deeschmee Posted December 8, 2018 Share Posted December 8, 2018 Is making me panicky? Heart racing, shaky hands, agitation, trouble staying asleep. Can this be true? I thought that norepinephrine wasn't even released until 150? This stinks Quote Link to comment Share on other sites More sharing options...
BrianOCD Posted December 9, 2018 Share Posted December 9, 2018 (edited) I never had much luck with the mid dosages on Effexor. I found myself irritable and agitated like you're describing. 75 mg and 300 mg were the two that worked for me. Edited December 9, 2018 by BrianOCD 1 Quote Link to comment Share on other sites More sharing options...
deeschmee Posted December 9, 2018 Author Share Posted December 9, 2018 I remember you said that. So the panic can be from venlafexine? Quote Link to comment Share on other sites More sharing options...
BrianOCD Posted December 9, 2018 Share Posted December 9, 2018 1 minute ago, deeschmee said: I remember you said that. So the panic can be from venlafexine? ya possibly, how long you been on 112.5? Quote Link to comment Share on other sites More sharing options...
deeschmee Posted December 9, 2018 Author Share Posted December 9, 2018 3 weeks. When I was at 150, I had the same reaction. I got as high as 225 I think and couldn't handle it Quote Link to comment Share on other sites More sharing options...
BrianOCD Posted December 9, 2018 Share Posted December 9, 2018 I was on 300 mg and that was great because I think it hits all three. But if you don't want to go that high I'd see if your doc will go back to 75mg... 75mg always felt light. What was the reason you went up? Depression or Anxiety? Quote Link to comment Share on other sites More sharing options...
deeschmee Posted December 9, 2018 Author Share Posted December 9, 2018 I thought it would kick my depression a bit. I literally feel like I'm going to die or crawl out of my skin any higher than 75 But at 75 it's just an SSRI right? Maybe I should switch to one Quote Link to comment Share on other sites More sharing options...
HydroCat Posted December 9, 2018 Share Posted December 9, 2018 Have you tried an SSRI before? Usually SSRIs are the first choice before SNRIs. Venlafaxine is, in theory, an SSRI at lower dosages, but it is the same active substance that blocks all three. So in your case it *may* hit the NET although it is "not supposed to". If the NET activity is too high for you, you can try Prozac, which an SSRI with some indirect NE/DA enhancing properties (less than that of SNRIs). Lexapro is the "purest" of SSRIs, hitting, for the most part, only the SERT. This can be an option if any NE enhancement gives you anxiety. 1 Quote Link to comment Share on other sites More sharing options...
deeschmee Posted December 9, 2018 Author Share Posted December 9, 2018 Oh thank you so much!! I was on many different SSRI years ago. I forgot which ones! They made me super tired. When I went on effexor it lifted my depression in a week! I'm going to try another SSRI. Thank you for the recommendations ? Quote Link to comment Share on other sites More sharing options...
Ethansmom Posted December 9, 2018 Share Posted December 9, 2018 I just bumped up from 187.5 to 225 a week ago and am getting heart flutters everyday; I’m irritable and super hungry. The heart flutters freak me out. I think I’m going back down to 187.5. Anyone else have this issue? Quote Link to comment Share on other sites More sharing options...
jt07 Posted December 9, 2018 Share Posted December 9, 2018 8 minutes ago, Ethansmom said: I just bumped up from 187.5 to 225 a week ago and am getting heart flutters everyday; I’m irritable and super hungry. The heart flutters freak me out. I think I’m going back down to 187.5. Anyone else have this issue? Not on Effexor, but I did get it on Wellbutrin. I don't do well with meds that mess with norepinephrine. They make me irritable, anxious, dysphoric, and I feel the effects on my heart too. 1 Quote Link to comment Share on other sites More sharing options...
jt07 Posted December 9, 2018 Share Posted December 9, 2018 18 hours ago, deeschmee said: Is making me panicky? Heart racing, shaky hands, agitation, trouble staying asleep. Can this be true? I thought that norepinephrine wasn't even released until 150? This stinks Action on norepinephrine (NE) doesn't magically kick in at 150 mg. It's always there but less than the serotonin reuptake inhibition, and it is considered to reach a significant amount of NE reuptake inhibition at 150 mg. However, you might be sensitive to it and even the amount of NE reuptake inhibition at 112.5 is too much for you. 1 Quote Link to comment Share on other sites More sharing options...
Ethansmom Posted December 9, 2018 Share Posted December 9, 2018 I take 187.5 and just bumped up. I’m going to reduce my dose tomorrow. I hate feeling pissed off and irritatable for no reason. I hope i don’t feel any withdraw since it’s only been 9 days? Quote Link to comment Share on other sites More sharing options...
notloki Posted December 10, 2018 Share Posted December 10, 2018 23 hours ago, Ethansmom said: I take 187.5 and just bumped up. I’m going to reduce my dose tomorrow. I hate feeling pissed off and irritable for no reason. I hope i don’t feel any withdraw since it’s only been 9 days? If you were stopping the med altogether then you might get discontinuation effects. Quote Link to comment Share on other sites More sharing options...
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