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Hello everyone, I hope everyone's December has been off to a good start. I am back, on the med merry-go-round and also sober from opiates.... Again (16 days as of now).

So I was taking wellbutrin as an add on to my Prozac, and it really didn't help and might have made me worse, losing dramatic amounts of weight, a lot of intrusive thoughts, very depressed (though that's probably just it not doing much for it. And getting off drugs.) so I'm now on the Rexulti starter pack.

I'm here seeking others experiences with abilify and rexulti, since they are both dopamine partial agonists and 5-ht1a partial agonists, amongst other things. I'm very nervous about taking an antipsychotic for depression, though... And just want to know of other's experiences starting these medications. How were the side effects? If you had any, did they eventually go away? Did you gain weight?

I appreciate anyone who shares their experience. I've asked about these meds before, but I'm so nervous about it I just want reassurance. A lot is changing around me. Thank you all so much, and I hope the holidays have been treating you well.

Edited by icygrave
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Greetings icygrave.  Welcome back and congratulations of 16 days sober!  

I've been on varying doses of Abilify since I was 23 years old and I've come to settle on 7mg as a dose that keeps me from being hypomanic or delusional while I still feel I'm myself.  It's a very low dose for schizoaffective but everyone is different. 

The first thing I noticed on Abilify was that alcohol didn't work anymore.   I didn't notice much else aside from lack of mania.  I still feel like a person with thoughts and feelings and even motivation on good days. 

I am morbidly obese but I could have avoided this and I don't blame it on medication alone.  I probably am not the best person to talk about this because I went form having a super-human metabolism, to taking Abilify and eating like I did before.  I gained wait slowly but surely and whenever I set my mind to lose weight I give up because it doesn't magically fall off like it did before the meds.  I was considering a new approach.  Vegan Keto.  It's a relatively ketogenic diet minus animal products.  

At first Abilify made me feel a bit happier than usual but that faded pretty quickly.  I take mine in the morning because to me its slightly activating and definitely not sedating at all.  

Good luck.

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18 minutes ago, TakeAChillPill said:

Greetings icygrave.  Welcome back and congratulations of 16 days sober!  

I've been on varying doses of Abilify since I was 23 years old and I've come to settle on 7mg as a dose that keeps me from being hypomanic or delusional while I still feel I'm myself.  It's a very low dose for schizoaffective but everyone is different. 

The first thing I noticed on Abilify was that alcohol didn't work anymore.   I didn't notice much else aside from lack of mania.  I still feel like a person with thoughts and feelings and even motivation on good days. 

I am morbidly obese but I could have avoided this and I don't blame it on medication alone.  I probably am not the best person to talk about this because I went form having a super-human metabolism, to taking Abilify and eating like I did before.  I gained wait slowly but surely and whenever I set my mind to lose weight I give up because it doesn't magically fall off like it did before the meds.  I was considering a new approach.  Vegan Keto.  It's a relatively ketogenic diet minus animal products.  

At first Abilify made me feel a bit happier than usual but that faded pretty quickly.  I take mine in the morning because to me its slightly activating and definitely not sedating at all.  

Good luck.

Thank you so much for your kind words and helpfulness. I was on seroquel 100mg in 2015, worked very well for my depression but made me a bit dull. Though could've been caused by smoking weed daily... And I gained no weight on it which seroquel is apparently notorious for. Thanks again, I hope you are doing well.

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Rexulti has been wonderful for my depression. However, I'm still feeling out whether or not it's strictly relegated to the lower doses or not. I had to start low and go slow similarly to Abilify (which I could NOT tolerate). Started at 0.5mg for 2 weeks and that was TOO much. We went down to 0.25mg for 6 weeks then increased again to 0.5mg and it was totally different the second time around. I'm now on 1.5mg but dropping down to 1mg tonight because I've been feeling some Winter depression. Rather than take a risk by increasing the Trintellix, we're going to try peeling back things to clear my head a bit and regroup.

All-in-all though, I LOVE Rexulti. This is after Latuda, Saphris, Fanapt, Abilify, Loxitane, Zyprexa. If I had to pick a second choice after the Rexulti, Zyprexa would be it. Both cause weight gain, but with Rexulti it's been WAY less of an issue than with Zyprexa. My blood sugar and lipids are more under control too.

