Next-day response to Trintellix

[sming]

Hello CrazyBoards,

I started 5mg Trintellix a week ago and in a nutshell, felt 40-50% better the very next day. Before I get deafened with shouts of "PLACEBO!", think again since I'm treatment-resistant (20+ years) and never expect meds to work - because they nearly always don't. FTR I've tried tens of med combos, treatments, ECT, dTMS unsuccessfully. They either make me worse, have no effect or help somewhat and then poop-out within 2-4 weeks.

Furthermore my mood started dipping significantly 3 days ago so I upped the dose to 7.5mg last night, again not expecting anything and lo and behold, I felt significantly better - like "naturally" or "simply" better today. 

Has anyone heard of, or experienced such a rapid improvement?

Pete

[looking for answers]

no, im thinking placebo, just because your TR, doesnt mean you dont have hope

[Beth45]

Hi Pete,

I have a the same experience ONCE, when I started cymbalta the next day I felt like I had more energy and felt less depressed.   It continued to get better each day I was on cymbalta but unfortunately it was short lived and pooped out after a few months.  So I do believe that can happen and not be a "placebo" effect.  I hope it continues to work for you.  Unfortunately trintellix did not work for me. As like you, I am med resistant to the majority of medications I have tried. 

[sming]

1 hour ago, looking for answers said:

no, im thinking placebo, just because your TR, doesnt mean you dont have hope

I appreciate I cannot be objective in this discussion but I respectfully disagree.
A) I'm severely depressed - my brain just doesn't "do" hope. Hasn't done so for many, many years.
B) 19/20 meds make me worse or have no effect so it's actually logical and realistic for me to have little to no hope.
C) I felt significantly different. Not just more optimistic or hopeful or less down - significantly different both cognitively and emotionally.

[argh]

I've only heard of such rapid and positive change with taking ADs, occur in people who are bipolar. But bipolar meds didn't work for you right?

[looking for answers]

45 minutes ago, argh said:

I've only heard of such rapid and positive change with taking ADs, occur in people who are bipolar. But bipolar meds didn't work for you right?

even in bp that change is not next  day

[BrianOCD]

Placebo or not, if he's feeling better that's all that really matters...

[looking for answers]

5 hours ago, BrianOCD said:

Placebo or not, if he's feeling better that's all that really matters...

agree, i wouldnt worry about why. He just asked

[notloki]

That rapid a response I've only seen in bipolar folk who take certain AD's or someone who did not realize they are bipolar and took certain AD's. Time will tell.

[Iceberg]

As long as your on top of monitoring for "too much" improvement, better is better 

[sming]

On 1/12/2019 at 10:24 PM, argh said:

I've only heard of such rapid and positive change with taking ADs, occur in people who are bipolar. But bipolar meds didn't work for you right?

Yeah that's correct, unfortunately.

On 1/15/2019 at 1:51 AM, BrianOCD said:

Placebo or not, if he's feeling better that's all that really matters...

Sadly @BrianOCD, it didn't last and I crashed on day 4 - hence no replies from me... until today since it's the first day in a week where I've felt human again. Let's hope it lasts for longer than 3 days this time (I'm not holding my breath).

[sming]

20 hours ago, notloki said:

That rapid a response I've only seen in bipolar folk who take certain AD's or someone who did not realize they are bipolar and took certain AD's. Time will tell.

As @argh mentioned I'm not BPx unfortunately. I'm a medical conundrum wrapped in an enigma, veiled by mysteriousness. AKA "fucked".

[Beautiful50]

On 1/15/2019 at 1:51 AM, BrianOCD said:

Placebo or not, if he's feeling better that's all that really matters...

Yes as long as one is out of that depressive funk hey I’m happy for anyone who feels better Amen