I'm a 20+ year sufferer of extremely TRD and am trying LSD (1P-LSD, more specifically) microdosing to help lift my mood and combat anhedonia. I'd love to know if anyone else has tried this. Specifically:
what was your regimen? e.g. every 3 days?, dosage, substance, method did any initial beneficial effects increase over time? if so, over what kind of period? did you develop a tolerance? did it help with your anhedonia? did you try more than a microdose e.g. 1/4, 1/2 or even a whole tab? If so, how was that therapeutically? FTR, I'm taking 10ug (1/10th of a tab) every 3 days using the volumetric method. I felt notably more energetic and less severely depressed within an hour of dosing. This persisted for ~ 14 hours. I couldn't sleep. Now, the next day, I feel kind of back to normal (i.e. feel very depressed and anhedonic), which is very demoralising.
I've been relatively stable with a few jags here and there for almost 2 years, and suddenly I'm experiencing some depression that has me in tears at times, as well as anxiety that results in panic attacks so bad that I feel like I can't breathe. I'm very emotionally labile, reactive to any trigger, sending me to seclusion with my depression.
The only thing that has changed is that I swapped Dexedrine to Bontril-PDM for my weight management (and with Bontril-PDM, off-label ADHD management, idiopathic hypersomnia management, and treatment of refractory bipolar depression). I'm thinking this may be the trigger, but I needed to take a break from Dexedrine because my receptors were too desensitized to it and I was starting to gain weight, sleep all day, become very inattentive (like almost having wrecks kind of inattentive), and feel a little depressed. So I may have identified my trigger, but I need to take a good break from Dexedrine so when I resume it, it will work as it did when I first started it.
My question is how does one prevent depression (neurochemical, not cognitive)? Is there something that can be temporarily added to my cocktail? I see my pdoc Friday. I have tried lithium and it causes seizures. Depakote makes me a zombie. Lamictal causes horrendous acne. I'd rather not add a second antipsychotic. Increasing the antidepressants seem to do nothing.
Should I just get back on Dexedrine ASAP? Or continue to give it a break and try other alternatives? I thought about trying Ritalin again, but a much higher dose than I've tried before, like 40-60 mg in Metadate CD form (the only form I felt anything from with methylphenidate). Concerta and regular Ritalin are useless, and I've heard bad things about Ritalin LA.
Any responses or insight would be much appreciated! Thanks in advance!
Just to preface, I don't take Ritalin for ADHD...it's more for Depression, motivation, procrastination, mental stamina purposes.
Has anyone found that you get TOO focused on it? Maybe because I don't actually have ADHD, but I start working on 1 thing and become OBSESSIVELY focused on it (like it brings out the uber perfectionist in me). I forget to eat, I don't take breaks from my desk, and then my brain just shuts off from exhaustion. At the end, I've accomplished only 1-2 tasks.
I have great difficulty switching tasks or getting all "priority" things done, because I get so stuck on working for HOURS on the same little thing!
Basically, my processing speed is much slower, I can't adjust to "fast paced" situations, because I mull on things, make revisions over & over & over etc. On the other hand, if i go without taking it, I lay around, procrastinate, lack all motivation, and I'm unable to start anything at all. Not sure how to solve this? Do other stimulants work in the same way?
Hi everyone. I’ve been bouncing from one trial of medication to another for the past 4 1/2 years with adverse reactions. Nothing has helped. I just saw a new psychiatrist on Monday. An older gentleman who actually seemed to listen. He was also a longtime professor our local university.
My symptoms are treatment resistant insomnia, chronic, severe anxiety, chronic derealization, ocd (pure o) racing, intrusive thoughts (often presenting as songs looping in my head, but a switch can also go off in my head where I obsessively think about something to the point of it driving me crazy) brain fog, depression. My body and brown simply will not turn off. I’m stuck in constant fight/flight. I believe the lack of sleep is the catalyst for most of this (all of this started after sudden onset of insomnia) Maybe it wouldn’t go away with sleep, but I know it would get better. My main goal is sleep, but seems unattainable after 4 1/2 years.
I have tried every medication under the sun (well, mostly)
The doctor decided to prescribe provigil (modafinil) which seems counterintuitive to me. He was clear that it could go either way. Possible that it could calm me down, possible that it could let me up and make my symptoms worse.
Luckily for me, since I am highly sensitive to medication, he is quite conservative and said to only start with roughly 1/16 of a pill to see how I do.
Wondering what your thoughts are on this given my symptoms? Seems counterintuitive...but maybe it will help. So confused.