had to drop out permanently. Then I got really sick and never could return. I’m like 2 or 3 classs shy of a degree, so I’m pretty sad about that. 

I’ve never tried rexulti, so I can’t comment on that. But if you have any more specific questions about my experiences with abilify id be more than happy to help! Good luck and I hope it helps you as much as it helps me!

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10 years on Abilify, I have not seen it increase weight. In fact I am at my lowest weight in over 20 years. Abilify did not change my labs WRT glucose, ie fasting and hemoglobin A1C, and I am at my lowest today in over 10 years. It improves negative symptoms like apathy and anhedonia for me while in general functioning as an antidepressant. 

Edited by notloki
add neg symptoms
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Abilify did increase my appetite at first, but it certainly was not the biggest weight gainer I was on at the time. (That was Remeron.) However, this side effect eventually went away for me and became a non-issue.

As to cognition ... When I am depressed, my thoughts are slow, like they are running through molasses. Abilify definitely sped up my thoughts. It was quite noticeable. I don't mean that my thoughts sped up to the point of racing, but that they became normal.

Abilify is a godsend for treating my anhedonia and lack of motivation. No other med could do that. Not even Ritalin. Ritalin gives me energy, but no desire to do anything with it. Abilify gives me the desire to do things and to live life again.

Also, I would like to say that Abilify is the only psych med that has done for me like the commercials said it would. All other meds were no-go or partial, incremental responses. As you can tell, I'm a big fan of Abilify. It is a great med for me.

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