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15 minutes ago, browri said:

Rexulti has been wonderful for my depression. However, I'm still feeling out whether or not it's strictly relegated to the lower doses or not. I had to start low and go slow similarly to Abilify (which I could NOT tolerate). Started at 0.5mg for 2 weeks and that was TOO much. We went down to 0.25mg for 6 weeks then increased again to 0.5mg and it was totally different the second time around. I'm now on 1.5mg but dropping down to 1mg tonight because I've been feeling some Winter depression. Rather than take a risk by increasing the Trintellix, we're going to try peeling back things to clear my head a bit and regroup.

All-in-all though, I LOVE Rexulti. This is after Latuda, Saphris, Fanapt, Abilify, Loxitane, Zyprexa. If I had to pick a second choice after the Rexulti, Zyprexa would be it. Both cause weight gain, but with Rexulti it's been WAY less of an issue than with Zyprexa. My blood sugar and lipids are more under control too.

Rexulti was one of the few that helped my BP depresson...not totally...but enough to give me a good "bump"...I hate abilify so I can't help much there 

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Thanks folks for all your input. I am pleased to update you all with wonderful news; I completely love Rexulti so far. I'm on 1mg and it has been so crazy good. I forgot how big of a difference using an antipsychotic makes, I haven't felt this way since I was on Seroquel 100mg 3 years ago. I hope you all have a wonderful holiday season, and a happy new year.

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6 hours ago, l'appel du vide said:

Thanks folks for all your input. I am pleased to update you all with wonderful news; I completely love Rexulti so far. I'm on 1mg and it has been so crazy good. I forgot how big of a difference using an antipsychotic makes, I haven't felt this way since I was on Seroquel 100mg 3 years ago. I hope you all have a wonderful holiday season, and a happy new year.

That’s amazing news! 

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I've been on Rexulti coming up on 3yrs now, and it's been excellent for depression. However, it did seem to screw with my metabolism at 1mg and above, so while I didn't gain any weight from it, it was really hard to lose any too. Side effects are really minimal, though, and it's been a life saver for me. It kills depression like no other drug I've tried, and it hasn't flatlined or pooped out after almost 3 years. I chose to titrate up on Trintellix and down on Rexulti because I think APs are nasty drugs and I want the lowest possible dose and still be stable, and I needed to lose weight, which was impossible at 2mg of Rexulti. But it will work for monotherapy, and I did it that way for 2 years with great results.

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I second what @dtac says about depression and Rexulti. For some reason this antipsychotic is an amazing antidepressant, I had great results with Rexulti when using it for bipolar disorder. We tried it out to target my manic episodes and symptoms, but it ended up eliminating my depression more so that I went off my antidepressant and Rexulti was enough to keep me feeling happy and without depression. Eventually we made the decision to try other options, Vraylar was one that worked actually really well for mania without having to rely on the manifestation of sedation to relieve manic symptoms. However, now I am on Seroquel XR because no matter which antipsychotic I was on, I would still have to also take Seroquel at night for insomnia. So I suggested to just go with Seroquel XR, add a script for modafanil until the next-day sedation isn't impairing, and see how I respond. It has been actually very well, surprisingly I dont feel sedated all the time.

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On 12/17/2018 at 7:50 PM, mmaryland said:

I second what @dtac says about depression and Rexulti. For some reason this antipsychotic is an amazing antidepressant, I had great results with Rexulti when using it for bipolar disorder. We tried it out to target my manic episodes and symptoms, but it ended up eliminating my depression more so that I went off my antidepressant and Rexulti was enough to keep me feeling happy and without depression. Eventually we made the decision to try other options, Vraylar was one that worked actually really well for mania without having to rely on the manifestation of sedation to relieve manic symptoms. However, now I am on Seroquel XR because no matter which antipsychotic I was on, I would still have to also take Seroquel at night for insomnia. So I suggested to just go with Seroquel XR, add a script for modafanil until the next-day sedation isn't impairing, and see how I respond. It has been actually very well, surprisingly I dont feel sedated all the time.

Following on this, it's been my experience too that Rexulti isn't the GREATEST anti-manic. It's been more helpful for depression and anxiety, and I still depend on Depakote to keep me under control. However, in a pinch when I was having a bit of a mixed episode, we were able to bump the dose from 1mg to 1.5mg and it did settle down after 2-4 days. So it can work for mixed episodes in my experience, but in the long-term on its own I haven't had good anti-manic results from it. Perhaps though that positive effect it has on anxiety does lend to some anti-manic effect transitively, but I'm not convinced I could go without Depakote entirely in favor of Rexulti.

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